guanidinoacetate

Three steps

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by GATM, GSS, MGST3cytosol

• (6R)-10-formyltetrahydrofolateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
  3. (6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate

  Catalysed by GATM, SHMT1, SHMT2, MTHFD1 and 1 morecytosol

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by GATM, GSS, GPX1, GPX4cytosol

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by GATM, GSS, GPX1, GPX4cytosol

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by GATM, GSS, GPX1, GPX4cytosol

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by GATM, GSS, GPX1, GPX4cytosol

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by GATM, GSS, GPX4cytosol

• biocytinReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)
  3. biocytin + H2O = biotin + L-lysine

  Catalysed by GATM, SLC7A9, SLC25A29, SLC7A6 and 1 morecytosol, inner side of the membrane, outer side of the membrane

• glycodeoxycholate 3-sulfateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. Glycodeoxycholate amidohydrolase
  3. glycodeoxycholate + 3'-phosphoadenylyl sulfate = glycodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by GATM, SULT2A1cytosol

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. N(omega),N(omega)-dimethyl-L-arginine(in) + L-arginine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-arginine(in)
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by GATM, SLC25A2, AGXT2cytosol, inner side of the membrane, outer side of the membraneOne of 7 routes

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by GATM, AADAT, AGXT2cytosolOne of 3 routes

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. N(omega)-methyl-L-arginine(in) + L-arginine(out) = N(omega)-methyl-L-arginine(out) + L-arginine(in)
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by GATM, SLC25A29, AGXT2cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• (6R)-5,10-methylenetetrahydrofolic acidReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by GATM, SHMT1cytosolOne of 7 routes

• S-disulfanyl-L-cysteineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. transport of arginine and cysteine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by GATM, SLC7A6, CARS2cytosol, extracellular space

• (5Z)-dodecenoyl-CoAReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. bile acid-CoA: amino acid N-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by GATM, BAAT, HADHA, ACAA2 and 1 morecytosol, peroxisome, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. L-Arginine:glycine amidinotransferase
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by GATM, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by GATM, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by GATM, BAAT, HADHA, ACADVL and 1 morecytosol, peroxisome, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by GATM, BAAT, HADHA, ACADVL and 1 morecytosol, peroxisome, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by GATM, BAAT, ECHS1, ACAA2 and 1 morecytosol, peroxisome, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by GATM, BAAT, ECHS1, ACAA2 and 1 morecytosol, peroxisome, mitochondrial matrixOne of 2 routes

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by GATM, GSS, GSTP1cytosol

• glycoursodeoxycholate 3-sulfateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. glycine to glycoursodeoxycholate conversion
  3. glycoursodeoxycholate + 3'-phosphoadenylyl sulfate = glycoursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by GATM, SULT2A1cytosol

• glycochenodeoxycholate 3-sulfateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)
  3. glycochenodeoxycholate + 3'-phosphoadenylyl sulfate = glycochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by GATM, BAAT, SULT2A1cytosol

• deoxycholateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. Glycodeoxycholate amidohydrolase
  3. Glycodeoxycholate amidohydrolase

  Catalysed by GATMcytosol

• a quinolReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by GATM, GSS, SQORcytosol

• alpha-linolenic acidReach from here →
  1. Transport of Guanidinoacetic Acid
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC6A14extracellular space, cytosol, endoplasmic reticulum

• folic acidReach from here →
  1. Transport of Guanidinoacetic Acid
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Folate Transport by Oats

  Catalysed by SLC26A6, SLC22A8, SLC22A7extracellular space, cytosolOne of 2 routes

• CHEBI:27540Reach from here →
  1. L-Arginine:glycine amidinotransferase
  2. bile acid-CoA: amino acid N-acyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by GATM, BAAT, ACSM4, ACSM1 and 4 morecytosol, peroxisomeOne of 6 routes

• elaidic acidReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. bile acid-CoA: amino acid N-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by GATM, BAAT, SLC27A2, ACSL4 and 6 morecytosol, peroxisomeOne of 5 routes

• 5-hydroxytryptophanReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. transport of arginine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by GATM, SLC7A6, TPH1, TPH2cytosol, extracellular spaceOne of 2 routes

• 5(S)-HETEReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by GATM, GSS, GPX5, GPX1 and 7 morecytosolOne of 2 routes

• CHEBI:28701Reach from here →
  1. L-Arginine:glycine amidinotransferase
  2. bile acid-CoA: amino acid N-acyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by GATM, BAAT, ACAA1, SCP2 and 1 morecytosol, peroxisomeOne of 7 routes

• pyridoxine 5'-phosphateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. transport of alanine and arginine (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by GATM, SLC7A6, SCLYcytosol, extracellular space

• 3-disulfanyl-L-alanineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)
  3. L-cystine thiocysteine-lyase (deaminating

  Catalysed by GATM, SLC7A9, CTHcytosol, inner side of the membrane, outer side of the membrane

• N-acetyl-L-cysteineReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. transport of arginine and cysteine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by GATM, SLC7A6, NAGScytosol, extracellular space, mitochondrial matrix

• a dicarboxylateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. Hippurate (Benzoylglycinate) Formation
  3. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)

  Catalysed by GATM, SLC22A6, SLC22A8cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 4 routes

• L-ascorbic acidReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by GATM, GSS, CLIC1, GSTO1 and 1 morecytosol

• K(+)Reach from here →
  1. L-Arginine:glycine amidinotransferase
  2. transport of arginine and cysteine (cytosol to extracellular)
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by GATM, SLC7A6, SLC1A1cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• Ca(2+)Reach from here →
  1. Transport of Guanidinoacetic Acid
  2. transport of chloride (cytosol to extracellular)
  3. transport of Ca2+ and K+ (cytosol to extracellular)

  Catalysed by SLC12A2, SLC12A1, SLC24A1, SLC24A5 and 3 moreextracellular space, cytosol

• Cys-tRNA(Cys)Reach from here →
  1. L-Arginine:glycine amidinotransferase
  2. transport of arginine and cysteine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by GATM, SLC7A6, CARS1cytosol, extracellular space

• Phe-tRNA(Phe)Reach from here →
  1. L-Arginine:glycine amidinotransferase
  2. transport of arginine and phenylalanine (cytosol to extracellular)
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by GATM, SLC7A6, FARSB, FARSAcytosol, extracellular space

• Trp-tRNA(Trp)Reach from here →
  1. L-Arginine:glycine amidinotransferase
  2. transport of arginine and tryptophan (cytosol to extracellular)
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by GATM, SLC7A6, WARS1cytosol, extracellular space

• Ile-tRNA(Ile)Reach from here →
  1. L-Arginine:glycine amidinotransferase
  2. transport of arginine and isoleucine (cytosol to extracellular)
  3. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by GATM, SLC7A6, IARS1cytosol, extracellular space

• Gln-tRNA(Gln)Reach from here →
  1. L-Arginine:glycine amidinotransferase
  2. transport of arginine and glutamine (cytosol to extracellular)
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by GATM, SLC7A6, QARS1cytosol, extracellular space

• isocyanateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)
  3. L-citrulline + H(+) = isocyanate + L-ornithine

  Catalysed by GATM, NOS3, NOS1, NOS2 and 1 morecytosol

• hypoioditeReach from here →
  1. Transport of Guanidinoacetic Acid
  2. transport of chloride and iodide (cytosol to extracellular)
  3. iodide + H2O2 = hypoiodite + H2O

  Catalysed by SLC26A4, MPO, LPOextracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. L-Arginine:glycine amidinotransferase
  2. transport of arginine and asparagine (cytosol to extracellular)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by GATM, SLC7A6, NARS1cytosol, extracellular space

• phosphocholineReach from here →
  1. Transport of Guanidinoacetic Acid
  2. transport of chloride and choline (cytosol to extracellular)
  3. phosphocholine + H2O = choline + phosphate

  Catalysed by SLC5A7, PHOSPHO1extracellular space, cytosolOne of 2 routes

• cholateReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. solute carrier organic anion transporter (cholate)

  Catalysed by GATM, GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 3 routes