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Proteins/UNIPROT:P21439
[Isoform 1]: Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts. Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to further enrichment of SM and cholesterol in raft membranes in hepatocytes. Required for proper phospholipid bile formation (By similarity). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner. Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane. In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts. Does not confer multidrug resistance (By similarity)..
Function from UniProtKB (P21439), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
53 statements
53 statements · 8 reference databases · Subject: ABCB4 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
36 reactions
ATP+MAM01395c+waterADP+MAM01395e+proton+phosphate(3-)
Transported by ABCB4
Reaction pageLeft to rightBalance undeterminablecytosol, extracellular space
Human-GEM MAR00470CC BY 4.0Reference data
ATP+water+1,2-diacyl-sn-glycero-3-phosphocholine(1+)ADP+proton
5 names
Resolves to: ABCB4
Reaction pageLeft to rightBalance undeterminablecytosol, extracellular space
Human-GEM MAR00476CC BY 4.0Reference data
ATP+water+phosphatidylethanolamineADP+proton+phosphatidylethanolamine+phosphate(3-)
Transported by ABCB4 or ATP8A1 or ATP10A
Reaction pageLeft to rightBalance undeterminableEC 7.6.2.1cytosol, extracellular space
Human-GEM MAR01594CC BY 4.0Reference data
MAM00516c+ATP+waterMAM00516e+ADP+proton+phosphate(3-)
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalance undeterminableEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11572CC BY 4.0Reference data
a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine+ATP+watera 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine+ADP+proton+phosphate(3-)
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalance undeterminableEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11582CC BY 4.0Reference data
ATP+water+MAM03827cADP+proton+phosphate(3-)+MAM03827e
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11587CC BY 4.0Reference data
ATP+water+MAM03805cADP+proton+phosphate(3-)+MAM03805e
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11588CC BY 4.0Reference data
ATP+water+MAM03806cADP+proton+phosphate(3-)+MAM03806e
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11589CC BY 4.0Reference data
ATP+water+MAM03808cADP+proton+phosphate(3-)+MAM03808e
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11590CC BY 4.0Reference data
ATP+water+1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineADP+proton+phosphate(3-)+1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11591CC BY 4.0Reference data
ATP+water+MAM03810cADP+proton+phosphate(3-)+MAM03810e
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11592CC BY 4.0Reference data
ATP+water+MAM03811cADP+proton+phosphate(3-)+MAM03811e
Transported by ABCB4 or ATP8B1 or ATP8B2 or ABCA1 or ATP10A
Reaction pageLeft to rightBalancedEC 7.6.2.2, 7.6.2.1cytosol, extracellular space
Human-GEM MAR11593CC BY 4.0Reference data