L-dopa

Three steps

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming)

  Catalysed by SLC7A8, SLC7A13, PAICSinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• L-thyroxineReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• kynurenateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Phenylalanine Transaminase, Mitochondrial
  3. 3-phenylpyruvate + L-kynurenine = kynurenate + L-phenylalanine + H2O

  Catalysed by SLC7A8, GOT2, TAT, AADATinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 14 routes

• L-2-aminohexanoateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Transport of L-Kynurenine
  3. 2-oxohexanoate + L-kynurenine = L-2-aminohexanoate + kynurenate + H2O

  Catalysed by SLC7A8, AADATinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 5-guanidino-2-oxopentanoateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of arginine and phenylalanine (cytosol to extracellular)
  3. L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)

  Catalysed by SLC7A8, SLC7A6, IL4I1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• S-sulfanyl-L-cysteineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by SLC7A8, SLC7A5, CARS2inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N-formyl-L-kynurenineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 = N-formyl-L-kynurenine

  Catalysed by SLC7A8, SLC7A5, IDO1, TDO2 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• L-2-aminoadipateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Transport of L-Kynurenine
  3. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O

  Catalysed by SLC7A8, AADATinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 5-phospho-beta-D-ribosylamineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. phosphoribosyl pyrophosphate amidotransferase (glutamine)

  Catalysed by SLC7A8, SLC7A5, PPATinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• D-glucosamine 6-phosphateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate

  Catalysed by SLC7A8, SLC7A5, GFPT2, GFPT1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• L-methionine (S)-S-oxideReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by SLC7A8, SLC7A5, MSRAinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• L-methionine (R)-S-oxideReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by SLC7A8, SLC7A5, MSRB3, MSRB1 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• 5-amino-2-oxopentanoateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by SLC7A8, SLC7A6, AGXT2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• S-sulfanylglutathioneReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by DDC, SLCO1A2, SLCO1B3, SQORextracellular space, cytosol, mitochondrial matrix

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by SLC7A8, SLC7A5, GLYATL2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by SLC7A8, SLC7A5, PPCSinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• (6R)-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by SLC7A8, PAH, TPH1, TPH2inner side of the membrane, outer side of the membraneOne of 3 routes

• an L-alpha-amino acidReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Transport of L-Kynurenine
  3. an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)

  Catalysed by SLC7A8, SLC7A11inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• 4-aminobutanoateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by SLC7A8, SLC6A14, SLC6A12inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

• 3-iodo-L-tyrosineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of phenylalanine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by SLC7A8, SLC7A5, TPOinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• L-prolineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by SLC7A8, SLC7A5, SLC1A4inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• estrone 3-sulfateReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 2 routes

• prostaglandin E2Reach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of prostaglandin E2 (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• N-benzoylglycineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by SLC7A8, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by SLC7A8, SLC7A5, CDO1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 6 routes

• L-cysteinylglycineReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by DDC, SLCO1A2, SLCO1B3, GGTLC3 and 5 moreextracellular space, cytosolOne of 6 routes

• N(5)-[(Z)-amino(hydroxyimino)methyl]ornithineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of arginine and phenylalanine (cytosol to extracellular)
  3. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

  Catalysed by SLC7A8, SLC7A6, NOS3, NOS1 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• Mo-molybdopterinReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SLC7A8, SLC7A5, MOCOSinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• (R)-adrenalineReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
  3. (R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + S-adenosyl-L-homocysteine + H(+)

  Catalysed by DDC, DBH, PNMTcytosol

• (2S)-2-aminobutanoateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine

  Catalysed by SLC7A8, SLC7A5, AGXT2inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 3 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5

  Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• ursodeoxycholateReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• 3-phenyllactateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. Phenylalanine Transaminase, Mitochondrial
  3. Formation of Phenyl-Lactate

  Catalysed by SLC7A8, GOT2, TATinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosol

• prostaglandin G2Reach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of prostaglandin G2 (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• thio-Mo-molybdopterinReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SLC7A8, SLC7A5, MOCOSinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• glycodeoxycholateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. Glycodeoxycholate amidohydrolase

  Catalysed by SLC7A8, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

• (R)-lipoateReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
  3. ascorbate to dehydroascorbic acid conversion

  Catalysed by DDC, DBHcytosol

• N-tetradecanoylglycineReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O
  3. N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by DDC, DBH, PAMOne of 2 routes

• N-eicosanoylglycinateReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by SLC7A8, SLC7A5, BAATinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N-docosanoylglycineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by SLC7A8, SLC7A5, BAATinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• N-hexacosanoylglycineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

  Catalysed by SLC7A8, SLC7A5, BAATinner side of the membrane, outer side of the membrane, extracellular space, cytosol

• an N(2)-acyl-L-glutamineReach from here →
  1. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by SLC7A8, SLC7A5, GLYATL1B, GLYATL1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

• thromboxane B2Reach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by DDC, SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• taurochenodeoxycholateReach from here →
  1. L-dopa + H(+) = dopamine + CO2
  2. transport of dopamine (cytosol to extracellular)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by DDC, SLCO1A2, SLCO1B3, SLC7A9extracellular space, cytosolOne of 4 routes