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a ganglioside GM2

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

18 compounds within 3 steps: 5 in 1, 5 in 2, 8 in 3

Does it reach a compound?

One step

N-acetyl-beta-D-galactosamineReach from here →
1. a ganglioside GM2 + H2O = a ganglioside GM3 + N-acetyl-beta-D-galactosamine
Catalysed by HEXA, HEXB
N-acetylneuraminateReach from here →
1. a ganglioside GM2 + H2O = a ganglioside GA2 + N-acetylneuraminate
Catalysed by NEU4, NEU2
a ganglioside GM3Reach from here →
1. a ganglioside GM2 + H2O = a ganglioside GM3 + N-acetyl-beta-D-galactosamine
Catalysed by HEXA, HEXB
a ganglioside GM1Reach from here →
1. a ganglioside GM2 + UDP-alpha-D-galactose = a ganglioside GM1 + UDP + H(+)
Catalysed by B3GALT4
a ganglioside GA2Reach from here →
1. a ganglioside GM2 + H2O = a ganglioside GA2 + N-acetylneuraminate
Catalysed by NEU4, NEU2

Two steps

a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramideReach from here →
1. a ganglioside GM2 + H2O = a ganglioside GM3 + N-acetyl-beta-D-galactosamine
2. a ganglioside GM3 + H2O = a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate
Catalysed by HEXA, HEXB, NEU4, NEU3 and 1 more
a ganglioside GD3Reach from here →
1. a ganglioside GM2 + H2O = a ganglioside GM3 + N-acetyl-beta-D-galactosamine
2. a ganglioside GM3 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD3 + CMP + H(+)
Catalysed by HEXA, HEXB, ST8SIA3,

Three steps

a ganglioside beta-D-GlcNAc-(1->6)-GA1Reach from here →
Catalysed by B3GALT4, NEU3, NEU2, GCNT1
a ganglioside GT3Reach from here →

a ganglioside GD1aReach from here →

a ganglioside GM2 + UDP-alpha-D-galactose = a ganglioside GM1 + UDP + H(+)
a ganglioside GM1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a + CMP + H(+)

Catalysed by B3GALT4, ST3GAL1, ST3GAL2

a ganglioside GA1Reach from here →

a ganglioside GM2 + UDP-alpha-D-galactose = a ganglioside GM1 + UDP + H(+)
a ganglioside GM1 + H2O = a ganglioside GA1 + N-acetylneuraminate

Catalysed by B3GALT4, NEU3, NEU2

a ganglioside Fuc-GM1Reach from here →

a ganglioside GM2 + UDP-alpha-D-galactose = a ganglioside GM1 + UDP + H(+)
a ganglioside GM1 + GDP-beta-L-fucose = a ganglioside Fuc-GM1 + GDP + H(+)

Catalysed by B3GALT4, FUT1, FUT2

Catalysed by HEXA, HEXB, ST8SIA3, ST8SIA6 and 1 more

a ganglioside GD2Reach from here →

a ganglioside GM2 + H2O = a ganglioside GM3 + N-acetyl-beta-D-galactosamine
a ganglioside GM3 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD3 + CMP + H(+)
a ganglioside GD3 + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GD2 + UDP + H(+)

Catalysed by HEXA, HEXB, ST8SIA3, ST8SIA6 and 1 more

a ganglioside GalNAc-GD1aReach from here →

a ganglioside GM2 + UDP-alpha-D-galactose = a ganglioside GM1 + UDP + H(+)
a ganglioside GM1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a + CMP + H(+)
a ganglioside GD1a + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GalNAc-GD1a + UDP + H(+)

Catalysed by B3GALT4, ST3GAL1, ST3GAL2, B4GALNT1

a globoside Gb3CerReach from here →

a ganglioside GM2 + H2O = a ganglioside GM3 + N-acetyl-beta-D-galactosamine
a ganglioside GM3 + H2O = a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate
a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-alpha-D-galactose = a globoside Gb3Cer + UDP + H(+)

Catalysed by HEXA, HEXB, NEU4, NEU3 and 2 more

a ganglioside GM1bReach from here →

a ganglioside GM2 + UDP-alpha-D-galactose = a ganglioside GM1 + UDP + H(+)
a ganglioside GM1 + H2O = a ganglioside GA1 + N-acetylneuraminate
a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b + CMP + H(+)

Catalysed by B3GALT4, NEU3, NEU2, ST3GAL1 and 1 more

a ganglioside Fuc-GA1Reach from here →

a ganglioside GM2 + UDP-alpha-D-galactose = a ganglioside GM1 + UDP + H(+)
a ganglioside GM1 + H2O = a ganglioside GA1 + N-acetylneuraminate
a ganglioside GA1 + GDP-beta-L-fucose = a ganglioside Fuc-GA1 + GDP + H(+)

Catalysed by B3GALT4, NEU3, NEU2, FUT1 and 1 more

a ganglioside GT1aReach from here →

a ganglioside GM2 + UDP-alpha-D-galactose = a ganglioside GM1 + UDP + H(+)
a ganglioside GM1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a + CMP + H(+)
a ganglioside GD1a + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1a + CMP + H(+)

Catalysed by B3GALT4, ST3GAL1, ST3GAL2, ST8SIA6