a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

98 compounds within 3 steps: 4 in 1, 36 in 2, 58 in 3

Three steps

a globoside Gb4Cer (d18:1(4E))Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a globoside Gb3Cer (d18:1(4E)) + UDP + H(+)
3. globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase (globotriaosylceramide)
Catalysed by C1GALT1, A4GALTcytosolOne of 5 routes
D-glucosyl-N-acylsphingosineReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP + H(+)
3. beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase
Catalysed by C1GALT1, B4GALT5, B4GALT6, LCT and 3 morelysosome
a ganglioside beta-D-GlcNAc-(1->6)-GA1Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. UDP-N-acetyl-alpha-D-glucosamine(out) + UDP-alpha-D-galactose(in) = UDP-N-acetyl-alpha-D-glucosamine(in) + UDP-alpha-D-galactose(out)
3. a ganglioside GA1 + UDP-N-acetyl-alpha-D-glucosamine = a ganglioside beta-D-GlcNAc-(1->6)-GA1 + UDP + H(+)
Catalysed by C1GALT1, SLC35A2, GCNT1inner side of the membrane, outer side of the membrane
cholesteryl 3-beta-D-galactosideReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)
3. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + an N-acylsphing-4-enine
Catalysed by C1GALT1, UGT8, GBA1, GBA2
a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enineReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose
3. an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)
Catalysed by C1GALT1, GALT, UGCG
a lysoGb3(d18:1(4E))Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a globoside Gb3Cer (d18:1(4E)) + UDP + H(+)
3. a globoside Gb3Cer (d18:1(4E)) + H2O = a lysoGb3(d18:1(4E)) + a fatty acid
Catalysed by C1GALT1, A4GALT, ASAH1
a lysoGb3Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose = a globoside Gb3Cer + UDP + H(+)
3. a globoside Gb3Cer + H2O = a lysoGb3 + a fatty acid
Catalysed by C1GALT1, A4GALT, ASAH1
an N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-galactosyl derivativeReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. UDP-N-acetyl-alpha-D-glucosamine(out) + UDP-alpha-D-galactose(in) = UDP-N-acetyl-alpha-D-glucosamine(in) + UDP-alpha-D-galactose(out)
3. a beta-D-galactoside + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-galactosyl derivative + UDP + H(+)
Catalysed by C1GALT1, SLC35A2, A4GNTinner side of the membrane, outer side of the membrane
beta-D-galactoseReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. D-glucose + UDP-alpha-D-galactose = lactose + UDP + H(+)
3. lactose + H2O = beta-D-galactose + D-glucose
Catalysed by C1GALT1, B4GALT2, B4GALT1, LCT
a ganglioside GA2 (d18:1(4E))Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP + H(+)
3. beta-1,4-N-acetyl-galactosaminyltransferase (LacCer pool)
Catalysed by C1GALT1, B4GALT5, B4GALT6, B4GALNT1cytosolOne of 4 routes
alpha-D-galactoseReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a globoside Gb3Cer (d18:1(4E)) + UDP + H(+)
3. galactosidase alpha (globotriaosylceramide)
Catalysed by C1GALT1, A4GALT, GLAcytosolOne of 9 routes
(2S)-naringenin 7-O-beta-D-glucosideReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose
3. (2S)-naringenin + UDP-alpha-D-glucose = (2S)-naringenin 7-O-beta-D-glucoside + UDP + H(+)
Catalysed by C1GALT1, GALT, UGT3A2
a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E))Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside nLc4Cer(d18:1(4E)) + UDP + H(+)
3. a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)
Catalysed by C1GALT1, B4GALT3, B4GALT4, B4GALT1 and 2 more
alpha-L-fucosyl-(1->2)- beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enineReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E)) + UDP + H(+)
3. type 1 galactoside alpha-(1,2)-fucosyltransferase (GDP-L-fucose)
Catalysed by C1GALT1, B3GALT2, B3GALT1, FUT1 and 1 morecytosolOne of 2 routes
a fatty acidReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a globoside Gb3Cer (d18:1(4E)) + UDP + H(+)
3. a globoside Gb3Cer (d18:1(4E)) + H2O = a lysoGb3(d18:1(4E)) + a fatty acid
Catalysed by C1GALT1, A4GALT, ASAH1One of 2 routes
N-acetylneuraminateReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GM1 (d18:1(4E)) + UDP + H(+)
3. a ganglioside GM1 (d18:1(4E)) + H2O = a ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate
Catalysed by C1GALT1, B3GALT4, NEU3One of 3 routes
D-galactoseReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a globoside Gb3Cer (d18:1(4E)) + UDP + H(+)
3. a globoside Gb3Cer (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose
Catalysed by C1GALT1, A4GALT, GLAOne of 4 routes
D-glucoseReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. D-glucose + UDP-alpha-D-galactose = lactose + UDP + H(+)
3. lactose + H2O = beta-D-galactose + D-glucose
Catalysed by C1GALT1, B4GALT2, B4GALT1, LCT
daidzein 7-O-beta-D-glucosideReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose
3. daidzein + UDP-alpha-D-glucose = daidzein 7-O-beta-D-glucoside + UDP
Catalysed by C1GALT1, GALT, UGT3A2
N-acetyl-beta-neuraminic acidReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GM1 (d18:1(4E)) + UDP + H(+)
3. Sialidase, Cytosol (Neu2)
Catalysed by C1GALT1, B3GALT4, NEU2cytosolOne of 3 routes
an N-acylsphing-4-enineReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)
3. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
Catalysed by C1GALT1, UGT8, GBA1, GALC and 2 moreOne of 2 routes
a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. UDP-N-acetyl-alpha-D-glucosamine(out) + UDP-alpha-D-galactose(in) = UDP-N-acetyl-alpha-D-glucosamine(in) + UDP-alpha-D-galactose(out)
3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + UDP + H(+)
Catalysed by C1GALT1, SLC35A2, PIGAinner side of the membrane, outer side of the membrane
N-acetyl-alpha-D-glucosamine 1-phosphateReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. UDP-N-acetyl-alpha-D-glucosamine(out) + UDP-alpha-D-galactose(in) = UDP-N-acetyl-alpha-D-glucosamine(in) + UDP-alpha-D-galactose(out)
3. UDP-N-acetyl-alpha-D-glucosamine + H2O = N-acetyl-alpha-D-glucosamine 1-phosphate + UMP + 2 H(+)
Catalysed by C1GALT1, SLC35A2, ENPP3inner side of the membrane, outer side of the membrane
alpha-D-glucose 1-phosphateReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose
3. alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose
Catalysed by C1GALT1, GALTOne of 3 routes
a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E))Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside nLc4Cer(d18:1(4E)) + UDP + H(+)
3. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by C1GALT1, B4GALT3, B4GALT4, B4GALT1 and 1 morecytosolOne of 2 routes
a ganglioside GM3 (d18:1(4E))Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP + H(+)
3. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by C1GALT1, B4GALT5, B4GALT6, ST3GAL5cytosolOne of 3 routes
CHEBI:67119Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose
3. UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase
Catalysed by C1GALT1, GALTcytosolOne of 2 routes
a ganglioside GM2 (d18:1(4E))Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GM1 (d18:1(4E)) + UDP + H(+)
3. beta-galactosidase (GM1)
Catalysed by C1GALT1, B3GALT4, LCT, GLB1 and 2 morecytosolOne of 5 routes
an N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enineReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)
3. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + 3'-phosphoadenylyl sulfate = an N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)
Catalysed by C1GALT1, UGT8, GAL3ST1
a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E))Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside nLc4Cer(d18:1(4E)) + UDP + H(+)
3. a neolactoside nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)
Catalysed by C1GALT1, B4GALT3, B4GALT4, B4GALT1 and 1 more
beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enineReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP + H(+)
3. a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + 3'-phosphoadenylyl sulfate = beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + adenosine 3',5'-bisphosphate + H(+)
Catalysed by C1GALT1, B4GALT5, B4GALT6, GAL3ST1
a ganglioside GD1a (d18:1(4E))Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GM1 (d18:1(4E)) + UDP + H(+)
3. beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by C1GALT1, B3GALT4, ST3GAL1, ST3GAL4 and 1 morecytosolOne of 3 routes
a ganglioside GT1b (d18:1(4E))Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GD1b (d18:1(4E)) + UDP + H(+)
3. beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by C1GALT1, B3GALT4, ST3GAL1, ST3GAL4 and 1 morecytosolOne of 3 routes
a ganglioside GM4 (d18:1(4E))Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)
3. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate = a ganglioside GM4 (d18:1(4E)) + CMP + H(+)
Catalysed by C1GALT1, UGT8, ST3GAL5
a ganglioside GD2 (d18:1(4E))Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a ganglioside GD2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GD1b (d18:1(4E)) + UDP + H(+)
3. Beta-Galactosidase, Lysosomal
Catalysed by C1GALT1, B3GALT4, GLB1lysosomeOne of 2 routes
a ganglioside GM1b (d18:1(4E))Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GA1 (d18:1(4E)) + UDP + H(+)
3. a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b (d18:1(4E)) + CMP + H(+)
Catalysed by C1GALT1, B3GALT4, ST3GAL1, ST3GAL4 and 1 more
a ganglioside Fuc-GM1 (d18:1(4E))Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a ganglioside GM2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GM1 (d18:1(4E)) + UDP + H(+)
3. a ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose = a ganglioside Fuc-GM1 (d18:1(4E)) + GDP + H(+)
Catalysed by C1GALT1, B3GALT4, FUT2
a ganglioside GM2Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. UDP-N-acetyl-alpha-D-galactosamine(out) + UDP-alpha-D-galactose(in) = UDP-N-acetyl-alpha-D-galactosamine(in) + UDP-alpha-D-galactose(out)
3. a ganglioside GM3 + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GM2 + UDP + H(+)
Catalysed by C1GALT1, SLC35A2, B4GALNT1inner side of the membrane, outer side of the membrane
a ganglioside GD2Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. UDP-N-acetyl-alpha-D-galactosamine(out) + UDP-alpha-D-galactose(in) = UDP-N-acetyl-alpha-D-galactosamine(in) + UDP-alpha-D-galactose(out)
3. a ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GD2 + UDP + H(+)
Catalysed by C1GALT1, SLC35A2, B4GALNT1inner side of the membrane, outer side of the membrane
a ganglioside GD1aReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a ganglioside GM2 + UDP-alpha-D-galactose = a ganglioside GM1 + UDP + H(+)
3. a ganglioside GM1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a + CMP + H(+)
Catalysed by C1GALT1, B3GALT4, ST3GAL1, ST3GAL2
N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramideReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. an N-acyl-sphingoid base + UDP-alpha-D-galactose = a beta-D-Gal-(1<->1')-ceramide + UDP + H(+)
3. a beta-D-Gal-(1<->1')-ceramide + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide + CMP + H(+)
Catalysed by C1GALT1, UGT8, ST3GAL5
a ganglioside GalNAc-GD1aReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. UDP-N-acetyl-alpha-D-galactosamine(out) + UDP-alpha-D-galactose(in) = UDP-N-acetyl-alpha-D-galactosamine(in) + UDP-alpha-D-galactose(out)
3. a ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GalNAc-GD1a + UDP + H(+)
Catalysed by C1GALT1, SLC35A2, B4GALNT1inner side of the membrane, outer side of the membrane
1-(3-O-sulfo-beta-D-galactosyl)-ceramideReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. an N-acyl-sphingoid base + UDP-alpha-D-galactose = a beta-D-Gal-(1<->1')-ceramide + UDP + H(+)
3. a beta-D-Gal-(1<->1')-ceramide + 3'-phosphoadenylyl sulfate = 1-(3-O-sulfo-beta-D-galactosyl)-ceramide + adenosine 3',5'-bisphosphate + H(+)
Catalysed by C1GALT1, UGT8, GAL3ST1
an N-acyl-sphingoid baseReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. an N-acyl-sphingoid base + UDP-alpha-D-galactose = a beta-D-Gal-(1<->1')-ceramide + UDP + H(+)
3. an N-acyl-sphingoid base + UDP-alpha-D-galactose = a beta-D-Gal-(1<->1')-ceramide + UDP + H(+)
Catalysed by C1GALT1, UGT8
a ganglioside GA1Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a ganglioside GM2 + UDP-alpha-D-galactose = a ganglioside GM1 + UDP + H(+)
3. a ganglioside GM1 + H2O = a ganglioside GA1 + N-acetylneuraminate
Catalysed by C1GALT1, B3GALT4, NEU3, NEU2
beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucoseReach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. D-glucose + UDP-alpha-D-galactose = lactose + UDP + H(+)
3. lactose + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+)
Catalysed by C1GALT1, B4GALT2, B4GALT1, FUT3 and 1 more
a ganglioside GA2Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a beta-D-glucosylceramide + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP + H(+)
3. a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GA2 + UDP + H(+)
Catalysed by C1GALT1, B4GALT3, B4GALT1, B4GALNT1One of 2 routes
a ganglioside Fuc-GM1Reach from here →
1. an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)
2. a ganglioside GM2 + UDP-alpha-D-galactose = a ganglioside GM1 + UDP + H(+)
3. a ganglioside GM1 + GDP-beta-L-fucose = a ganglioside Fuc-GM1 + GDP + H(+)
Catalysed by C1GALT1, B3GALT4, FUT1, FUT2