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Proteins/UNIPROT:Q9H222
ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Required for normal sterol homeostasis. The heterodimer with ABCG8 has ATPase activity..
Function from UniProtKB (Q9H222), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
62 statements
62 statements · 8 reference databases · Subject: ABCG5 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
4 reactions
ATP+CHEBI:1307929+waterADP+CHEBI:1307929+proton+phosphate(3-)
Transported by ABCG8 & ABCG5 or ABCA1 or ABCG1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01911CC BY 4.0Reference data
1 name
Resolves to: ABCG5
Reaction pageLeft to rightBalancedendoplasmic reticulum, extracellular space
Human-GEM MAR02221CC BY 4.0Reference data
cholesterol+ATP(4-)+watercholesterol+ADP(3-)+hydrogenphosphate+hydron
Transported by ABCA8 or ABCA1 or ABCG1 or ABCA13 or ABCA5 or ABCA3 or ABCG4 or ABCG8 or ABCG5
Reaction pageLeft to rightBalanced
Rhea RHEA:39051CC BY 4.0Reference data
CHEBI:27693+ATP(4-)+waterCHEBI:27693+ADP(3-)+hydrogenphosphate+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:39103CC BY 4.0Reference data