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Proteins/UNIPROT:Q05932
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates..
Function from UniProtKB (Q05932), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
97 statements
97 statements · 4 reference databases · Subject: FPGS · Sources: Hetionet, Human-GEM, UniProt, WikiPathways
20 reactions
6ATP+6L-glutamate(1-)+5,6,7,8-tetrahydrofolic acid6ADP+6proton+6phosphate(3-)+MAM02981c
Catalysed by FPGS
Reaction pageLeft to rightBalancedEC 6.3.2.17cytosol
Human-GEM MAR05392CC BY 4.0Reference data
3 names
Resolves to: FPGS
Catalysed by FPGS
Reaction pageLeft to rightBalancedEC 6.3.2.17cytosol
Human-GEM MAR07908CC BY 4.0Reference data
10-formyltetrahydrofolic acid+4ATP+4L-glutamate(1-)MAM00267m+4ADP+4proton+4phosphate(3-)
Catalysed by FPGS
Reaction pageLeft to rightBalancedEC 6.3.2.17mitochondrial matrix
Human-GEM MAR07909CC BY 4.0Reference data
MAM00267c+ATP+L-glutamate(1-)MAM00268c+ADP+proton+phosphate(3-)
Catalysed by FPGS
Reaction pageLeft to rightBalancedEC 6.3.2.17cytosol
Human-GEM MAR07910CC BY 4.0Reference data
MAM00267m+ATP+L-glutamate(1-)MAM00268m+ADP+proton+phosphate(3-)
Catalysed by FPGS
Reaction pageLeft to rightBalancedEC 6.3.2.17mitochondrial matrix
Human-GEM MAR07911CC BY 4.0Reference data
MAM00268c+ATP+L-glutamate(1-)MAM00269c+ADP+proton+phosphate(3-)
Catalysed by FPGS
Reaction pageLeft to rightBalancedEC 6.3.2.17cytosol
Human-GEM MAR07912CC BY 4.0Reference data
MAM00268m+ATP+L-glutamate(1-)MAM00269m+ADP+proton+phosphate(3-)
Catalysed by FPGS
Reaction pageLeft to rightBalancedEC 6.3.2.17mitochondrial matrix
Human-GEM MAR07913CC BY 4.0Reference data
4ATP+7,8-dihydrofolate+4L-glutamate(1-)4ADP+4proton+MAM02691c+4phosphate(3-)
Catalysed by FPGS
Reaction pageLeft to rightBalancedEC 6.3.2.17cytosol
Human-GEM MAR08105CC BY 4.0Reference data
ATP+L-glutamate(1-)+MAM02691cADP+proton+MAM02118c+phosphate(3-)
Catalysed by FPGS
Reaction pageLeft to rightBalancedEC 6.3.2.17cytosol
Human-GEM MAR08106CC BY 4.0Reference data
ATP+L-glutamate(1-)+MAM02118cADP+proton+MAM02104c+phosphate(3-)
Catalysed by FPGS
Reaction pageLeft to rightBalancedEC 6.3.2.17cytosol
Human-GEM MAR08107CC BY 4.0Reference data
4ATP+4L-glutamate(1-)+5,6,7,8-tetrahydrofolic acid4ADP+4proton+MAM02692c+4phosphate(3-)
Catalysed by FPGS
Reaction pageLeft to rightBalancedEC 6.3.2.17cytosol
Human-GEM MAR08108CC BY 4.0Reference data
ATP+L-glutamate(1-)+MAM02692cADP+proton+MAM02119c+phosphate(3-)
Catalysed by FPGS
Reaction pageLeft to rightBalancedEC 6.3.2.17cytosol
Human-GEM MAR08109CC BY 4.0Reference data