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a globoside Gb4Cer (d18:1(4E))

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

23 compounds within 3 steps: 2 in 1, 5 in 2, 16 in 3

Does it reach a compound?

One step

a globoside Gb3Cer (d18:1(4E))Reach from here →
1. beta-N-acetylhexosaminidase (globoside)
Catalysed by HEXA, HEXB, HEXDcytosolOne of 2 routes
a globoside GalGb4Cer (d18:1(4E))Reach from here →
1. a globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose = a globoside GalGb4Cer (d18:1(4E)) + UDP + H(+)
Catalysed by B3GALT5

Two steps

a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))Reach from here →
1. beta-N-acetylhexosaminidase (globoside)
2. galactosidase alpha (globotriaosylceramide)
Catalysed by HEXA, HEXB, HEXD, GLAcytosolOne of 3 routes
a lysoGb3(d18:1(4E))Reach from here →
1. beta-N-acetylhexosaminidase (globoside)
2. a globoside Gb3Cer (d18:1(4E)) + H2O = a lysoGb3(d18:1(4E)) + a fatty acid
Catalysed by HEXA, HEXB, HEXD, ASAH1

Three steps

a 3-(acyloxy)acyl derivative of bacterial toxinReach from here →
Catalysed by HEXA, HEXB, HEXD, ASAH1 and 1 morecytosol
D-galactono-1,5-lactoneReach from here →

cytosol

alpha-D-galactoseReach from here →

beta-N-acetylhexosaminidase (globoside)
galactosidase alpha (globotriaosylceramide)

Catalysed by HEXA, HEXB, HEXD, GLAcytosolOne of 3 routes

a fatty acidReach from here →

beta-N-acetylhexosaminidase (globoside)
a globoside Gb3Cer (d18:1(4E)) + H2O = a lysoGb3(d18:1(4E)) + a fatty acid

Catalysed by HEXA, HEXB, HEXD, ASAH1cytosol

D-galactoseReach from here →

beta-N-acetylhexosaminidase (globoside)
a globoside Gb3Cer (d18:1(4E)) + H2O = a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + D-galactose

Catalysed by HEXA, HEXB, HEXD, GLAcytosol

Catalysed by HEXA, HEXB, HEXD, GLA and 1 morecytosol

galactitolReach from here →

beta-N-acetylhexosaminidase (globoside)
galactosidase alpha (globotriaosylceramide)
galactitol:NADP+ 1-oxidoreductase

Catalysed by HEXA, HEXB, HEXD, GLA and 1 morecytosolOne of 2 routes

a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))Reach from here →

beta-N-acetylhexosaminidase (globoside)
galactosidase alpha (globotriaosylceramide)
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase (LacCer pool)

Catalysed by HEXA, HEXB, HEXD, GLA and 1 morecytosolOne of 3 routes

a monoacylglycerolReach from here →

beta-N-acetylhexosaminidase (globoside)
a globoside Gb3Cer (d18:1(4E)) + H2O = a lysoGb3(d18:1(4E)) + a fatty acid
a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)

Catalysed by HEXA, HEXB, HEXD, ASAH1 and 1 morecytosol

D-glucosyl-N-acylsphingosineReach from here →

beta-N-acetylhexosaminidase (globoside)
galactosidase alpha (globotriaosylceramide)
beta-D-Galactosyl-1,4-beta-D-glucosylceramide galactohydrolase

Catalysed by HEXA, HEXB, HEXD, GLA and 4 morecytosol, lysosome

beta-D-galactoseReach from here →

beta-N-acetylhexosaminidase (globoside)
galactosidase alpha (globotriaosylceramide)
galactose[n] = beta-D-galactose[n]

Catalysed by HEXA, HEXB, HEXD, GLA and 1 morecytosol, nucleusOne of 2 routes

a ganglioside GA2 (d18:1(4E))Reach from here →

beta-N-acetylhexosaminidase (globoside)
galactosidase alpha (globotriaosylceramide)
beta-1,4-N-acetyl-galactosaminyltransferase (LacCer pool)

Catalysed by HEXA, HEXB, HEXD, GLA and 1 morecytosolOne of 3 routes

a fatty aldehydeReach from here →

beta-N-acetylhexosaminidase (globoside)
a globoside Gb3Cer (d18:1(4E)) + H2O = a lysoGb3(d18:1(4E)) + a fatty acid
a fatty aldehyde + NAD(+) + H2O = a fatty acid + NADH + 2 H(+)

Catalysed by HEXA, HEXB, HEXD, ASAH1 and 1 morecytosol

an isogloboside iGb3Cer (d18:1(4E))Reach from here →

beta-N-acetylhexosaminidase (globoside)
galactosidase alpha (globotriaosylceramide)
a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = an isogloboside iGb3Cer (d18:1(4E)) + UDP + H(+)

Catalysed by HEXA, HEXB, HEXD, GLA and 1 morecytosol

alpha-D-galactose 1-phosphateReach from here →

beta-N-acetylhexosaminidase (globoside)
galactosidase alpha (globotriaosylceramide)
galactokinase (galactose)

Catalysed by HEXA, HEXB, HEXD, GLA and 2 morecytosolOne of 2 routes

a ganglioside GM3 (d18:1(4E))Reach from here →

beta-N-acetylhexosaminidase (globoside)
galactosidase alpha (globotriaosylceramide)
ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)

Catalysed by HEXA, HEXB, HEXD, GLA and 1 morecytosolOne of 3 routes

an all-trans-retinyl esterReach from here →

beta-N-acetylhexosaminidase (globoside)
a globoside Gb3Cer (d18:1(4E)) + H2O = a lysoGb3(d18:1(4E)) + a fatty acid
an all-trans-retinyl ester + H2O = 11-cis-retinol + a fatty acid + H(+)

Catalysed by HEXA, HEXB, HEXD, ASAH1 and 1 morecytosol

a 1,3-diacyl-sn-glycerolReach from here →

beta-N-acetylhexosaminidase (globoside)
a globoside Gb3Cer (d18:1(4E)) + H2O = a lysoGb3(d18:1(4E)) + a fatty acid
a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)

Catalysed by HEXA, HEXB, HEXD, ASAH1 and 1 morecytosol

a fatty acyl-CoAReach from here →

beta-N-acetylhexosaminidase (globoside)
a globoside Gb3Cer (d18:1(4E)) + H2O = a lysoGb3(d18:1(4E)) + a fatty acid
a fatty acid + ATP + CoA = a fatty acyl-CoA + AMP + diphosphate

Catalysed by HEXA, HEXB, HEXD, ASAH1 and 1 morecytosol

beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enineReach from here →

beta-N-acetylhexosaminidase (globoside)
galactosidase alpha (globotriaosylceramide)
a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + 3'-phosphoadenylyl sulfate = beta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + adenosine 3',5'-bisphosphate + H(+)

Catalysed by HEXA, HEXB, HEXD, GLA and 1 morecytosol