Proteins/UNIPROT:Q86XP0

PLA2G4D

ProteinUNIPROT:Q86XP0Cytosolic phospholipase A2 delta

Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has a preference for linoleic acid at the sn-2 position..

Function from UniProtKB (Q86XP0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

30 statements

30 statements · 6 reference databases · Subject: PLA2G4D · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

Order

ASIC5 covaries with PLA2G4DProteinHetionet hetionet:covaries:283748-51802Inferred only
GIMAP2 covaries with PLA2G4DProteinHetionet hetionet:covaries:26157-283748Inferred only
APP interacts with PLA2G4DProteinHetionet hetionet:interacts:283748-351Inferred only
PLA2G4D participates in Acyl chain remodelling of PCPathwayReactome R-HSA-1482788Inferred only
PLA2G4D participates in Acyl chain remodelling of PEPathwayReactome R-HSA-1482839Inferred only
PLA2G4D participates in Acyl chain remodelling of PGPathwayReactome R-HSA-1482925Inferred only
PLA2G4D participates in Acyl chain remodelling of PIPathwayReactome R-HSA-1482922Inferred only
PLA2G4D participates in Acyl chain remodelling of PSPathwayReactome R-HSA-1482801Inferred only
PLA2G4D participates in Glycerophospholipid biosynthesisPathwayReactome R-HSA-1483206Inferred only
PLA2G4D participates in Hydrolysis of LPCPathwayReactome R-HSA-1483115Inferred only
PLA2G4D participates in Lipid metabolism in senescent cellsPathwayWikiPathways WP5149Inferred only
PLA2G4D participates in MAPK signalingPathwayWikiPathways WP382Inferred only

Show the remaining 18

PLA2G4D participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
PLA2G4D participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
PLA2G4D participates in Phospholipid metabolismPathwayReactome R-HSA-1483257Inferred only
PLA2G4D participates in Ras signalingPathwayWikiPathways WP4223Inferred only
PLA2G4D participates in Synthesis of PAPathwayReactome R-HSA-1483166Inferred only
PLA2G4D requires the cofactor Ca(2+)CompoundUniProt Q86XP0Inferred only
1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine is a substrate of PLA2G4DCompoundHuman-GEM MAR07603Inferred only
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine is a substrate of PLA2G4DCompoundRhea RHEA:40427Inferred only
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine is a substrate of PLA2G4DCompoundRhea RHEA:40431Inferred only
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine is a substrate of PLA2G4DCompoundRhea RHEA:38779Inferred only
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine is a substrate of PLA2G4DCompoundRhea RHEA:40811Inferred only
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine is a substrate of PLA2G4DCompoundRhea RHEA:40815Inferred only
1,2-diacyl-sn-glycero-3-phosphocholine(1+) is a substrate of PLA2G4DCompoundHuman-GEM MAR05254Inferred only
1,2-diacyl-sn-glycero-3-phosphocholine(1+) is a substrate of PLA2G4DCompoundHuman-GEM MAR00463Inferred only
1,2-diacyl-sn-glycero-3-phosphocholine(1+) is a substrate of PLA2G4DCompoundHuman-GEM MAR00630Inferred only
a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine is a substrate of PLA2G4DCompoundHuman-GEM MAR07615Inferred only
a 1,2-diacyl-sn-glycero-3-phosphocholine is a substrate of PLA2G4DCompoundRhea RHEA:15801Inferred only
phosphatidylethanolamine is a substrate of PLA2G4DCompoundHuman-GEM MAR00643Inferred only

Reactions

12 reactions

water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+proton+fatty acid
Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and

Other names

2 names

Resolves to: PLA2G4D

Also called: cPLA2-deltaPhospholipase A2 group IVD

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6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4endoplasmic reticulum

Human-GEM MAR00463CC BY 4.0Reference data

water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+proton+fatty acid

Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol

Human-GEM MAR00630CC BY 4.0Reference data

water+phosphatidylethanolamineMAM00511c+proton+fatty acid

Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol

Human-GEM MAR00643CC BY 4.0Reference data

water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)1-O-acyl-sn-glycero-3-phosphocholine(1+)+proton+fatty acid

Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4lysosome

Human-GEM MAR05254CC BY 4.0Reference data

water+1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine1-(alk-1-enyl)-sn-glycero-3-phosphoethanolamine+proton+fatty acid

Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol

Human-GEM MAR07603CC BY 4.0Reference data

a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine+waterMAM00549c+proton+fatty acid

Catalysed by PLA2G10 or PLA2G3 or PLA2G4C or PLA2G4A or PLA2G2D or PLA2G12A or PLA2G5 or PLA2G2F or PLA2G4D or PLB1 or PLA2G4F or PLA2G1B and 6 more alternatives

Reaction pageLeft to rightBalance undeterminableEC 3.1.1.4cytosol

Human-GEM MAR07615CC BY 4.0Reference data

a 1,2-diacyl-sn-glycero-3-phosphocholine+watera 1-acyl-sn-glycero-3-phosphocholine+a fatty acid+hydron

Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G4B or PLA2G2A or PRDX6 or PLA2G5 or PNPLA4 or PLA2G4A or PLAAT3 or PLA2G4E or PLA2G4F and 18 more alternatives

Reaction pageLeft to rightBalance undeterminable

Rhea RHEA:15801CC BY 4.0Reference data

1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphocholine+(9Z)-octadecenoate+hydron

Catalysed by PLA2G10 or PLA2G6 or PLA2G1B or PLA2G2A or PLA2G5 or PLAAT3 or PLB1 or PLA2G4D or PLA2G15 or PLA2G2F or PNPLA8 or PLAAT2 and 4 more alternatives

Reaction pageLeft to rightBalanced

Rhea RHEA:38779CC BY 4.0Reference data

1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine+water1-hexadecanoyl-sn-glycero-3-phosphocholine+(5Z,8Z,11Z,14Z)-eicosatetraenoate+hydron

Catalysed by PLA2G6 or PLA2G1B or LCAT or PLA2G4B or PLA2G5 or PLA2G4A or PLAAT3 or PLA2G4E or PLA2G4F or PLA2G4D or PNPLA8 or PLA2G3 and 1 more alternative

Reaction pageLeft to rightBalanced

Rhea RHEA:40427CC BY 4.0Reference data

1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine+water1-hexadecanoyl-sn-glycero-3-phosphoethanolamine+(5Z,8Z,11Z,14Z)-eicosatetraenoate+hydron

Catalysed by PLA2G6 or PLA2G4B or PLA2G2A or PLA2G5 or PLAAT3 or PLA2G4F or PLA2G4D or PLA2G2F or PLAAT1 or PNPLA8 or PLAAT2 or PLA2G3 and 1 more alternative

Reaction pageLeft to rightBalanced

Rhea RHEA:40431CC BY 4.0Reference data

1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine+water(9Z,12Z)-octadecadienoate+1-hexadecanoyl-sn-glycero-3-phosphocholine+hydron

Catalysed by PLA2G6 or LCAT or PLA2G2A or PLA2G4A or PLAAT3 or PLA2G4F or PLB1 or PLA2G4D or PNPLA8 or PLA2G3 or PLA2G2E or PLA2G2D and 1 more alternative

Reaction pageLeft to rightBalanced

Rhea RHEA:40811CC BY 4.0Reference data

1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine+water1-hexadecanoyl-sn-glycero-3-phosphoethanolamine+(9Z,12Z)-octadecadienoate+hydron

Catalysed by PLA2G10 or PLA2G1B or PLA2G4B or PLA2G2A or PLA2G5 or PLAAT3 or PLA2G4F or PLA2G4D or PLA2G2F or PLAAT2 or PLA2G3 or PLA2G2E and 2 more alternatives

Reaction pageLeft to rightBalanced

Rhea RHEA:40815CC BY 4.0Reference data