a thiol

Three steps

• an acylcholineReach from here →
  1. a thioester + H2O = a thiol + a carboxylate + H(+)
  2. a thioester + H2O = a thiol + a carboxylate + H(+)
  3. an acylcholine + H2O = a carboxylate + choline + H(+)

  Catalysed by PNKD, BCHE

• glycochenodeoxycholateReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by SUMF1, TSTD1, ABCC4inner side of the membrane, outer side of the membrane

• taurocholateReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by SUMF1, TSTD1, ABCC4inner side of the membrane, outer side of the membrane

• tert-butanolReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by SUMF1, TSTD1, CLIC2, GPX1 and 3 more

• L-ornithineReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of cysteine and ornithine (cytosol to extracellular)

  Catalysed by SUMF1, CBS, SLC7A6cytosol, extracellular spaceOne of 2 routes

• 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamideReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  3. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol

  Catalysed by SUMF1, SQOR, NQO2

• a 3-acylpyruvateReach from here →
  1. a thioester + H2O = a thiol + a carboxylate + H(+)
  2. a thioester + H2O = a thiol + a carboxylate + H(+)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by PNKD, FAHD1

• glycineReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of cysteine and glycine (cytosol to extracellular)

  Catalysed by SUMF1, CBS, SLC3A2, SLC7A5 and 1 morecytosol, extracellular spaceOne of 4 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by SUMF1, TSTD1, GPX1, GPX2 and 1 more

• (R)-S-lactoylglutathioneReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (R)-S-lactoylglutathione = methylglyoxal + glutathione

  Catalysed by SUMF1, TSTD1, GLO1

• S-formylglutathioneReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. S-formylglutathione + H2O = formate + glutathione + H(+)

  Catalysed by SUMF1, TSTD1, ESD

• L-methionineReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of cysteine and methionine (cytosol to extracellular)

  Catalysed by SUMF1, CBS, SLC7A5cytosol, extracellular spaceOne of 6 routes

• N-sulfo-D-glucosamineReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

  Catalysed by SUMF1, SOD1, SGSH

• dehydroepiandrosterone 3-sulfateReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)

  Catalysed by SUMF1, SOD1, STS

• L-tryptophanReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of cysteine and tryptophan (cytosol to extracellular)

  Catalysed by SUMF1, CBS, SLC7A5cytosol, extracellular spaceOne of 4 routes

• L-alanineReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of alanine and cysteine (cytosol to extracellular)

  Catalysed by SUMF1, CBS, SLC7A5cytosol, extracellular spaceOne of 14 routes

• leukotriene C4Reach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. leukotriene C4 = leukotriene A4 + glutathione

  Catalysed by SUMF1, TSTD1, MGST3, GSTM4 and 2 more

• L-asparagineReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of asparagine and cysteine (cytosol to extracellular)

  Catalysed by SUMF1, CBS, SLC7A5cytosol, extracellular spaceOne of 4 routes

• L-phenylalanineReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. transport of cysteine and phenylalanine (cytosol to extracellular)

  Catalysed by SUMF1, CBS, SLC7A5cytosol, extracellular spaceOne of 6 routes

• gamma-L-glutamyl-L-cysteineReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by SUMF1, CBS, GCLC, GCLMcytosolOne of 2 routes

• adenosine 5'-phosphosulfateReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. ATP:sulfate adenylyltransferase

  Catalysed by SUMF1, SOD1, PAPSS1, PAPSS2cytosolOne of 4 routes

• glutathione disulfideReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SUMF1, TSTD1One of 23 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  3. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)

  Catalysed by SUMF1, SQOR, PRODH2

• 5-oxo-L-prolineReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. glutathione = L-cysteinylglycine + 5-oxo-L-proline

  Catalysed by SUMF1, TSTD1, CHAC2, CHAC1

• kynurenateReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O

  Catalysed by SUMF1, MPST, AADAT

• S-sulfanyl-L-cysteineReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by SUMF1, CBS, CARS2cytosol

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by SUMF1, CBS, PPCScytosolOne of 4 routes

• an N-acyl-L-amino acidReach from here →
  1. a thioester + H2O = a thiol + a carboxylate + H(+)
  2. a thioester + H2O = a thiol + a carboxylate + H(+)
  3. an N-acyl-L-amino acid + H2O = an L-alpha-amino acid + a carboxylate

  Catalysed by PNKD, ACY1, PM20D1

• L-prolineReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
  3. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)

  Catalysed by SUMF1, SQOR, PRODH, PRODH2

• estrone 3-sulfateReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. estrone 3-sulfate + H2O = estrone + sulfate + H(+)

  Catalysed by SUMF1, SOD1, STS

• 3-sulfino-L-alanineReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. L-Cysteine:oxygen oxidoreductase

  Catalysed by SUMF1, CBS, CDO1cytosolOne of 2 routes

• L-cysteinylglycineReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. glutathione + H2O = L-cysteinylglycine + L-glutamate

  Catalysed by SUMF1, TSTD1, GGT3P, GGT1 and 3 moreOne of 2 routes

• (5-hydroxyindol-3-yl)acetateReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. Transport of 5-Hydroxyindoleacetate

  Catalysed by SUMF1, SOD1, SLC4A1extracellular space, cytosolOne of 2 routes

• 3-demethylubiquinol-10Reach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate
  3. 3-demethylubiquinol-10 + S-adenosyl-L-methionine = ubiquinol-10 + S-adenosyl-L-homocysteine + H(+)

  Catalysed by SUMF1, SQOR, COQ3

• (9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by SUMF1, TSTD1, GPX1, GPX4

• thio-Mo-molybdopterinReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by SUMF1, CBS, MOCOScytosol

• glycodeoxycholateReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by SUMF1, TSTD1, ABCC4inner side of the membrane, outer side of the membrane

• (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by SUMF1, TSTD1, GPX1, GPX2 and 1 more

• (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by SUMF1, TSTD1, PTGES, MGST3 and 4 more

• (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by SUMF1, TSTD1, GPX1, GPX4

• an S-substituted glutathioneReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by SUMF1, TSTD1, GSTT4, GSTA4 and 21 moreOne of 2 routes

• (13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by SUMF1, TSTD1, GPX1, GSTA1 and 2 more

• taurochenodeoxycholateReach from here →
  1. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by SUMF1, TSTD1, ABCC4inner side of the membrane, outer side of the membrane