3-iodo-L-thyronine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

158 compounds within 3 steps: 3 in 1, 15 in 2, 140 in 3

Three steps

L-valineReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and valine (cytosol to extracellular)
Catalysed by DIO3, MOCOS, SLC7A5extracellular space, cytosolOne of 5 routes
L-arginineReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of arginine and cysteine (cytosol to extracellular)
Catalysed by DIO3, MOCOS, SLC7A6extracellular space, cytosolOne of 7 routes
nitric oxideReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O
Catalysed by DIO3, AIFM1, PYROXD1, SUOX
protein polypeptide chainReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. PROTEIN_BS
Catalysed by DIO3, MOCOScytosol
3'-deoxy-3',4'-didehydro-CTPReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)
Catalysed by DIO3, AIFM1, PYROXD1, RSAD2
(S)-2-hydroxyglutarateReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
Catalysed by DIO3, AIFM1, PYROXD1, L2HGDH
CHEBI:16856Reach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. cystine to cysteine conversion
Catalysed by DIO3, MOCOScytosolOne of 5 routes
CHEBI:16857Reach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and threonine (cytosol to extracellular)
Catalysed by DIO3, MOCOS, SLC7A5extracellular space, cytosolOne of 5 routes
oxalic acidReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. transport of chloride and iodide (cytosol to extracellular)
3. transport of chloride and oxalate (cytosol to extracellular)
Catalysed by DIO3, SLC26A4, SLC26A6extracellular space, cytosol
L-isoleucineReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and isoleucine (cytosol to extracellular)
Catalysed by DIO3, MOCOS, SLC7A5extracellular space, cytosolOne of 6 routes
CHEBI:17203Reach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and proline (cytosol to extracellular)
Catalysed by DIO3, MOCOS, SLC7A5extracellular space, cytosolOne of 5 routes
5'-deoxyadenosineReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
Catalysed by DIO3, AIFM1, PYROXD1, CDK5RAP1One of 4 routes
1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. Lecithin Retinol Acyltransferase
Catalysed by DIO3, RETSAT, LRATcytosol
all-trans-retinyl hexadecanoateReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA
Catalysed by DIO3, RETSAT, DGAT1, PNPLA4 and 3 moreOne of 2 routes
3,3',5-triiodo-L-thyronine sulfateReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
3. aryl sulfotransferase (PAPS)
Catalysed by DIO3, DIO1, DIO2, SULT1A3 and 3 morecytosolOne of 2 routes
L-thyroxine sulfateReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
3. L-thyroxine + 3'-phosphoadenylyl sulfate = L-thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)
Catalysed by DIO3, DIO1, DIO2, SULT1A3 and 2 morecytosol
3,3',5'-triiodo-L-thyronine sulfateReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2
Catalysed by DIO3, AIFM1, PYROXD1, DIO1
3,3'-diiodo-L-thyronineReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
Catalysed by DIO3, AIFM1, PYROXD1, DIO1One of 5 routes
3,3'-diiodo-L-thyronine sulfateReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
Catalysed by DIO3, AIFM1, PYROXD1, DIO1One of 2 routes
CHEBI:17724Reach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
3. dimethylglycine dehydrogenase (formaldehyde)
Catalysed by DIO3, KDM1A, KDM1B, PDPR and 1 morecytosol
glycine betaineReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. choline + A = betaine aldehyde + AH2
3. p-cumic alcohol:NAD+ oxidoreductase
Catalysed by DIO3, CHDH, ALDH7A1cytosolOne of 7 routes
CHEBI:17895Reach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and tyrosine (cytosol to extracellular)
Catalysed by DIO3, MOCOS, SLC7A5extracellular space, cytosolOne of 6 routes
all-trans-retinalReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. retinol: NADP+ oxidoreductase
Catalysed by DIO3, RETSAT, DHRS3, RDH10 and 4 morecytosolOne of 6 routes
CHEBI:18019Reach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and lysine (cytosol to extracellular)
Catalysed by DIO3, MOCOS, SLC7A6extracellular space, cytosolOne of 3 routes
a diacylglycerolReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. a triacylglycerol + all-trans-retinol = an all-trans-retinyl ester + a diacylglycerol
Catalysed by DIO3, RETSAT, PNPLA4, PNPLA2
L-glutamineReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and glutamine (cytosol to extracellular)
Catalysed by DIO3, MOCOS, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 5 routes
CHEBI:18095Reach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. transport of chloride and iodide (cytosol to extracellular)
3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)
Catalysed by DIO3, SLC26A4, CLTRN, SLC6A20extracellular space, cytosol
N-carbamoyl-beta-alanineReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. transport of chloride and iodide (cytosol to extracellular)
3. Transport of 3-Ureidopropionate
Catalysed by DIO3, SLC26A4extracellular space, cytosolOne of 2 routes
3',5'-diiodo-L-thyronineReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
Catalysed by DIO3, AIFM1, PYROXD1
5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. (R)-malate + A = oxaloacetate + AH2
3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
Catalysed by DIO3, D2HGDH, AGXT2
(6R)-5,10-methylenetetrahydrofolic acidReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
3. formaldehyde to 5,10-methylene-THF conversion
Catalysed by DIO3, KDM1A, KDM1Bcytosol
5,6,7,8-tetrahydrofolic acidReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
3. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
Catalysed by DIO3, MTO1, DHFR, DHFR2cytosolOne of 3 routes
S-disulfanyl-L-cysteineReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine
Catalysed by DIO3, MOCOS, CARS2
3-iodothyronamineReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2
Catalysed by DIO3, AIFM1, PYROXD1, DIO1One of 2 routes
3'-iodo-L-thyronineReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2
Catalysed by DIO3, AIFM1, PYROXD1, DIO1 and 1 moreOne of 2 routes
thyronamineReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2
Catalysed by DIO3, AIFM1, PYROXD1
3'-iodothyronamineReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2
Catalysed by DIO3, AIFM1, PYROXD1, DIO1 and 1 moreOne of 2 routes
3,3'-diiodothyronamineReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2
Catalysed by DIO3, AIFM1, PYROXD1, DIO1 and 1 moreOne of 2 routes
3',5'-diiodothyronamineReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2
Catalysed by DIO3, AIFM1, PYROXD1
3,3',5'-triiodothyronamineReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2
Catalysed by DIO3, AIFM1, PYROXD1
CHEBI:240943Reach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. transport of chloride and iodide (cytosol to extracellular)
3. 2-Methylbutyrylglycine Transport, Extracellular
Catalysed by DIO3, SLC26A4, SLC6A5extracellular space, cytosolOne of 2 routes
hypochlorous acidReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. transport of chloride and iodide (cytosol to extracellular)
3. Peroxidase
Catalysed by DIO3, SLC26A4, LPOextracellular space, cytosolOne of 4 routes
potassium atomReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. transport of chloride and iodide (cytosol to extracellular)
3. transport of chloride (cytosol to extracellular)
Catalysed by DIO3, SLC26A4, SLC12A2, SLC12A1extracellular space, cytosolOne of 2 routes
folic acidReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
3. dihydrofolate:NAD+ oxidoreductase
Catalysed by DIO3, MTO1, DHFR, DHFR2cytosolOne of 2 routes
N-acetyl-L-cysteineReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. N-acetylglutamate synthase (N-acetyl-L-cysteine)
Catalysed by DIO3, MOCOS, NAGSmitochondrial matrix
K(+)Reach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
Catalysed by DIO3, MOCOS, SLC1A1inner side of the membrane, outer side of the membraneOne of 2 routes
Cys-tRNA(Cys)Reach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)
Catalysed by DIO3, MOCOS, CARS1cytosol
hydrogenselenideReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
Catalysed by DIO3, AIFM1, PYROXD1, SCLY
hydrogen sulfideReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. L-cysteine hydrogen-sulfide-lyase (deaminating
Catalysed by DIO3, MOCOS, CTHcytosolOne of 2 routes
L-aspartateReach from here →
1. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
2. (R)-malate + A = oxaloacetate + AH2
3. L-Aspartate:2-oxoglutarate aminotransferase
Catalysed by DIO3, D2HGDH, GOT2mitochondrial matrixOne of 5 routes