L-citrulline

1. transport of citrulline and cysteine (cytosol to extracellular)
2. L-Cysteine:2-oxoglutarate aminotransferase

Catalysed by SLC7A6, GOT2, GOT1extracellular space, cytosolOne of 3 routes

1. transport of arginine and citrulline (cytosol to extracellular)
2. L-Arginine:glycine amidinotransferase

Catalysed by SLC7A5, SLC7A6, GATMextracellular space, cytosolOne of 4 routes

1. transport of alanine and citrulline (cytosol to extracellular)
2. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

Catalysed by SLC7A6, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

1. transport of citrulline and tyrosine (cytosol to extracellular)
2. L-Tyrosine,L-dopa:oxygen oxidoreductase

Catalysed by SLC7A6, TYRextracellular space, cytosol

1. transport of citrulline and glycine (cytosol to extracellular)
2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

Catalysed by SLC7A9, SLC3A1, SLC7A6, GSSextracellular space, cytosol

1. transport of alanine and citrulline (cytosol to extracellular)
2. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

Catalysed by SLC7A6, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 8 routes

1. transport of citrulline and lysine (cytosol to extracellular)
2. N6-(L-1,3-Dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-lysine-forming)

Catalysed by SLC7A5, SLC7A6, AASSextracellular space, cytosol, mitochondrial matrix

1. transport of alanine and citrulline (cytosol to extracellular)
2. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

Catalysed by SLC7A6, KYNUextracellular space, cytosolOne of 5 routes

1. transport of alanine and citrulline (cytosol to extracellular)
2. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

Catalysed by SLC7A6, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

1. transport of citrulline and glycine (cytosol to extracellular)
2. leukotriene C4 hydrolysis

Catalysed by SLC7A9, SLC3A1, SLC7A6extracellular space, cytosol

1. transport of arginine and citrulline (cytosol to extracellular)
2. taurine + L-arginine = taurocyamine + L-ornithine

Catalysed by SLC7A5, SLC7A6, GATMextracellular space, cytosol

1. Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15
2. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate

Catalysed by SLC7A9, OATextracellular space, cytosol

1. transport of alanine and citrulline (cytosol to extracellular)
2. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

Catalysed by SLC7A6, KYNUextracellular space, cytosol

1. transport of citrulline and cysteine (cytosol to extracellular)
2. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

Catalysed by SLC7A6, GCLC, GCLMextracellular space, cytosolOne of 2 routes

1. transport of citrulline and lysine (cytosol to extracellular)
2. L-lysine:oxygen 2-oxidoreductase (deaminating)

Catalysed by SLC7A5, SLC7A6extracellular space, cytosol, peroxisome

1. transport of citrulline and methionine (cytosol to extracellular)
2. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

Catalysed by SLC7A6, BHMT2extracellular space, cytosol

1. transport of citrulline and methionine (cytosol to extracellular)
2. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

Catalysed by SLC7A6, BHMT2extracellular space, cytosol

1. transport of citrulline and phenylalanine (cytosol to extracellular)
2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

Catalysed by SLC7A6, PAHextracellular space, cytosolOne of 2 routes

1. Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15
2. N(omega),N(omega)-dimethyl-L-arginine(in) + L-ornithine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-ornithine(in)

Catalysed by SLC7A9, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

1. transport of alanine and citrulline (cytosol to extracellular)
2. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

Catalysed by SLC7A6, SLC1A4extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

1. transport of citrulline and histidine (cytosol to extracellular)
2. L-histidine carboxy-lyase (histamine-forming)

Catalysed by SLC7A5, SLC7A6, HDCextracellular space, cytosol

1. transport of arginine and citrulline (cytosol to extracellular)
2. L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)

Catalysed by SLC7A5, SLC7A6, IL4I1extracellular space, cytosol

1. transport of citrulline and cysteine (cytosol to extracellular)
2. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

Catalysed by SLC7A6, CARS2extracellular space, cytosol

1. transport of citrulline and tryptophan (cytosol to extracellular)
2. L-tryptophan + O2 = N-formyl-L-kynurenine

Catalysed by SLC7A9, SLC3A1, SLC7A6, IDO1 and 2 moreextracellular space, cytosol

1. transport of citrulline and glutamine (cytosol to extracellular)
2. phosphoribosyl pyrophosphate amidotransferase (glutamine)

Catalysed by SLC7A6, PPATextracellular space, cytosolOne of 2 routes

1. transport of citrulline and glutamine (cytosol to extracellular)
2. D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate

Catalysed by SLC7A6, GFPT2, GFPT1extracellular space, cytosol

1. transport of citrulline and methionine (cytosol to extracellular)
2. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

Catalysed by SLC7A6, MSRAextracellular space, cytosol

1. transport of citrulline and methionine (cytosol to extracellular)
2. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

Catalysed by SLC7A6, MSRB3, MSRB1, MSRB2extracellular space, cytosol

1. Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15
2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

Catalysed by SLC7A9, AGXT2extracellular space, cytosolOne of 2 routes

1. transport of citrulline and glycine (cytosol to extracellular)
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

Catalysed by SLC7A9, SLC3A1, SLC7A6, GLYATL2extracellular space, cytosolOne of 2 routes

1. transport of citrulline and cysteine (cytosol to extracellular)
2. (R)-4'-phosphopantothenate:L-cysteine ligase

Catalysed by SLC7A6, PPCSextracellular space, cytosolOne of 4 routes

1. transport of citrulline and tyrosine (cytosol to extracellular)
2. thyroid peroxidase (iodine)

Catalysed by SLC7A6, TPOextracellular space, cytosolOne of 2 routes

1. transport of alanine and citrulline (cytosol to extracellular)
2. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

Catalysed by SLC7A6, SLC1A4extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

1. transport of citrulline and glycine (cytosol to extracellular)
2. Hippurate (Benzoylglycinate) Formation

Catalysed by SLC7A9, SLC3A1, SLC7A6extracellular space, cytosol, mitochondrial matrixOne of 2 routes

1. transport of citrulline and cysteine (cytosol to extracellular)
2. L-Cysteine:oxygen oxidoreductase

Catalysed by SLC7A6, CDO1extracellular space, cytosolOne of 2 routes

1. transport of alanine and citrulline (cytosol to extracellular)
2. gamma-glutamyltransferase (alanine)

Catalysed by SLC7A6, GGTLC3, GGT1, GGT5 and 3 moreextracellular space, cytosolOne of 2 routes

1. transport of arginine and citrulline (cytosol to extracellular)
2. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

Catalysed by SLC7A5, SLC7A6, NOS3, NOS1 and 1 moreextracellular space, cytosol

1. transport of alanine and citrulline (cytosol to extracellular)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by SLC7A6, MOCOSextracellular space, cytosol

1. transport of alanine and citrulline (cytosol to extracellular)
2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

Catalysed by SLC7A6, AGXT2extracellular space, cytosolOne of 2 routes

1. transport of citrulline and cysteine (cytosol to extracellular)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by SLC7A6, MOCOSextracellular space, cytosol

1. transport of citrulline and glycine (cytosol to extracellular)
2. Glycodeoxycholate amidohydrolase

Catalysed by SLC7A9, SLC3A1, SLC7A6extracellular space, cytosolOne of 2 routes

1. transport of citrulline and glycine (cytosol to extracellular)
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

Catalysed by SLC7A9, SLC3A1, SLC7A6, GLYATL2extracellular space, cytosol

1. transport of citrulline and glycine (cytosol to extracellular)
2. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

Catalysed by SLC7A9, SLC3A1, SLC7A6, BAATextracellular space, cytosol

1. transport of citrulline and glycine (cytosol to extracellular)
2. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

Catalysed by SLC7A9, SLC3A1, SLC7A6, BAATextracellular space, cytosol

1. transport of citrulline and glycine (cytosol to extracellular)
2. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

Catalysed by SLC7A9, SLC3A1, SLC7A6, BAATextracellular space, cytosol

1. transport of citrulline and glutamine (cytosol to extracellular)
2. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

Catalysed by SLC7A6, GLYATL1B, GLYATL1extracellular space, cytosol

1. transport of citrulline and tyrosine (cytosol to extracellular)
2. L-tyrosine:2-oxoglutarate aminotransferase
3. (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) = 3-(4-hydroxyphenyl)pyruvate + NADH + H(+)

Catalysed by SLC7A6, GOT2, GOT1, TAT and 1 moreextracellular space, cytosol

1. transport of citrulline and lysine (cytosol to extracellular)
2. transport of chloride and lysine (cytosol to extracellular)
3. Carnitine Transport by Atb0