Proteins/UNIPROT:O43559

FRS3

ProteinUNIPROT:O43559

Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2..

Function from UniProtKB (O43559), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

47 statements

47 statements · 3 reference databases · Subject: FRS3 · Sources: Hetionet, Reactome, WikiPathways

Order

FRS3 covaries with CLEC12BProteinHetionet hetionet:covaries:10817-387837Inferred only
FRS3 covaries with FANCEProteinHetionet hetionet:covaries:10817-2178Inferred only
FRS3 covaries with KCNG3ProteinHetionet hetionet:covaries:10817-170850Inferred only
FRS3 covaries with KRTAP10-4ProteinHetionet hetionet:covaries:10817-386672Inferred only
FRS3 covaries with PHC1ProteinHetionet hetionet:covaries:10817-1911Inferred only
FRS3 covaries with PTPN9ProteinHetionet hetionet:covaries:10817-5780Inferred only
FRS3 covaries with SEC22CProteinHetionet hetionet:covaries:10817-9117Inferred only
FGFR1 interacts with FRS3ProteinHetionet hetionet:interacts:10817-2260Inferred only
KARS1 interacts with FRS3ProteinHetionet hetionet:interacts:10817-3735Inferred only
PRKCI interacts with FRS3ProteinHetionet hetionet:interacts:10817-5584Inferred only
FRS3 participates in Activated NTRK2 signals through FRS2 and FRS3PathwayReactome R-HSA-9028731Inferred only
FRS3 participates in Brain derived neurotrophic factor BDNF signalingPathwayWikiPathways WP2380Inferred only

Show the remaining 35

FRS3 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
FRS3 participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
FRS3 participates in Downstream signaling of activated FGFR1PathwayReactome R-HSA-5654687Inferred only
FRS3 participates in Downstream signaling of activated FGFR2PathwayReactome R-HSA-5654696Inferred only
FRS3 participates in Downstream signaling of activated FGFR3PathwayReactome R-HSA-5654708Inferred only
FRS3 participates in Downstream signaling of activated FGFR4PathwayReactome R-HSA-5654716Inferred only
FRS3 participates in FRS-mediated FGFR1 signalingPathwayReactome R-HSA-5654693Inferred only
FRS3 participates in FRS-mediated FGFR2 signalingPathwayReactome R-HSA-5654700Inferred only
FRS3 participates in FRS-mediated FGFR3 signalingPathwayReactome R-HSA-5654706Inferred only
FRS3 participates in FRS-mediated FGFR4 signalingPathwayReactome R-HSA-5654712Inferred only
FRS3 participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
FRS3 participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
FRS3 participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
FRS3 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
FRS3 participates in RND1 GTPase cyclePathwayReactome R-HSA-9696273Inferred only
FRS3 participates in RND2 GTPase cyclePathwayReactome R-HSA-9696270Inferred only
FRS3 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
FRS3 participates in Signaling by ALK fusions and activated point mutantsPathwayReactome R-HSA-9725370Inferred only
FRS3 participates in Signaling by ALK in cancerPathwayReactome R-HSA-9700206Inferred only
FRS3 participates in Signaling by FGFRPathwayReactome R-HSA-190236Inferred only
FRS3 participates in Signaling by FGFR1PathwayReactome R-HSA-5654736Inferred only
FRS3 participates in Signaling by FGFR2PathwayReactome R-HSA-5654738Inferred only
FRS3 participates in Signaling by FGFR3PathwayReactome R-HSA-5654741Inferred only
FRS3 participates in Signaling by FGFR4PathwayReactome R-HSA-5654743Inferred only
FRS3 participates in Signaling by NTRK2 (TRKB)PathwayReactome R-HSA-9006115Inferred only
FRS3 participates in Signaling by NTRKsPathwayReactome R-HSA-166520Inferred only
FRS3 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
FRS3 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
FRS3 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
FRS3 increases the expression of ABCC5ProteinHetionet hetionet:regulates:10817-10057Inferred only
FRS3 decreases the expression of CCDC86ProteinHetionet hetionet:regulates:10817-79080Inferred only
FRS3 increases the expression of EPHA3ProteinHetionet hetionet:regulates:10817-2042Inferred only
FRS3 decreases the expression of HAT1ProteinHetionet hetionet:regulates:10817-8520Inferred only
FRS3 decreases the expression of IARS2ProteinHetionet hetionet:regulates:10817-55699Inferred only
FRS3 decreases the expression of SLC25A46ProteinHetionet hetionet:regulates:10817-91137Inferred only

Other names

4 names

Resolves to: FRS3

Also called: FGFR substrate 3FGFR-signaling adaptor SNT2SNT-2Suc1-associated neurotrophic factor target 2

← Every protein Find it in the graph →