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Proteins/UNIPROT:P15529
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity..
(Microbial infection) A number of viral and bacterial pathogens seem to bind MCP in order to exploit its immune regulation property and directly induce an immunosuppressive phenotype in T-cells.
(Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3..
(Microbial infection) Acts as a receptor for cultured Measles virus..
(Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6..
(Microbial infection) May act as a receptor for pathogenic bacteria Neisseria and Streptococcus pyogenes.
(Microbial infection) Plays a minor role in fiber protein-mediated human adenovirus 55 infection; via its interaction with fiber protein. Plays a minor role in fiber protein-mediated human adenovirus 14a infection..
Function from UniProtKB (P15529), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
44 statements
44 statements · 4 reference databases · Subject: CD46 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
5 names
Resolves to: CD46