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Proteins/UNIPROT:P43250
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G protein-coupled receptor: LRP6 during Wnt signaling (in vitro)..
Function from UniProtKB (P43250), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
73 statements
73 statements · 4 reference databases · Subject: GRK6 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
1 reaction
[G protein-coupled receptor]+ATP(4-)[G protein-coupled receptor]-phosphate+ADP(3-)+hydron
Catalysed by GRK2 or GRK4 or GRK5 or GRK3 or GRK6
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12008CC BY 4.0Reference data
2 names
Resolves to: GRK6