Loading the page.
Proteins/UNIPROT:Q92800
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation..
Function from UniProtKB (Q92800), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
85 statements
85 statements · 6 reference databases · Subject: EZH1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Reactome, WikiPathways
5 reactions
3 names
Resolves to: EZH1
Reaction pageReversibleBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR04241CC BY 4.0Reference data
MAM00204n+S-adenosyl-L-methionineproton+MAM02129n+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or EZH2 or EZH1 or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR08025CC BY 4.0Reference data
MAM02129n+S-adenosyl-L-methionineMAM00212n+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or EZH2 or EZH1 or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR08026CC BY 4.0Reference data
MAM00212n+S-adenosyl-L-methionineMAM00211n+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or EZH2 or EZH1 or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR08027CC BY 4.0Reference data
L-lysyl(27)-[histone H3]+3S-adenosyl-L-methionineN(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3]+3S-adenosyl-L-homocysteine+3hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:60292CC BY 4.0Reference data