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Proteins/UNIPROT:Q99999
Catalyzes the transfer of a sulfate group to position 3 of non-reducing beta-galactosyl residues in glycerolipids and sphingolipids, therefore participates in the biosynthesis of sulfoglycolipids. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro)..
Function from UniProtKB (Q99999), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
27 statements
27 statements · 5 reference databases · Subject: GAL3ST1 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
12 reactions
CHEBI:12947+3'-phospho-5'-adenylyl sulfateproton+adenosine 3',5'-bismonophosphate+an N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine
Catalysed by GAL3ST1
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.11lysosome
Human-GEM MAR00792CC BY 4.0Reference data
3'-phospho-5'-adenylyl sulfate+psychosineproton+adenosine 3',5'-bismonophosphate+MAM02809c
5 names
Resolves to: GAL3ST1
Catalysed by GAL3ST1
Reaction pageReversibleBalancedEC 2.8.2.11cytosol
Human-GEM MAR00915CC BY 4.0Reference data
a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+3'-phospho-5'-adenylyl sulfateMAM02334c+adenosine 3',5'-bismonophosphate
Catalysed by GAL3ST1
Reaction pageReversibleBalance undeterminableEC 2.8.2.11cytosol
Human-GEM MAR00928CC BY 4.0Reference data
3'-phospho-5'-adenylyl sulfate+psychosineproton+adenosine 3',5'-bismonophosphate+MAM02809g
Catalysed by GAL3ST1
Reaction pageLeft to rightBalancedEC 2.8.2.11Golgi apparatus
Human-GEM MAR03251CC BY 4.0Reference data
3'-phospho-5'-adenylyl sulfate+MAM03586gMAM02334g+adenosine 3',5'-bismonophosphate
Catalysed by GAL3ST1
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.11Golgi apparatus
Human-GEM MAR03253CC BY 4.0Reference data
CHEBI:12947+3'-phospho-5'-adenylyl sulfateproton+adenosine 3',5'-bismonophosphate+MAM02947g
Catalysed by GAL3ST1
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.11Golgi apparatus
Human-GEM MAR08206CC BY 4.0Reference data
MAM01694g+3'-phospho-5'-adenylyl sulfateMAM01695g+proton+adenosine 3',5'-bismonophosphate
Catalysed by GAL3ST1
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.11Golgi apparatus
Human-GEM MAR08212CC BY 4.0Reference data
a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine+3'-phosphoadenylyl sulfatean N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine+adenosine 3',5'-bisphosphate+hydron
Catalysed by GAL3ST1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:20613CC BY 4.0Reference data
a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+3'-phosphoadenylyl sulfatebeta-D-3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine+adenosine 3',5'-bisphosphate+hydron
Catalysed by GAL3ST1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41736CC BY 4.0Reference data
a 1-O-alkyl-2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol+3'-phosphoadenylyl sulfatea 1-O-alkyl-2-acyl-3-(beta-D-3-sulfogalactosyl)-sn-glycerol+adenosine 3',5'-bisphosphate+hydron
Catalysed by GAL3ST1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41744CC BY 4.0Reference data
a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol+3'-phosphoadenylyl sulfate1,2-diacyl-3-(3-O-sulfo-beta-D-galactosyl)-sn-glycerol+adenosine 3',5'-bisphosphate+hydron
Catalysed by GAL3ST1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41748CC BY 4.0Reference data
a beta-D-Gal-(1<->1')-ceramide+3'-phosphoadenylyl sulfate1-(3-O-sulfo-beta-D-galactosyl)-ceramide+adenosine 3',5'-bisphosphate+hydron
Catalysed by GAL3ST1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:43304CC BY 4.0Reference data