D-aspartic acid

Three steps

• iodideReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosol

• cis-aconitateReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. cis-aconitate(in) + citrate(out) = cis-aconitate(out) + citrate(in)

  Catalysed by DDO, CS, SLC25A1peroxisome, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-valineReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosolOne of 4 routes

• L-arginineReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosolOne of 2 routes

• CHEBI:16497Reach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. GTP:oxaloacetate carboxy-lyase (adding GTP
  3. dGTP:pyruvate 2-O-phosphotransferase

  Catalysed by DDO, PCK1, PKM, PKLRperoxisome, cytosol

• protein polypeptide chainReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of aspartate (cytosol to extracellular)
  3. PROTEIN_BS

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 1 moreextracellular space, cytosol

• (S)-lactateReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. Oxaloacetate Decarboxylase
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by DDO, FAHD1, LDHA, LDHB and 3 moreperoxisome, cytosol

• 2-oxobutanoateReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. Oxaloacetate Decarboxylase
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by DDO, FAHD1, AGXT2peroxisome, cytosolOne of 2 routes

• 2-oxoglutaramateReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. Oxaloacetate Decarboxylase
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by DDO, FAHD1, KYAT1peroxisome, cytosolOne of 2 routes

• 3-fumarylpyruvateReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. Oxaloacetate Decarboxylase
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by DDO, FAHD1peroxisome, cytosol

• CHEBI:16856Reach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of GSH and serotonin (cytosol to extracellular)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosolOne of 2 routes

• CHEBI:16857Reach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosol

• glyoxylic acidReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. D-aspartate:2-oxoglutarate aminotransferase
  3. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)

  Catalysed by DDO, GOT2, HOGA1peroxisome, mitochondrial matrix

• N-acetyl-L-aspartateReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of aspartate (cytosol to extracellular)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 2 routes

• oxalic acidReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosolOne of 4 routes

• (R)-3-hydroxybutyric acidReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. Oxaloacetate Decarboxylase
  3. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

  Catalysed by DDO, FAHD1, SLC16A4, SLC16A5 and 4 moreperoxisome, cytosol, extracellular spaceOne of 2 routes

• 3-hydroxypyruvateReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. Oxaloacetate Decarboxylase
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by DDO, FAHD1, AGXTperoxisome, cytosol

• L-isoleucineReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosolOne of 2 routes

• CHEBI:17203Reach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 5 moreextracellular space, cytosolOne of 3 routes

• anilineReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by DDO, CS, NAT2, NAT1peroxisome, mitochondrial matrix, cytosol

• aceneuramateReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. Oxaloacetate Decarboxylase
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by DDO, FAHD1, NPLperoxisome, cytosol

• CHEBI:17312Reach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by DDO, CSperoxisome, mitochondrial matrix, cytosolOne of 2 routes

• 5'-deoxyadenosineReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. Oxaloacetate Decarboxylase
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by DDO, FAHD1, TYW1B, TYW1peroxisome, cytosol

• sulfiteReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. transport of malate and OAA (cytosol to mitochondria)
  3. transport of malate and sulfite (cytosol to mitochondria)

  Catalysed by DDO, SLC25A10peroxisome, mitochondrial matrix, cytosolOne of 2 routes

• enol-oxaloacetateReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. transport of malate and OAA (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by DDO, SDHB, SDHAperoxisome, mitochondrial matrix, cytosol

• L-cysteineReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of chloride and cysteine (cytosol to extracellular)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosolOne of 3 routes

• N-acetylserotoninReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. acetyl-CoA:aralkylamine N-acetyltransferase

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreextracellular space, cytosol

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by DDO, CS, HADHA, ACADVL and 1 moreperoxisome, mitochondrial matrix

• glycine betaineReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of betaine and chloride (cytosol to extracellular)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosolOne of 3 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreextracellular space, cytosol

• CHEBI:17895Reach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosolOne of 2 routes

• CHEBI:17927Reach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by DDO, CSperoxisome, mitochondrial matrix, cytosol

• fumaric acidReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. transport of malate and OAA (cytosol to mitochondria)
  3. (S)-malate hydro-lyase (fumarate-forming)

  Catalysed by DDO, FHperoxisome, mitochondrial matrix, cytosolOne of 5 routes

• CHEBI:18019Reach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosol

• L-glutamineReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosolOne of 3 routes

• dTDPReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. Oxaloacetate Decarboxylase
  3. pyruvate kinase (dTDP)

  Catalysed by DDO, FAHD1, PKM, PKLRperoxisome, cytosol

• dTTPReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. GTP:oxaloacetate carboxy-lyase (adding GTP
  3. pyruvate kinase (dTDP)

  Catalysed by DDO, PCK1, PKM, PKLRperoxisome, cytosol

• CHEBI:18095Reach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 5 moreextracellular space, cytosol

• N-carbamoyl-beta-alanineReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 3 moreextracellular space, cytosolOne of 2 routes

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. Oxaloacetate Decarboxylase
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by DDO, FAHD1, AGXT2peroxisome, cytosol

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. Oxaloacetate Decarboxylase
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by DDO, FAHD1, AGXT2peroxisome, cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by DDO, CS, HADHA, ACAA2 and 1 moreperoxisome, mitochondrial matrixOne of 2 routes

• N-acetylneuraminate 9-phosphateReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. GTP:oxaloacetate carboxy-lyase (adding GTP
  3. N-acetylneuraminate synthase

  Catalysed by DDO, PCK1, NANSperoxisome, cytosolOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moreperoxisome, mitochondrial matrix, cytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by DDO, CS, SLC27A2, ACSL4 and 6 moreperoxisome, mitochondrial matrix, cytosolOne of 8 routes

• serotonin O-sulfateReach from here →
  1. transport of D-aspartate (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. serotonin + 3'-phosphoadenylyl sulfate = serotonin O-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLC1A7, SLC1A3, SLC1A2, SLC1A1 and 4 moreextracellular space, cytosol

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by DDO, CS, HADHA, ACADVL and 1 moreperoxisome, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by DDO, CS, HADHA, ACADVL and 1 moreperoxisome, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by DDO, CS, ECHS1, ACAA2 and 1 moreperoxisome, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. D-Aspartate:oxygen oxidoreductase (deaminating)
  2. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by DDO, CS, ECHS1, ACAA2 and 1 moreperoxisome, mitochondrial matrixOne of 2 routes