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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q3SY77

UGT3A2

Protein·UNIPROT:Q3SY77

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[Isoform 1]: Involved in biotransformation reactions in which lipophilic substrates are conjugated with sugars to increase water solubility and enhance excretion. Such reactions are of major importance in the elimination of potentially toxic xenobiotics and endogenous compounds. UGT3A2 catalyzes the addition of sugar residues from UDP-glucose and UDP-xylose to a broad range of acceptor substrates including 4-methylumbelliferone, 1-hydroxypyrene, bioflavones, and estrogens. It has negligible activity toward bile acids and androgens. To a lesser extent, is also able to use UDP-galactose but is inactive with UDP-glucuronic acid or UDP-N-acetylglucosamine as sugar donors..

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[Isoform 2]: Lacks UDP-glycosyltransferase activity..

Function from UniProtKB (Q3SY77), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

35 statements

35 statements · 4 reference databases · Subject: UGT3A2 · Sources: Hetionet, Human-GEM, Reactome, Rhea

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UGT3A2 covaries with C16orf78ProteinHetionet hetionet:covaries:123970-167127Inferred only
UGT3A2 covaries with ORC6ProteinHetionet hetionet:covaries:167127-23594Inferred only
UGT3A2 covaries with PHKBProteinHetionet hetionet:covaries:167127-5257Inferred only
UGT3A2 covaries with PIK3IP1ProteinHetionet hetionet:covaries:113791-167127Inferred only
SPACA1 covaries with UGT3A2ProteinHetionet hetionet:covaries:167127-81833Inferred only
TRIM14 covaries with UGT3A2ProteinHetionet hetionet:covaries:167127-9830Inferred only
UFL1 covaries with UGT3A2ProteinHetionet hetionet:covaries:167127-23376Inferred only
(2S)-naringenin is metabolised by UGT3A2CompoundRhea RHEA:65152Inferred only
(2S)-naringenin 7-O-beta-D-glucoside is metabolised by UGT3A2CompoundRhea RHEA:65152Inferred only
17beta-estradiol is metabolised by UGT3A2CompoundHuman-GEM MAR07648Inferred only
3,3'-diiodo-L-thyronine is metabolised by UGT3A2CompoundHuman-GEM MAR06830Inferred only
3,3'-diiodo-L-thyronine is metabolised by UGT3A2CompoundHuman-GEM MAR06828Inferred only

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3,3',5-triiodo-L-thyronine is metabolised by UGT3A2CompoundHuman-GEM MAR06798Inferred only
3,3',5-triiodo-L-thyronine is metabolised by UGT3A2CompoundHuman-GEM MAR06799Inferred only
all-trans-4-hydroxyretinoate is metabolised by UGT3A2CompoundHuman-GEM MAR06705Inferred only
all-trans-4-hydroxyretinoate is metabolised by UGT3A2CompoundHuman-GEM MAR06704Inferred only
bilirubin IXalpha is metabolised by UGT3A2CompoundHuman-GEM MAR04766Inferred only
daidzein is metabolised by UGT3A2CompoundRhea RHEA:56048Inferred only
daidzein 7-O-beta-D-glucoside is metabolised by UGT3A2CompoundRhea RHEA:56048Inferred only
genistein is metabolised by UGT3A2CompoundRhea RHEA:56056Inferred only
genistein 7-O-beta-D-glucoside is metabolised by UGT3A2CompoundRhea RHEA:56056Inferred only
L-thyroxine is metabolised by UGT3A2CompoundHuman-GEM MAR06800Inferred only
L-thyroxine is metabolised by UGT3A2CompoundHuman-GEM MAR06801Inferred only
UDP-alpha-D-glucose is metabolised by UGT3A2CompoundRhea RHEA:17497Inferred only
UDP-alpha-D-glucose is metabolised by UGT3A2CompoundRhea RHEA:65152Inferred only
UDP-alpha-D-glucose is metabolised by UGT3A2CompoundRhea RHEA:56344Inferred only
UDP-alpha-D-glucose is metabolised by UGT3A2CompoundRhea RHEA:56056Inferred only
UDP-alpha-D-glucose is metabolised by UGT3A2CompoundRhea RHEA:56048Inferred only
UDP-alpha-D-glucose is metabolised by UGT3A2CompoundRhea RHEA:55416Inferred only
UGT3A2 participates in Aspirin ADMEPathwayReactome R-HSA-9749641Inferred only
UGT3A2 participates in Biological oxidationsPathwayReactome R-HSA-211859Inferred only
UGT3A2 participates in Drug ADMEPathwayReactome R-HSA-9748784Inferred only
UGT3A2 participates in GlucuronidationPathwayReactome R-HSA-156588Inferred only
UGT3A2 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
UGT3A2 participates in Phase II - Conjugation of compoundsPathwayReactome R-HSA-156580Inferred only

Reactions

43 reactions

MAM01220c+UDP-alpha-D-glucuronateMAM01240c+proton+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction page

Other names

1 name

Resolves to: UGT3A2

Also called: UDPGT 3A2

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Reversible

Balanced

EC 2.4.1.17

cytosol

Human-GEM MAR02461CC BY 4.0Reference data

MAM01220r+UDP-alpha-D-glucuronateMAM01240r+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02462CC BY 4.0Reference data

MAM00274c+proton+UDPMAM01220c+UDP-alpha-D-glucuronate

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageReversibleBalancedEC 2.4.1.17cytosol

Human-GEM MAR02463CC BY 4.0Reference data

MAM01220r+UDP-alpha-D-glucuronateMAM00274r+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02464CC BY 4.0Reference data

MAM00314c+UDP-alpha-D-glucuronateMAM00323c+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageReversibleBalancedEC 2.4.1.17cytosol

Human-GEM MAR02467CC BY 4.0Reference data

MAM00314r+UDP-alpha-D-glucuronateMAM00323r+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02468CC BY 4.0Reference data

MAM00314c+UDP-alpha-D-glucuronateMAM00327c+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageReversibleBalancedEC 2.4.1.17cytosol

Human-GEM MAR02469CC BY 4.0Reference data

MAM00314r+UDP-alpha-D-glucuronateMAM00327r+proton+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR02470CC BY 4.0Reference data

bilirubin IXalpha+2UDP-alpha-D-glucuronateMAM01397r+2UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum

Human-GEM MAR04766CC BY 4.0Reference data

MAM01923c+UDP-alpha-D-glucuronateMAM01924c+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17cytosol

Human-GEM MAR06490CC BY 4.0Reference data

MAM00766c+UDP-alpha-D-glucuronateMAM01321c+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17cytosol

Human-GEM MAR06495CC BY 4.0Reference data

MAM01231c+UDP-alpha-D-glucuronateall-trans-retinoyl-1-O-(beta-D-glucuronate)+UDP

Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives

Reaction pageLeft to rightBalancedEC 2.4.1.17cytosol

Human-GEM MAR06666CC BY 4.0Reference data

Show the remaining 31