agmatine

Three steps

• L-isoleucineReach from here →
  1. Agmatine amidinohydrolase
  2. Putrescine Export via Putrescine/Arginine Antiporter
  3. transport of arginine and isoleucine (cytosol to extracellular)

  Catalysed by AGMAT, SLC3A2, SLC7A7, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• CHEBI:17203Reach from here →
  1. Agmatine amidinohydrolase
  2. Putrescine Export via Putrescine/Arginine Antiporter
  3. transport of arginine and proline (cytosol to extracellular)

  Catalysed by AGMAT, SLC3A2, SLC7A7, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• CHEBI:17208Reach from here →
  1. Agmatine amidinohydrolase
  2. Peroxidase
  3. ascorbate to monodehydroascorbate conversion

  Catalysed by AGMAT, MPOmitochondrial matrix, nucleus, cytosol

• L-glutamic 5-semialdehydeReach from here →
  1. Agmatine amidinohydrolase
  2. L-ornithine + H(+) = putrescine + CO2
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by AGMAT, ODC1, OATmitochondrial matrix

• anilineReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by AGMAT, SAT1, SAT2, NAT2 and 1 moremitochondrial matrix, cytosol

• CHEBI:17312Reach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by AGMAT, SAT1, SAT2mitochondrial matrix, cytosolOne of 2 routes

• L-cysteineReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by AGMAT, SAT1, SAT2, NAGSmitochondrial matrix, cytosolOne of 8 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by AGMAT, SAT1, SAT2, HADHA and 2 moremitochondrial matrix, cytosol

• xanthineReach from here →
  1. Agmatine amidinohydrolase
  2. Peroxidase
  3. xanthine + NAD(+) + H2O = urate + NADH + H(+)

  Catalysed by AGMAT, MPO, XDHmitochondrial matrix, nucleusOne of 2 routes

• CHEBI:17895Reach from here →
  1. Agmatine amidinohydrolase
  2. Putrescine Export via Putrescine/Arginine Antiporter
  3. transport of arginine and tyrosine (cytosol to extracellular)

  Catalysed by AGMAT, SLC3A2, SLC7A7, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• CHEBI:17927Reach from here →
  1. Agmatine amidinohydrolase
  2. S-adenosylmethioninamine:putrescine 3-aminopropyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by AGMAT, SRM, SAT1, SAT2mitochondrial matrix, cytosolOne of 4 routes

• CHEBI:18019Reach from here →
  1. Agmatine amidinohydrolase
  2. Putrescine Export via Putrescine/Arginine Antiporter
  3. transport of arginine and lysine (cytosol to extracellular)

  Catalysed by AGMAT, SLC3A2, SLC7A7, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 8 routes

• L-glutamineReach from here →
  1. Agmatine amidinohydrolase
  2. Putrescine Export via Putrescine/Arginine Antiporter
  3. transport of arginine and glutamine (cytosol to extracellular)

  Catalysed by AGMAT, SLC3A2, SLC7A7, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 7 routes

• 5-hydroxyisourateReach from here →
  1. Agmatine amidinohydrolase
  2. Peroxidase
  3. urate:oxygen oxidoreductase

  Catalysed by AGMAT, MPOmitochondrial matrix, nucleus, cytosol

• N-(4-aminobutyl)-3-aminopropanalReach from here →
  1. Agmatine amidinohydrolase
  2. S-adenosylmethioninamine:putrescine 3-aminopropyltransferase
  3. primary-amine oxidase (spermidine)

  Catalysed by AGMAT, SRM, AOC2, AOC1 and 1 moremitochondrial matrix, cytosolOne of 3 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by AGMAT, SAT1, SAT2, HADHA and 2 moremitochondrial matrix, cytosolOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by AGMAT, SAT1, SAT2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by AGMAT, SAT1, SAT2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by AGMAT, SAT1, SAT2, HADHA and 2 moremitochondrial matrix, cytosolOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by AGMAT, SAT1, SAT2, HADHA and 2 moremitochondrial matrix, cytosol

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by AGMAT, SAT1, SAT2, ECHS1 and 2 moremitochondrial matrix, cytosolOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by AGMAT, SAT1, SAT2, ECHS1 and 2 moremitochondrial matrix, cytosolOne of 2 routes

• CHEBI:27540Reach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by AGMAT, SAT1, SAT2, ACSM4 and 5 moremitochondrial matrix, cytosolOne of 6 routes

• elaidic acidReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by AGMAT, SAT1, SAT2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes

• CHEBI:28701Reach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by AGMAT, SAT1, SAT2, ACAA1 and 2 moremitochondrial matrix, cytosol, peroxisomeOne of 7 routes

• a dicarboxylateReach from here →
  1. Agmatine amidinohydrolase
  2. Peroxidase
  3. urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)

  Catalysed by AGMAT, MPO, SLC22A6mitochondrial matrix, nucleus, inner side of the membrane, outer side of the membraneOne of 2 routes

• chlorine(.)Reach from here →
  1. Agmatine amidinohydrolase
  2. Putrescine Export via Putrescine/Arginine Antiporter
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by AGMAT, SLC3A2, SLC7A7, SLC6A14mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• acetateReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by AGMAT, SAT1, SAT2, HDAC10mitochondrial matrix, cytosol

• 3-acetamidopropanalReach from here →
  1. Agmatine amidinohydrolase
  2. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2
  3. N(1)-acetylspermidine + O2 + H2O = 3-acetamidopropanal + putrescine + H2O2

  Catalysed by AGMAT, PAOXmitochondrial matrix

• glutarateReach from here →
  1. Agmatine amidinohydrolase
  2. Peroxidase
  3. urate(in) + glutarate(out) = urate(out) + glutarate(in)

  Catalysed by AGMAT, MPO, SLC22A8mitochondrial matrix, nucleus, inner side of the membrane, outer side of the membraneOne of 2 routes

• nicotinateReach from here →
  1. Agmatine amidinohydrolase
  2. Peroxidase
  3. nicotinate(in) + urate(out) = nicotinate(out) + urate(in)

  Catalysed by AGMAT, MPO, SLC22A12, SLC22A13mitochondrial matrix, nucleus, inner side of the membrane, outer side of the membrane

• L-lysineReach from here →
  1. Agmatine amidinohydrolase
  2. Putrescine Export via Putrescine/Arginine Antiporter
  3. L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)

  Catalysed by AGMAT, SLC3A2, SLC7A7, SLC7A9 and 2 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• D-lysineReach from here →
  1. Agmatine amidinohydrolase
  2. L-ornithine + H(+) = putrescine + CO2
  3. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by AGMAT, ODC1, SLC25A2mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-arginineReach from here →
  1. Agmatine amidinohydrolase
  2. L-ornithine + H(+) = putrescine + CO2
  3. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by AGMAT, ODC1, SLC25A2mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S)-lactic acidReach from here →
  1. Agmatine amidinohydrolase
  2. Peroxidase
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by AGMAT, MPO, SLC22A12mitochondrial matrix, nucleus, extracellular space, cytosol

• spermineReach from here →
  1. Agmatine amidinohydrolase
  2. S-adenosylmethioninamine:putrescine 3-aminopropyltransferase
  3. S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = spermine + S-methyl-5'-thioadenosine + H(+)

  Catalysed by AGMAT, SRM, SMSmitochondrial matrix, cytosolOne of 2 routes

• taurineReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by AGMAT, SAT1, SAT2, BAATmitochondrial matrix, cytosolOne of 2 routes

• glycineReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by AGMAT, SAT1, SAT2, GLYAT and 2 moremitochondrial matrix, cytosolOne of 16 routes

• (R)-methylmalonyl-CoAReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by AGMAT, SAT1, SAT2, ALDH6A1mitochondrial matrix, cytosolOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by AGMAT, SAT1, SAT2mitochondrial matrix, cytosol

• 3'-dephospho-CoAReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by AGMAT, SAT1, SAT2, ACP2mitochondrial matrix, cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by AGMAT, SAT1, SAT2mitochondrial matrix, cytosolOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by AGMAT, SAT1, SAT2, ACAA1 and 1 moremitochondrial matrix, cytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by AGMAT, SAT1, SAT2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by AGMAT, SAT1, SAT2, ACSM4 and 5 moremitochondrial matrix, cytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by AGMAT, SAT1, SAT2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Production of Glutaryl Carnitine

  Catalysed by AGMAT, SAT1, SAT2, CPT1A and 2 moremitochondrial matrix, cytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by AGMAT, SAT1, SAT2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by AGMAT, SAT1, SAT2, SUCLG1 and 2 moremitochondrial matrix, cytosolOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. Agmatine amidinohydrolase
  2. acetyl-CoA:putrescine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by AGMAT, SAT1, SAT2, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 13 routes