hydrogen cyanide

Three steps

• (S)-lactoyl-AMPReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + ATP + H(+) = (S)-lactoyl-AMP + diphosphate

  Catalysed by MPST, TST, LDHA, LDHB and 5 morecytosol

• (S)-lactoyl-CoAReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + ATP + CoA = (S)-lactoyl-CoA + AMP + diphosphate

  Catalysed by MPST, TST, LDHA, LDHB and 4 morecytosol

• N-acetylneuraminate 9-phosphateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. pyruvate kinase (dTDP)
  3. N-acetylneuraminate synthase

  Catalysed by MPST, TST, PKM, PKLR and 1 morecytosol

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by MPST, TST, TSTD1, GSTP1mitochondrial matrix

• a quinolReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by MPST, TST, ME2, SDHB and 1 morecytosolOne of 2 routes

• folic acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. Folate Transport by Oats

  Catalysed by MPST, TST, SUOX, SLC22A8 and 1 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• selenomethionineReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. Selenomethionine methanethiol-lyase (deaminating)

  Catalysed by MPST, TST, AGXT2, CTHcytosol

• CHEBI:27760Reach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. Selenocystathionine Lysteine-lyase (deaminating)

  Catalysed by MPST, TST, AGXT2, CTHcytosol

• 3-mercaptolactic acidReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 3-Mercaptolactate:NAD+ oxidoreductase

  Catalysed by MPST, TST, LDHB, LDHC and 2 morecytosol

• 2-oxopentanoateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
  3. 2-oxopentanoate + N(omega),N(omega)-dimethyl-L-arginine = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-2-aminopentanoate

  Catalysed by MPST, TST, AGXT2cytosol

• 17alpha-hydroxypregnenoloneReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space, endoplasmic reticulum

• pyridoxine 5'-phosphateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by MPST, TST, AGXT2, SCLYcytosol, mitochondrial matrix

• a dicarboxylateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by MPST, TST, SUOX, SLC25A35 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-glycoloylneuraminateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. CMP-N-acetylneuraminate monooxygenase (N-acetylneuraminate)

  Catalysed by MPST, TST, NPLcytosol

• a carboxylateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by MPST, TST, FAHD1cytosol

• L-ascorbic acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by MPST, TST, TSTD1, CLIC1 and 2 moremitochondrial matrix

• chlorine(.)Reach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and chloride (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC6A14cytosol, mitochondrial matrix, extracellular spaceOne of 9 routes

• glycocholateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. glycocholate(in) + glutathione(in) + ATP + H2O = glycocholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by MPST, TST, TSTD1, ABCC4mitochondrial matrix, inner side of the membrane, outer side of the membrane

• cholateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by MPST, TST, TSTD1, ABCC4mitochondrial matrix, inner side of the membrane, outer side of the membrane

• hydrogen sulfideReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by MPST, TSTcytosolOne of 4 routes

• D-aspartateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by MPST, TST, SUOX, SLC25A14 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-aspartateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. oxaloacetate + L-alanine = L-aspartate + pyruvate

  Catalysed by MPST, TST, AGXT2cytosol, mitochondrial matrixOne of 10 routes

• oxalateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by MPST, TST, SUOX, SLC25A14 and 4 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• citric acidReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. Pyruvate:carbon-dioxide ligase (ADP-forming)
  3. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)

  Catalysed by MPST, TST, PC, CScytosol, mitochondrial matrixOne of 9 routes

• maleateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by MPST, TST, SUOX, SLC25A14 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• an alcoholReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by MPST, TST, TSTD1, CP and 1 moremitochondrial matrix

• isocitric acidReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. pyruvate kinase (dTDP)
  3. transport of isocitrate and PEP (cytosol to mitochondria)

  Catalysed by MPST, TST, PKM, PKLR and 1 morecytosol, mitochondrial matrixOne of 5 routes

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. Pyruvate:carbon-dioxide ligase (ADP-forming)
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by MPST, TST, PC, GOT2cytosol, mitochondrial matrix

• (2R,3R)-tartrateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by MPST, TST, SUOX, SLC25A14 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by MPST, TST, SUOX, SLC25A14 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by MPST, TST, SUOX, SLC25A14 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by MPST, TST, SUOX, SLC25A14 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• cis-aconitic acidReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. pyruvate kinase (dTDP)
  3. transport of cis-aconitate and PEP (cytosol to mitochondria)

  Catalysed by MPST, TST, PKM, PKLR and 1 morecytosol, mitochondrial matrixOne of 5 routes

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by MPST, TST, TYW1B, TYW1 and 1 morecytosol

• 2-oxohexanoateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
  3. 2-oxohexanoate + N(omega),N(omega)-dimethyl-L-arginine = L-2-aminohexanoate + 5-(3,3-dimethylguanidino)-2-oxopentanoate

  Catalysed by MPST, TST, AGXT2cytosol

• D-cysteineReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by MPST, TST, AGXT2, SLC7A10cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-alpha-aminobutyric acidReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. glutamic-pyruvic transaminase ((S)-2-aminobutanoate)

  Catalysed by MPST, TST, AGXT2, GPTcytosol

• glycochenodeoxycholateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. glycochenodeoxycholate(in) + glutathione(in) + ATP + H2O = glycochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by MPST, TST, TSTD1, ABCC4mitochondrial matrix, inner side of the membrane, outer side of the membrane

• taurocholateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by MPST, TST, TSTD1, ABCC4mitochondrial matrix, inner side of the membrane, outer side of the membrane

• glyoxylateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

  Catalysed by MPST, TST, ME2, CLYBLcytosolOne of 8 routes

• (3S)-3-hydroxy-3-methylglutaryl-CoAReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA

  Catalysed by MPST, TST, HMGCL, HMGCLL1cytosol, mitochondrial matrix

• 13-cis-retinalReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. retinal dehydrogenase (13-cis-retinal)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 6 morecytosol, extracellular space, endoplasmic reticulum

• tert-butanolReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by MPST, TST, TSTD1, CLIC2 and 4 moremitochondrial matrix

• L-ornithineReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and ornithine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A6cytosol, mitochondrial matrix, extracellular spaceOne of 7 routes

• N-(acetyl)-sphing-4-enineReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• gamma-Glu-AlaReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by MPST, TST, AGXT2, GGT1 and 5 morecytosol, mitochondrial matrix, extracellular space

• acetoacetyl-CoAReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate

  Catalysed by MPST, TST, AACScytosol, mitochondrial matrixOne of 2 routes

• glycineReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-Alanine:glyoxylate aminotransferase

  Catalysed by MPST, TST, AGXT2, AGXTcytosol, mitochondrial matrixOne of 14 routes

• (S)-malyl-CoAReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. (S)-malate + ATP + CoA = (S)-malyl-CoA + ADP + phosphate

  Catalysed by MPST, TST, ME2, SUCLG1 and 1 morecytosol

• (R)-methylmalonyl-CoAReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by MPST, TST, AGXT2, ALDH6A1cytosol, mitochondrial matrix