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Reach

Se-methylselenocysteine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

254 compounds within 3 steps: 4 in 1, 52 in 2, 198 in 3

Does it reach a compound?

Two steps

5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideReach from here →
1. Methionine Synthase
2. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
Catalysed by ATICnucleus, cytosol
(3S)-citramalyl-CoAReach from here →
1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
2. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA
Catalysed by SCLY, CLYBLcytosol
5-amino-2-oxopentanoateReach from here →
1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
Catalysed by SCLY, AGXT2cytosol
(4R)-4-hydroxy-2-oxoglutarateReach from here →
1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
2. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Catalysed by SCLY, HOGA1cytosol
(4S)-4-hydroxy-2-oxoglutarateReach from here →
1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
2. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Catalysed by SCLY, HOGA1cytosol
2-(1-hydroxyethyl)thiamine diphosphateReach from here →
1. Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
2. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Catalysed by SCLY, PDHA1, PDHB, PDHA2cytosol, mitochondrial matrix

Three steps

(S)-3-hydroxybutanoateReach from here →
Catalysed by SCLY, ADHFE1cytosol, mitochondrial matrix
CHEBI:1146900Reach from here →
Catalysed by SHMT1,

Page 2 of 6

BAAT

nucleus, cytosol, peroxisome

One of 32 routes

N(omega)-methyl-L-arginineReach from here →

Methionine Synthase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine

Catalysed by SHMT1, AGXT2nucleus, cytosolOne of 4 routes

3-hydroxy-2-methylpropanoateReach from here →

Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)

Catalysed by SCLY, AGXT2, HIBADHcytosol

glycoursodeoxycholateReach from here →

Methionine Synthase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
glycine to glycoursodeoxycholate conversion

Catalysed by SHMT1nucleus, cytosolOne of 2 routes

prostaglandin E3Reach from here →

Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
(S)-Lactate:NAD+ oxidoreductase
Transport of Prostaglandin E3, Lactate Antiport

Catalysed by SCLY, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 4 routes

prostaglandin A2Reach from here →

Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
(S)-Lactate:NAD+ oxidoreductase
Transport of Prostaglandin A2, Lactate Antiport

Catalysed by SCLY, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

prostaglandin J2Reach from here →

Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
(S)-Lactate:NAD+ oxidoreductase
Transport of Prostaglandin J2, Lactate Antiport

Catalysed by SCLY, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

15-oxoprostaglandin F2alphaReach from here →

Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
(S)-Lactate:NAD+ oxidoreductase
Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport

Catalysed by SCLY, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

N-(9Z-octadecenoyl)glycineReach from here →

Methionine Synthase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
(9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)

Catalysed by SHMT1, GLYATL3, GLYATL2nucleus, cytosol

N-octadecanoylglycineReach from here →

Methionine Synthase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

Catalysed by SHMT1, GLYATL2nucleus, cytosol

N-(9Z-hexadecenoyl)-glycineReach from here →

Methionine Synthase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
(9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

Catalysed by SHMT1, GLYATL2nucleus, cytosol

all-trans-4-hydroxyretinoateReach from here →

Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
transport of pyruvate and retinoate (cytosol to extracellular)
cytochrome P450 (retinoate)

Catalysed by SCLY, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular spaceOne of 3 routes

N-acetylcadaverineReach from here →

Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
transport of acetate and pyruvate (cytosol to extracellular)
N-acetylcadaverine + H2O = cadaverine + acetate

Catalysed by SCLY, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular space

all-trans-retinoyl-1-O-(beta-D-glucuronate)Reach from here →

Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
transport of pyruvate and retinoate (cytosol to extracellular)
glucuronosyltransferase (retinoate)

Catalysed by SCLY, SLC16A4, SLC16A5, SLC16A3 and 6 morecytosol, extracellular space, endoplasmic reticulum

all-trans-18-hydroxyretinoateReach from here →

Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
transport of pyruvate and retinoate (cytosol to extracellular)
unspecific monooxygenase (retinoate)

Catalysed by SCLY, SLC16A4, SLC16A5, SLC16A3 and 28 morecytosol, extracellular spaceOne of 2 routes

a phenyl acetateReach from here →

Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
transport of acetate and pyruvate (cytosol to extracellular)
a phenyl acetate + H2O = a phenol + acetate + H(+)

Catalysed by SCLY, SLC16A4, SLC16A5, SLC16A3 and 5 morecytosol, extracellular space

N-hexadecanoylglycineReach from here →

Methionine Synthase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

Catalysed by SHMT1, GLYATL3nucleus, cytosol

N-dodecanoylglycineReach from here →

Methionine Synthase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

Catalysed by SHMT1, GLYATL2nucleus, cytosol

N-decanoylglycineReach from here →

Methionine Synthase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

Catalysed by SHMT1, GLYATL2nucleus, cytosol

N-octanoylglycineReach from here →

Methionine Synthase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

Catalysed by SHMT1, GLYATL2nucleus, cytosol

2',3'-cGAMPReach from here →

Methionine Synthase
phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)
2',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 2',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)

Catalysed by ATIC, SLC19A1nucleus, cytosol, inner side of the membrane, outer side of the membrane

N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →

Methionine Synthase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

Catalysed by SHMT1, GARTnucleus, cytosol

L-cystine-bis-glycineReach from here →

Methionine Synthase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

Catalysed by SHMT1, DPEP1, DPEP2nucleus, cytosol

glycyldehydrophenylalanineReach from here →

Methionine Synthase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

Catalysed by SHMT1, DPEP1nucleus, cytosol

an N-(fatty acyl)-glycineReach from here →

Methionine Synthase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

Catalysed by SHMT1, GLYATL2nucleus, cytosol

N-(9Z,12Z-octadecadienoyl)-glycineReach from here →

Methionine Synthase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
(9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

Catalysed by SHMT1, GLYATL2nucleus, cytosol

CHEBI:15345Reach from here →

Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
transport of acetoacetate and pyruvate (cytosol to mitochondria)
Acetoacetate:CoA ligase (AMP-forming)

Catalysed by SCLY, AACScytosol, mitochondrial matrixOne of 3 routes

acetoneReach from here →

Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
transport of acetoacetate and pyruvate (cytosol to mitochondria)
Acetoacetate carboxy-lyase (acetone-forming)

Catalysed by SCLYcytosol, mitochondrial matrix

5,6,7,8-tetrahydrobiopterinReach from here →

Methionine Synthase
histamine N-methyltransferase (SAM)
5-methyl-THF to 5,10-methylene-THF conversion

Catalysed by HNMTnucleus, cytosol

propionyl-CoAReach from here →

Methionine Synthase
Selenomethionine methanethiol-lyase (deaminating)
2-oxobutyrate oxidation

Catalysed by CTHnucleus, cytosolOne of 5 routes

CHEBI:15570Reach from here →

Methionine Synthase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
transport of D-alanine and glycine (cytosol to extracellular)

Catalysed by SHMT1, SLC3A2, SLC7A10nucleus, cytosol, extracellular spaceOne of 3 routes

L-leucineReach from here →

Methionine Synthase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
transport of glycine and leucine (cytosol to extracellular)

Catalysed by SHMT1, SLC7A5nucleus, cytosol, extracellular spaceOne of 15 routes

CHEBI:15611Reach from here →

Methionine Synthase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
S-Adenosyl-L-methionine:glycine N-methyltransferase

Catalysed by SHMT1, GNMTnucleus, cytosol

CHEBI:15699Reach from here →

Methionine Synthase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
transport of glycine and homoserine (cytosol to extracellular)

Catalysed by SHMT1, SLC7A5nucleus, cytosol, extracellular spaceOne of 10 routes

malonateReach from here →

Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
(S)-malate + NAD(+) = pyruvate + CO2 + NADH
malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)

Catalysed by SCLY, ME2, SLC25A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

CHEBI:15971Reach from here →

Methionine Synthase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
transport of glycine and histidine (cytosol to extracellular)

Catalysed by SHMT1, SLC7A6nucleus, cytosol, extracellular spaceOne of 6 routes

selenophosphateReach from here →

S-Adenosyl-L-methionine:thiol S-methyltransferase
L-selenocysteine selenide-lyase (L-alanine-forming)
ATP:selenide, water phosphotransferase

Catalysed by SCLY, SEPHS1, SEPHS2cytosol

CHEBI:16174Reach from here →

Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
pyruvate kinase (dTDP)
nucleoside-diphosphate kinase (dADP)

Catalysed by SCLY, PKM, PKLR, NME4 and 5 morecytosolOne of 3 routes

sulfateReach from here →

Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
(S)-malate + NAD(+) = pyruvate + CO2 + NADH
transport of malate and sulfate (cytosol to mitochondria)

Catalysed by SCLY, ME2, SLC25A10cytosol, mitochondrial matrixOne of 4 routes

L-cystineReach from here →

S-Adenosyl-L-methionine:thiol S-methyltransferase
L-selenocysteine selenide-lyase (L-alanine-forming)
Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

Catalysed by SCLY, SLC7A9, SLC3A1cytosol, extracellular space

CHEBI:16284Reach from here →

Se-methyl-L-selenocysteine methaneselenol-lyase (deaminating
pyruvate kinase (dTDP)
deoxythymidylate kinase (dADP)

Catalysed by SCLY, PKM, PKLR, DTYMKcytosol, mitochondrial matrixOne of 3 routes

(R)-3-aminoisobutyric acidReach from here →

S-Adenosyl-L-methionine:thiol S-methyltransferase
L-selenocysteine selenide-lyase (L-alanine-forming)
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

Catalysed by SCLY, AGXT2cytosol, mitochondrial matrixOne of 3 routes

L-citrullineReach from here →

Methionine Synthase
5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
transport of citrulline and glycine (cytosol to extracellular)

Catalysed by SHMT1, SLC7A9, SLC3A1, SLC7A6nucleus, cytosol, extracellular spaceOne of 5 routes