L-citrulline

Two steps

• S-disulfanyl-L-cysteineReach from here →
  1. transport of citrulline and cysteine (cytosol to extracellular)
  2. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by SLC7A6, CARS2extracellular space, cytosol

• CHEBI:240943Reach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SLC7A9, SLC3A1, SLC7A6, GLYAT and 2 moreextracellular space, cytosol, mitochondrial matrix

• phenylacetylglycineReach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by SLC7A9, SLC3A1, SLC7A6, GLYATextracellular space, cytosolOne of 3 routes

• 5-hydroxytryptophanReach from here →
  1. transport of citrulline and tryptophan (cytosol to extracellular)
  2. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by SLC7A9, SLC3A1, SLC7A6, TPH1 and 1 moreextracellular space, cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. LTD4 hydrolysis

  Catalysed by SLC7A9, SLC3A1, SLC7A6extracellular space, cytosol

• pyridoxine 5'-phosphateReach from here →
  1. transport of alanine and citrulline (cytosol to extracellular)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC7A6, SCLYextracellular space, cytosol

• N-acetyl-L-cysteineReach from here →
  1. transport of citrulline and cysteine (cytosol to extracellular)
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SLC7A6, NAGSextracellular space, cytosol, mitochondrial matrix

• K(+)Reach from here →
  1. transport of citrulline and cysteine (cytosol to extracellular)
  2. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC7A6, SLC1A1extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• Cys-tRNA(Cys)Reach from here →
  1. transport of citrulline and cysteine (cytosol to extracellular)
  2. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by SLC7A6, CARS1extracellular space, cytosol

• Phe-tRNA(Phe)Reach from here →
  1. transport of citrulline and phenylalanine (cytosol to extracellular)
  2. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by SLC7A6, FARSB, FARSAextracellular space, cytosol

• Gly-tRNA(Gly)Reach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by SLC7A9, SLC3A1, SLC7A6, GARS1extracellular space, cytosol

• Trp-tRNA(Trp)Reach from here →
  1. transport of citrulline and tryptophan (cytosol to extracellular)
  2. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by SLC7A9, SLC3A1, SLC7A6, WARS1extracellular space, cytosol

• Ile-tRNA(Ile)Reach from here →
  1. transport of citrulline and isoleucine (cytosol to extracellular)
  2. L-Isoleucine:tRNA(Ile) ligase (AMP-forming)

  Catalysed by SLC7A6, IARS1extracellular space, cytosol

• Gln-tRNA(Gln)Reach from here →
  1. transport of citrulline and glutamine (cytosol to extracellular)
  2. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by SLC7A6, QARS1extracellular space, cytosol

• Asn-tRNA(Asn)Reach from here →
  1. transport of asparagine and citrulline (cytosol to extracellular)
  2. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by SLC7A9, SLC3A1, SLC7A6, NARS1extracellular space, cytosol

• chlorine(.)Reach from here →
  1. transport of citrulline and lysine (cytosol to extracellular)
  2. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by SLC7A5, SLC7A6, SLC6A14extracellular space, cytosolOne of 31 routes

• glycocholateReach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC7A9, SLC3A1, SLC7A6, BAATextracellular space, cytosol, peroxisomeOne of 3 routes

• hydrogen sulfideReach from here →
  1. transport of citrulline and cysteine (cytosol to extracellular)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by SLC7A6, CTHextracellular space, cytosolOne of 2 routes

• L-aspartateReach from here →
  1. L-Citrulline:L-aspartate ligase (AMP-forming)
  2. L-citrulline + L-aspartate + ATP = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)

  Catalysed by ASS1cytosolOne of 19 routes

• CHEBI:30249Reach from here →
  1. transport of citrulline and tryptophan (cytosol to extracellular)
  2. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by SLC7A9, SLC3A1, SLC7A6, IDO1 and 2 moreextracellular space, cytosol

• L-lysineReach from here →
  1. Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15
  2. L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)

  Catalysed by SLC7A9, SLC25A2, SLC25A15extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 5 routes

• D-lysineReach from here →
  1. Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15
  2. D-lysine(in) + L-ornithine(out) = D-lysine(out) + L-ornithine(in)

  Catalysed by SLC7A9, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• putrescineReach from here →
  1. Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15
  2. L-ornithine carboxy-lyase (putrescine-forming)

  Catalysed by SLC7A9, ODC1extracellular space, cytosolOne of 4 routes

• D-arginineReach from here →
  1. Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15
  2. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)

  Catalysed by SLC7A9, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-carbamoyl-L-aspartateReach from here →
  1. Carbamoyl-phosphate:L-ornithine carbamoyltransferase
  2. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by OTC, CADmitochondrial matrix

• 4-methylthio-2-oxobutanoic acidReach from here →
  1. transport of citrulline and methionine (cytosol to extracellular)
  2. L-Methionine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC7A6, IL4I1extracellular space, cytosol

• di-mu-sulfido-diiron(2+)Reach from here →
  1. transport of citrulline and cysteine (cytosol to extracellular)
  2. De novo synthesis of 2Fe2S

  Catalysed by SLC7A6, NDUFAB1, FDXR, FXN and 4 moreextracellular space, cytosol, mitochondrial matrix

• (S)-3-methyl-2-oxopentanoateReach from here →
  1. transport of citrulline and isoleucine (cytosol to extracellular)
  2. L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate

  Catalysed by SLC7A6, BCAT2, BCAT1extracellular space, cytosol

• D-cysteineReach from here →
  1. transport of alanine and citrulline (cytosol to extracellular)
  2. D-cysteine(out) + L-alanine(in) = D-cysteine(in) + L-alanine(out)

  Catalysed by SLC7A6, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-serineReach from here →
  1. transport of alanine and citrulline (cytosol to extracellular)
  2. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)

  Catalysed by SLC7A6, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 10 routes

• 5-aminolevulinateReach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by SLC7A9, SLC3A1, SLC7A6, ALAS1 and 1 moreextracellular space, cytosol

• 3-methyl-2-oxovaleric acidReach from here →
  1. transport of citrulline and isoleucine (cytosol to extracellular)
  2. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by SLC7A6, BCAT1extracellular space, cytosolOne of 2 routes

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. transport of citrulline and tyrosine (cytosol to extracellular)
  2. L-tyrosine:2-oxoglutarate aminotransferase

  Catalysed by SLC7A6, GOT2, GOT1, TATextracellular space, cytosolOne of 3 routes

• glycochenodeoxycholateReach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by SLC7A9, SLC3A1, SLC7A6, BAATextracellular space, cytosol

• glycochenodeoxycholic acidReach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by SLC7A9, SLC3A1, SLC7A6, BAATextracellular space, cytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by SLC7A9, SLC3A1, SLC7A6, AADATextracellular space, cytosolOne of 11 routes

• glycolithocholic acidReach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by SLC7A9, SLC3A1, SLC7A6, BAATextracellular space, cytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by SLC7A9, SLC3A1, SLC7A6, GCATextracellular space, cytosol, mitochondrial matrix

• D-glucopyranose 6-phosphateReach from here →
  1. Carbamoyl-phosphate:L-ornithine carbamoyltransferase
  2. glucose-6-phosphatase (carbamoyl-phosphate)

  Catalysed by OTC, G6PC2mitochondrial matrix, endoplasmic reticulum

• gamma-Glu-AlaReach from here →
  1. transport of alanine and citrulline (cytosol to extracellular)
  2. gamma-glutamyltransferase (alanine)

  Catalysed by SLC7A6, GGT1, GGT5, GGTLC2 and 3 moreextracellular space, cytosol

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by SLC7A9, SLC3A1, SLC7A6, GLDC and 1 moreextracellular space, cytosol, mitochondrial matrix

• D-alanineReach from here →
  1. transport of alanine and citrulline (cytosol to extracellular)
  2. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by SLC7A6, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• sarcosineReach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by SLC7A9, SLC3A1, SLC7A6, PIPOXextracellular space, cytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by SLC7A9, SLC3A1, SLC7A6, SHMT1 and 1 moreextracellular space, cytosol

• 4-guanidinobutanoateReach from here →
  1. transport of arginine and citrulline (cytosol to extracellular)
  2. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine

  Catalysed by SLC7A5, SLC7A6, GATMextracellular space, cytosol

• L-dopaReach from here →
  1. transport of citrulline and phenylalanine (cytosol to extracellular)
  2. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)

  Catalysed by SLC7A6, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-guanidinopropanoateReach from here →
  1. transport of arginine and citrulline (cytosol to extracellular)
  2. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine

  Catalysed by SLC7A5, SLC7A6, GATMextracellular space, cytosol

• L-histidineReach from here →
  1. Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15
  2. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)

  Catalysed by SLC7A9, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 7 routes

• D-ornithineReach from here →
  1. Amino Acid-Polyamine-Organocation (Apc) Tcdb:2.A.3.8.15
  2. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)

  Catalysed by SLC7A9, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• an N-acylglycineReach from here →
  1. transport of citrulline and glycine (cytosol to extracellular)
  2. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by SLC7A9, SLC3A1, SLC7A6, GLYATL3 and 2 moreextracellular space, cytosol