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Proteins/UNIPROT:Q9NPI6
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. Essential for embryonic development..
Function from UniProtKB (Q9NPI6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
101 statements
101 statements · 3 reference databases · Subject: DCP1A · Sources: Hetionet, Reactome, WikiPathways
1 reaction
a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA+waterCHEBI:63714+a 5'-end phospho-ribonucleoside in mRNA+2hydron
Catalysed by NUDT3 or NUDT17 or DCP2 or DCP1B or NUDT16 or DCP1A
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:67484CC BY 4.0Reference data
3 names
Resolves to: DCP1A