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Proteins/UNIPROT:O43825
Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues..
Function from UniProtKB (O43825), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
26 statements
26 statements · 6 reference databases · Subject: B3GALT2 · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
8 reactions
D-glucosyl-N-acylsphingosine+CHEBI:67119proton+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP
Catalysed by GLT8D1 or B4GALT7 or PIGV or B4GALT1 or GALNT7 or B4GALT2 or A4GNT or B4GALT6 or PIGZ or GLT8D2 or B4GALT4 or GCNT7 and 23 more alternatives
4 names
Resolves to: B3GALT2
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-endoplasmic reticulum
Human-GEM MAR00765CC BY 4.0Reference data
a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+CHEBI:67119proton+a beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E))+UDP
Catalysed by B3GALT2 or B3GALT1 or B3GALT5
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.86cytosol
Human-GEM MAR00860CC BY 4.0Reference data
CHEBI:12947+CHEBI:67119MAM01694c+proton+UDP
Catalysed by GLT8D1 or B4GALT7 or B4GALT1 or B4GALT2 or A4GNT or B4GALT6 or GLT8D2 or B4GALT4 or GCNT7 or GBGT1 or B4GALT5 or B4GALT3 and 10 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-cytosol
Human-GEM MAR00924CC BY 4.0Reference data
CHEBI:12947+CHEBI:67119MAM01694g+proton+UDP
Catalysed by GLT8D1 or B4GALT7 or POMGNT1 or B4GALT1 or GALNT7 or B4GALT2 or A4GNT or B4GALT6 or PIGZ or GLT8D2 or B4GALT4 or GCNT7 and 16 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR00925CC BY 4.0Reference data
D-glucosyl-N-acylsphingosine+CHEBI:67119proton+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP
Catalysed by GLT8D1 or B4GALT7 or B4GALT1 or B4GALT2 or A4GNT or B4GALT6 or GLT8D2 or B4GALT4 or GCNT7 or GBGT1 or B4GALT5 or B4GALT3 and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-cytosol
Human-GEM MAR00926CC BY 4.0Reference data
a beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP-alpha-D-galactosea beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1(4E))+UDP+hydron
Catalysed by B3GALT2 or B3GALT1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:16045CC BY 4.0Reference data
a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E))+UDP-alpha-D-galactosea neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E))+UDP+hydron
Catalysed by B3GALT2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:41936CC BY 4.0Reference data
an N-acetyl-beta-D-glucosaminyl derivative+UDP-alpha-D-galactosea beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative+UDP+hydron
Catalysed by B3GALT2 or B3GALT1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:53432CC BY 4.0Reference data