N(6)-(1,2-dicarboxyethyl)-AMP

Three steps

• quinolinic acidReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. Transport of Quinolinic Acid

  Catalysed by ADSL, TNRC6B, SLC25A10, SLC22A6cytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• uridineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. IMP + H2O = inosine + phosphate
  3. inosine + UMP = uridine + IMP

  Catalysed by ADSS2, ADSS1, NT5E, NT5C2 and 2 more

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by ADSS2, ADSS1, SLC7A13, AADATinner side of the membrane, outer side of the membrane

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by ADSS2, ADSS1, SLC7A13, CNDP2inner side of the membrane, outer side of the membrane

• guanosineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. IMP + H2O = inosine + phosphate
  3. inosine + GMP = guanosine + IMP

  Catalysed by ADSS2, ADSS1, NT5E, NT5C2 and 2 more

• tryptamineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-tryptophan decarboxy-lyase

  Catalysed by ADSS2, ADSS1, SLC7A13, DDCinner side of the membrane, outer side of the membrane, cytosol

• 2-oxoglutaramateReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by ADSS2, ADSS1, SLC7A13, KYAT1inner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• CHEBI:16857Reach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and threonine (cytosol to extracellular)

  Catalysed by ADSS2, ADSS1, ASNS, SLC7A5cytosol, extracellular spaceOne of 34 routes

• ferrocytochrome cReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. sulfite:ferricytochrome-c oxidoreductase

  Catalysed by ADSL, TNRC6B, SLC25A10, SUOXcytosol, mitochondrial matrix

• oxalic acidReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. transport of oxalate and sulfate (cytosol to extracellular)

  Catalysed by ADSL, TNRC6B, SLC25A10, SLC26A6cytosol, mitochondrial matrix, extracellular space

• 4-maleylacetoacetateReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)
  3. 4-maleylacetoacetate = 4-fumarylacetoacetate

  Catalysed by ADSL, TNRC6B, FAH, GSTZ1cytosol

• 2'-deoxyguanosineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. IMP + H2O = inosine + phosphate
  3. dGMP + inosine = 2'-deoxyguanosine + IMP

  Catalysed by ADSS2, ADSS1, NT5E, NT5C2 and 2 moreOne of 6 routes

• L-isoleucineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and isoleucine (cytosol to extracellular)

  Catalysed by ADSS2, ADSS1, ASNS, SLC7A5cytosol, extracellular spaceOne of 34 routes

• CHEBI:17202Reach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. IMP + H2O = inosine + phosphate
  3. ATP:inosine 5'-phosphotransferase

  Catalysed by ADSS2, ADSS1, NT5E, NT5C2 and 2 moremitochondrial matrixOne of 2 routes

• anilineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by ADSS2, ADSS1, NAT8L, NAT2 and 1 moremitochondrial matrix, cytosol

• CHEBI:17312Reach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by ADSS2, ADSS1, NAT8Lmitochondrial matrix, cytosolOne of 2 routes

• D-aspartic acidReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. transport of aspartate (cytosol to extracellular)
  3. transport of D-aspartate (cytosol to extracellular)

  Catalysed by ADSS2, ADSS1, SLC1A7, SLC1A3 and 3 moreextracellular space, cytosol

• hypoxanthineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. IMP + H2O = inosine + phosphate
  3. inosine:phosphate alpha-D-ribosyltransferase

  Catalysed by ADSS2, ADSS1, NT5E, NT5C2 and 3 morecytosolOne of 2 routes

• CHEBI:17380Reach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by ADSS2, ADSS1, SLC7A13, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. a quinone + succinate = fumarate + a quinol
  3. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)

  Catalysed by ADSL, TNRC6B, SDHB, PRODH and 1 morecytosolOne of 3 routes

• enol-oxaloacetateReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by ADSL, TNRC6B, FH, SDHB and 1 morecytosolOne of 3 routes

• AH2Reach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by ADSS2, ADSS1, SLC7A13, CDKAL1inner side of the membrane, outer side of the membraneOne of 4 routes

• L-cysteineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and cysteine (cytosol to extracellular)

  Catalysed by ADSS2, ADSS1, ASNS, SLC7A5cytosol, extracellular spaceOne of 50 routes

• cytidineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. IMP + H2O = inosine + phosphate
  3. inosine + CMP = cytidine + IMP

  Catalysed by ADSS2, ADSS1, NT5E, NT5C2 and 2 more

• indole-3-pyruvateReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by ADSS2, ADSS1, SLC7A13, IL4I1inner side of the membrane, outer side of the membraneOne of 2 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. Steryl-Sulfatase

  Catalysed by ADSL, TNRC6B, SLC25A10, STScytosol, mitochondrial matrix, Golgi apparatusOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by ADSS2, ADSS1, NAT8L, HADHA and 2 moremitochondrial matrix

• Ala-tRNA(Ala)Reach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by ADSS2, ADSS1, AGXT2, AARS1cytosol

• 5-hydroxy-L-tryptophanReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by ADSS2, ADSS1, SLC7A13, TPH1 and 1 moreinner side of the membrane, outer side of the membrane

• 4-methyl-2-oxopentanoateReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by ADSS2, ADSS1, SLC7A13, BCAT2inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 4 routes

• CHEBI:17895Reach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and tyrosine (cytosol to extracellular)

  Catalysed by ADSS2, ADSS1, ASNS, SLC7A5cytosol, extracellular spaceOne of 34 routes

• CHEBI:17927Reach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by ADSS2, ADSS1, NAT8Lmitochondrial matrix, cytosol

• 3-oxopropanoic acidReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate 1-carboxy-lyase (beta-alanine-forming)
  3. beta-alanine:2-oxoglutarate aminotransferase

  Catalysed by ADSS2, ADSS1, GAD2, ABATcytosol, mitochondrial matrix

• ubiquinolReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. succinate:quinone oxidoreductase
  3. thioredoxin-disulfide reductase (NADPH) (ubiquinone)

  Catalysed by ADSL, TNRC6B, SDHD, SDHB and 4 morecytosol, mitochondrial matrixOne of 6 routes

• 3-phenylpyruvateReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by ADSS2, ADSS1, SLC7A13, GOT2 and 1 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 5 routes

• CHEBI:18019Reach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and lysine (cytosol to extracellular)

  Catalysed by ADSS2, ADSS1, ASNS, SLC7A6cytosol, extracellular spaceOne of 18 routes

• thiocyanateReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. transport of fumarate and thiosulfate (cytosol to mitochondria)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by ADSL, TNRC6B, SLC25A10, MPST and 1 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:18095Reach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. Aspartate Intake by System Asct-1 Transporter
  3. prolyl 4-hydroxylase (AKG)

  Catalysed by ADSS2, ADSS1, P4HA2, P4HB and 1 moreextracellular space, cytosol, endoplasmic reticulumOne of 4 routes

• xanthosineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. IMP + NAD(+) + H2O = XMP + NADH + H(+)
  3. xanthosine 5'-phosphate phosphohydrolase

  Catalysed by ADSS2, ADSS1, IMPDH2, IMPDH1 and 8 morecytosolOne of 2 routes

• 2-phenylethylamineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by ADSS2, ADSS1, SLC7A13, DDCinner side of the membrane, outer side of the membrane, cytosol

• hydrogen cyanideReach from here →
  1. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. thiosulfate:cyanide sulfurtranserase

  Catalysed by ADSL, TNRC6B, SLC25A10, MPST and 1 morecytosol, mitochondrial matrixOne of 2 routes

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by ADSS2, ADSS1, SLC7A13, PFASinner side of the membrane, outer side of the membrane, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by ADSS2, ADSS1, SLC7A13, SLC7A8inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by ADSS2, ADSS1, AGXT2, SLC7A10inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by ADSS2, ADSS1, GOT2, AGXT2mitochondrial matrixOne of 7 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by ADSS2, ADSS1, AGXT2

• (5Z)-dodecenoyl-CoAReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by ADSS2, ADSS1, NAT8L, HADHA and 2 moremitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by ADSS2, ADSS1, NAT8L, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by ADSS2, ADSS1, NAT8L, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by ADSS2, ADSS1, NAT8L, HADHA and 2 moremitochondrial matrixOne of 3 routes