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Proteins/UNIPROT:P48664
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable)..
Function from UniProtKB (P48664), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
108 statements
108 statements · 7 reference databases · Subject: SLC1A6 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
8 reactions
L-glutamate(1-)+proton+potassium atom+3sodium(1+)L-glutamate(1-)+proton+potassium atom+3sodium(1+)
Transported by SLC1A3 or SLC1A6 or SLC1A1 or SLC1A2 or SLC1A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04932CC BY 4.0Reference data
3 names
Resolves to: SLC1A6
L-aspartate+sodium(1+)L-aspartate+sodium(1+)
Transported by SLC1A3 or SLC1A6 or SLC1A1 or SLC1A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05328CC BY 4.0Reference data
L-glutamate(1-)+sodium(1+)L-glutamate(1-)+sodium(1+)
Transported by SLC1A3 or SLC1A6 or SLC1A1 or SLC1A2 or SLC1A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05330CC BY 4.0Reference data
L-aspartate+proton+potassium atom+3sodium(1+)L-aspartate+proton+potassium atom+3sodium(1+)
Transported by SLC1A3 or SLC1A6 or SLC1A1 or SLC1A2 or SLC1A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05447CC BY 4.0Reference data
D-aspartic acid+proton+potassium atom+3sodium(1+)D-aspartic acid+proton+potassium atom+3sodium(1+)
Transported by SLC1A3 or SLC1A6 or SLC1A1 or SLC1A2 or SLC1A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR07639CC BY 4.0Reference data
K(+)+L-glutamate(1-)+3sodium(1+)+hydronK(+)+L-glutamate(1-)+3sodium(1+)+hydron
Transported by SLC1A7 or SLC1A3 or SLC1A2 or SLC1A1 or SLC1A6
Reaction pageDirection not assertedBalanced
Rhea RHEA:70699CC BY 4.0Reference data
K(+)+L-aspartate+3sodium(1+)+hydronK(+)+L-aspartate+3sodium(1+)+hydron
Transported by SLC1A7 or SLC1A3 or SLC1A2 or SLC1A1 or SLC1A6
Reaction pageDirection not assertedBalanced
Rhea RHEA:70851CC BY 4.0Reference data
D-aspartate+K(+)+3sodium(1+)+hydronD-aspartate+K(+)+3sodium(1+)+hydron
Transported by SLC1A7 or SLC1A3 or SLC1A2 or SLC1A1 or SLC1A6
Reaction pageDirection not assertedBalanced
Rhea RHEA:71379CC BY 4.0Reference data