L-cysteinylglycine

Three steps

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC3A2 and 3 morecytosol, extracellular space

• kinetensinReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. Chymase

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5 and 1 morecytosol, extracellular spaceOne of 3 routes

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serineReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol, extracellular space

• (7Z)-octadecenoyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 3 morecytosol, mitochondrial matrixOne of 3 routes

• (15S)-15-hydroperoxy-prostaglandin E2Reach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  3. prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol, extracellular space

• acetaldehydeReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and threonine (cytosol to extracellular)
  3. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5cytosol, extracellular spaceOne of 2 routes

• CHEBI:15345Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 1 morecytosol, mitochondrial matrixOne of 2 routes

• cholineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 1 morecytosol, mitochondrial matrix, nucleusOne of 7 routes

• acetylpyruvateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by ANPEP, LAP3, NPEPPS, CTH and 1 morecytosol

• all-trans-retinoic acidReach from here →
  1. L-cysteinylglycine dipeptidase
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. transport of pyruvate and retinoate (cytosol to extracellular)

  Catalysed by ANPEP, LAP3, NPEPPS, CTH and 6 morecytosol, extracellular spaceOne of 2 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5 and 2 morecytosol, extracellular spaceOne of 3 routes

• CHEBI:15380Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 2 morecytosol, mitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 3 morecytosol, mitochondrial matrixOne of 3 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Production of Tiglylcarnitine

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 2 morecytosol, mitochondrial matrixOne of 2 routes

• isobutyryl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 3 morecytosol, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 1 morecytosol, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 3 morecytosol, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 8 morecytosol, mitochondrial matrixOne of 14 routes

• CHEBI:15519Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. propanoyl-CoA C-acyltransferase

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 3 morecytosol, mitochondrial matrix, peroxisomeOne of 3 routes

• palmitoyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 8 morecytosol, mitochondrial matrixOne of 11 routes

• oleoyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 3 morecytosol, mitochondrial matrixOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Phenylacetate:CoA ligase

  Catalysed by ANPEP, LAP3, NPEPPS, NAGScytosol, mitochondrial matrixOne of 4 routes

• propionyl-CoAReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 3 morecytosol, mitochondrial matrixOne of 43 routes

• (S)-malateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. (S)-malate + NAD(+) = pyruvate + CO2 + NADH

  Catalysed by ANPEP, LAP3, NPEPPS, CTH and 1 morecytosolOne of 6 routes

• 12(S)-HPETEReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. arachidonate:oxygen 12-oxidoreductase

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular spaceOne of 4 routes

• 15(S)-HPETEReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. Glutathione: 5-HPETE oxidoreductase
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 11 morecytosolOne of 7 routes

• 5(S)-HPETEReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. Arachidonate:oxygen 5-oxidoreductase

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular space

• (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by ANPEP, LAP3, NPEPPS, SHMT1 and 1 morecytosolOne of 2 routes

• 10-formyltetrahydrofolic acidReach from here →
  1. L-cysteinylglycine dipeptidase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by ANPEP, LAP3, NPEPPS, SHMT1 and 1 morecytosolOne of 3 routes

• 5-methyltetrahydrofolic acidReach from here →
  1. L-cysteinylglycine dipeptidase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. histamine N-methyltransferase (SAM)

  Catalysed by ANPEP, LAP3, NPEPPS, SHMT1 and 1 morecytosol

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5 and 2 morecytosol, extracellular spaceOne of 3 routes

• betaine aldehydeReach from here →
  1. L-cysteinylglycine dipeptidase
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. choline + A = betaine aldehyde + AH2

  Catalysed by ANPEP, LAP3, NPEPPS, MOCOS and 1 morecytosol

• trimethylenediamineReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and lysine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A6 and 1 morecytosol, extracellular space

• CHEBI:15727Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 1 morecytosol, mitochondrial matrixOne of 3 routes

• formateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. alcohol dehydrogenase (formaldehyde)
  3. S-formylglutathione + H2O = formate + glutathione + H(+)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 9 morecytosol

• CHEBI:15746Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 2 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:15765Reach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5 and 1 morecytosol, extracellular spaceOne of 5 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol

• alpha-D-glucosamine 6-phosphateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and glutamine (cytosol to extracellular)
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC3A2 and 4 morecytosol, extracellular space

• thioredoxin dithiolReach from here →
  1. L-cysteinylglycine dipeptidase
  2. L-Cysteine:tRNA(Cys) ligase (AMP-forming)
  3. glycyl-tRNA(gly) phosphorylation

  Catalysed by ANPEP, LAP3, NPEPPS, CARS1cytosolOne of 6 routes

• (R)-lactateReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 5 morecytosol

• methanethiolReach from here →
  1. L-cysteinylglycine dipeptidase
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)

  Catalysed by ANPEP, LAP3, NPEPPS, CTH and 1 morecytosol

• sulfateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. hydrogen sulfide + 2 O2 = sulfate + H(+)

  Catalysed by ANPEP, LAP3, NPEPPS, CTH and 1 morecytosolOne of 10 routes

• ureaReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of arginine and cysteine (cytosol to extracellular)
  3. L-Arginine amidinohydrolase

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A6 and 1 morecytosol, extracellular spaceOne of 6 routes

• dimethylarsinateReach from here →
  1. glutathione = L-cysteinylglycine + 5-oxo-L-proline
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  3. methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by CHAC2, CHAC1, GSTO1, GSTO2 and 1 more

• 2-methyl-3-oxopropanoic acidReach from here →
  1. L-cysteinylglycine dipeptidase
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by ANPEP, LAP3, NPEPPS, CTH and 1 morecytosol, mitochondrial matrixOne of 3 routes

• 11-cis-retinolReach from here →
  1. L-cysteinylglycine dipeptidase
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by ANPEP, LAP3, NPEPPS, NAGS and 5 morecytosol, mitochondrial matrix

• cob(II)alaminReach from here →
  1. gamma-glutamyltransferase (alanine)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 4 morecytosol

• iodideReach from here →
  1. L-cysteinylglycine dipeptidase
  2. transport of cysteine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by ANPEP, LAP3, NPEPPS, SLC7A5 and 1 morecytosol, extracellular spaceOne of 34 routes

• oxaloacetateReach from here →
  1. L-cysteinylglycine dipeptidase
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. Pyruvate:carbon-dioxide ligase (ADP-forming)

  Catalysed by ANPEP, LAP3, NPEPPS, CTH and 1 morecytosol, mitochondrial matrixOne of 10 routes