1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one

Three steps

• cholineReach from here →
  1. acireductone dioxygenase
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of chloride and choline (cytosol to extracellular)

  Catalysed by ADI1, SLC26A4, SLC5A7cytosol, extracellular space

• acetylpyruvateReach from here →
  1. acireductone dioxygenase
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular spaceOne of 2 routes

• propionyl-CoAReach from here →
  1. acireductone dioxygenase
  2. transport of formate and propanoate (cytosol to extracellular)
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A1 and 3 morecytosol, extracellular spaceOne of 3 routes

• (S)-malateReach from here →
  1. acireductone dioxygenase
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. (S)-malate + NAD(+) = pyruvate + CO2 + NADH

  Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular spaceOne of 3 routes

• L-leucineReach from here →
  1. acireductone dioxygenase
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of chloride and leucine (cytosol to extracellular)

  Catalysed by ADI1, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 8 routes

• CHEBI:15699Reach from here →
  1. Acireductone Dixoygenase 1
  2. tyrosine aminotransferase (4-methylthio-2-oxobutanoic acid)
  3. transport of homoserine and methionine (cytosol to extracellular)

  Catalysed by ADI1, TAT, SLC7A5cytosol, extracellular spaceOne of 3 routes

• CHEBI:15971Reach from here →
  1. acireductone dioxygenase
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of chloride and histidine (cytosol to extracellular)

  Catalysed by ADI1, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 3 routes

• sulfateReach from here →
  1. acireductone dioxygenase
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by ADI1, SLC26A4, SLC26A6cytosol, extracellular spaceOne of 3 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. acireductone dioxygenase
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space, mitochondrial matrix

• L-citrullineReach from here →
  1. Acireductone Dixoygenase 1
  2. tyrosine aminotransferase (4-methylthio-2-oxobutanoic acid)
  3. transport of citrulline and methionine (cytosol to extracellular)

  Catalysed by ADI1, TAT, SLC7A6cytosol, extracellular spaceOne of 2 routes

• iodideReach from here →
  1. acireductone dioxygenase
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by ADI1, SLC26A4cytosol, extracellular space

• L-valineReach from here →
  1. acireductone dioxygenase
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by ADI1, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 5 routes

• oxaloacetateReach from here →
  1. acireductone dioxygenase
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. Pyruvate:carbon-dioxide ligase (ADP-forming)

  Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space, mitochondrial matrixOne of 3 routes

• L-arginineReach from here →
  1. acireductone dioxygenase
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by ADI1, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 7 routes

• protein polypeptide chainReach from here →
  1. Acireductone Dixoygenase 1
  2. tyrosine aminotransferase (4-methylthio-2-oxobutanoic acid)
  3. PROTEIN_BS

  Catalysed by ADI1, TATcytosol

• N(2)-acetyl-L-ornithineReach from here →
  1. acireductone dioxygenase
  2. transport of acetate and formate (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A1 and 1 morecytosol, extracellular space

• Met-tRNA(Met)Reach from here →
  1. Acireductone Dixoygenase 1
  2. tyrosine aminotransferase (4-methylthio-2-oxobutanoic acid)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by ADI1, TAT, MARS1cytosol

• (S)-lactateReach from here →
  1. acireductone dioxygenase
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A7 and 7 morecytosol, extracellular space

• 2-oxobutanoateReach from here →
  1. acireductone dioxygenase
  2. transport of 2-hydroxybutyrate and formate (cytosol to extracellular)
  3. 2-hydroxybutyrate:NAD+ oxidoreductase

  Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A7 and 5 morecytosol, extracellular spaceOne of 3 routes

• 2-oxoglutaramateReach from here →
  1. acireductone dioxygenase
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular spaceOne of 2 routes

• 3-fumarylpyruvateReach from here →
  1. acireductone dioxygenase
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space

• CHEBI:16856Reach from here →
  1. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
  2. S-formylglutathione + H2O = formate + glutathione + H(+)
  3. S-Formylglutathione hydrolase

  Catalysed by ADI1, ESDcytosolOne of 2 routes

• CHEBI:16857Reach from here →
  1. acireductone dioxygenase
  2. transport of chloride and formate (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by ADI1, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 4 routes

• ferrocytochrome cReach from here →
  1. acireductone dioxygenase
  2. transport of formate and L-lactate (cytosol to extracellular)
  3. (S)-Lactate:ferricytochrome-c 2-oxidoreductase

  Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular space, mitochondrial matrix

• oxalic acidReach from here →
  1. acireductone dioxygenase
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by ADI1, SLC26A4, SLC26A6cytosol, extracellular space

• 3-hydroxypyruvateReach from here →
  1. acireductone dioxygenase
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space

• L-isoleucineReach from here →
  1. acireductone dioxygenase
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by ADI1, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 5 routes

• CHEBI:17203Reach from here →
  1. acireductone dioxygenase
  2. transport of chloride and formate (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by ADI1, SLC26A4, CLTRN, SLC6A20cytosol, extracellular spaceOne of 5 routes

• 17alpha-hydroxyprogesteroneReach from here →
  1. acireductone dioxygenase
  2. transport of acetate and formate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A1 and 1 morecytosol, extracellular space, endoplasmic reticulum

• aceneuramateReach from here →
  1. acireductone dioxygenase
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A7 and 3 morecytosol, extracellular space

• 5'-deoxyadenosineReach from here →
  1. acireductone dioxygenase
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A7 and 4 morecytosol, extracellular space

• AH2Reach from here →
  1. Acireductone Dixoygenase 1
  2. tyrosine aminotransferase (4-methylthio-2-oxobutanoic acid)
  3. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by ADI1, TAT, CDKAL1cytosolOne of 3 routes

• L-cysteineReach from here →
  1. acireductone dioxygenase
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of chloride and cysteine (cytosol to extracellular)

  Catalysed by ADI1, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 8 routes

• indole-3-pyruvateReach from here →
  1. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)
  2. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine
  3. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine

  Catalysed by ADI1, AADAT

• CHEBI:17724Reach from here →
  1. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
  2. formaldehyde + NAD(+) + H2O = formate + NADH + 2 H(+)
  3. dimethylglycine dehydrogenase (formaldehyde)

  Catalysed by ADI1, ALDH9A1, PDPR, DMGDHcytosol

• glycine betaineReach from here →
  1. acireductone dioxygenase
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by ADI1, SLC26A4, SLC6A12cytosol, extracellular spaceOne of 3 routes

• 4-methylumbelliferyl acetateReach from here →
  1. acireductone dioxygenase
  2. transport of acetate and formate (cytosol to extracellular)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A1 and 3 morecytosol, extracellular space

• urateReach from here →
  1. acireductone dioxygenase
  2. transport of formate and L-lactate (cytosol to extracellular)
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A3 and 4 morecytosol, extracellular space

• 4-methyl-2-oxopentanoateReach from here →
  1. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)
  2. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine
  3. L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine

  Catalysed by ADI1, AADAT

• CHEBI:17895Reach from here →
  1. acireductone dioxygenase
  2. transport of chloride and formate (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by ADI1, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 6 routes

• all-trans-retinalReach from here →
  1. acireductone dioxygenase
  2. transport of formate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by ADI1, SLC16A4, SLC16A5cytosol, extracellular space

• 3-phenylpyruvateReach from here →
  1. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)
  2. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine
  3. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine

  Catalysed by ADI1, AADAT

• CHEBI:18019Reach from here →
  1. acireductone dioxygenase
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by ADI1, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 3 routes

• 4-fumarylacetoacetateReach from here →
  1. acireductone dioxygenase
  2. transport of acetoacetate and formate (cytosol to extracellular)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by ADI1, SLC16A4, SLC16A5, FAHcytosol, extracellular space

• L-glutamineReach from here →
  1. acireductone dioxygenase
  2. transport of chloride and formate (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by ADI1, SLC26A4, SLC6A14cytosol, extracellular spaceOne of 7 routes

• dTDPReach from here →
  1. acireductone dioxygenase
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. pyruvate kinase (dTDP)

  Catalysed by ADI1, SLC16A4, SLC16A5, SLC16A7 and 4 morecytosol, extracellular space

• CHEBI:18095Reach from here →
  1. acireductone dioxygenase
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by ADI1, SLC26A4, CLTRN, SLC6A20cytosol, extracellular space

• N-carbamoyl-beta-alanineReach from here →
  1. acireductone dioxygenase
  2. transport of chloride and formate (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by ADI1, SLC26A4cytosol, extracellular spaceOne of 2 routes

• N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. acireductone dioxygenase
  2. Formate:tetrahydrofolate ligase (ADP-forming)
  3. 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase

  Catalysed by ADI1, MTHFD1, GARTcytosol

• CHEBI:18381Reach from here →
  1. acireductone dioxygenase
  2. Formate:tetrahydrofolate ligase (ADP-forming)
  3. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)

  Catalysed by ADI1, MTHFD1, ATICcytosol