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Proteins/UNIPROT:Q96J66
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Plays a role in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides, including cAMP and cGMP. Mediates the ATP-dependent efflux of a range of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates, such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Plays a role in the transport of earwax components. Participates in the secretion of odorants and their precursors from the apocrine sweat glands, including the secretion of glutamine conjugates, as well as the Cys-Gly-(S) conjugates of 3-methyl-3-sulfanyl-hexanol. Involved in the cellular extrusion of nucleotide analogs, hence conferring resistance to various drugs, including clinically relevant drugs such as 5-fluorouracil (5-FU) and methotrexate..
Function from UniProtKB (Q96J66), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
32 statements
32 statements · 4 reference databases · Subject: ABCC11 · Sources: Hetionet, Human-GEM, Reactome, Rhea
29 reactions
ATP+glycocholate+waterADP+glycocholate+proton+phosphate(3-)
Transported by ABCB11 or ABCC3 or ABCC4 or SLC51A or SLC51B or ABCC11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01868CC BY 4.0Reference data
2 names
Resolves to: ABCC11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR01870CC BY 4.0Reference data
dehydroepiandrosterone 3-sulfatedehydroepiandrosterone 3-sulfate
Transported by ABCC11 or SLCO2B1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06249CC BY 4.0Reference data
ATP+3',5'-cyclic AMP+waterADP+3',5'-cyclic AMP+proton+phosphate(3-)
Transported by ABCC5 or ABCC11 or ABCC4
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07691CC BY 4.0Reference data
ATP+3',5'-cyclic GMP+waterADP+3',5'-cyclic GMP+proton+phosphate(3-)
Transported by ABCC5 or ABCC11 or ABCC4
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR07692CC BY 4.0Reference data
ATP+dehydroepiandrosterone 3-sulfate+waterADP+dehydroepiandrosterone 3-sulfate+proton+phosphate(3-)
Transported by ABCC11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR09877CC BY 4.0Reference data
ATP+estrone 3-sulfate+waterADP+estrone 3-sulfate+proton+phosphate(3-)
Transported by ABCC11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR09880CC BY 4.0Reference data
ATP+water+lithocholic acidADP+proton+lithocholic acid+phosphate(3-)
Transported by ABCB11 or ABCC3 or ABCC11
Reaction pageLeft to rightBalancedEC 6.3.2.11cytosol, extracellular space
Human-GEM MAR10010CC BY 4.0Reference data
deoxycholate+ATP+waterdeoxycholate+ADP+proton+phosphate(3-)
Transported by ABCB11 or ABCC3 or ABCC11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR10014CC BY 4.0Reference data
ATP+water+taurodeoxycholateADP+proton+phosphate(3-)+taurodeoxycholate
Transported by ABCB11 or ABCC3 or ABCC11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR10020CC BY 4.0Reference data
ATP+water+tauroursodeoxycholateADP+proton+phosphate(3-)+tauroursodeoxycholate
Transported by ABCB11 or ABCC3 or ABCC11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR10451CC BY 4.0Reference data
ATP+glycoursodeoxycholate+waterADP+glycoursodeoxycholate+proton+phosphate(3-)
Transported by ABCB11 or ABCC3 or ABCC11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR10452CC BY 4.0Reference data