Compound

an N-acyl-sphingoid base

Members of the class of neutral glycosphingolipids. They are the basic units of sphingolipids. They are sphingoids attached via their amino groups to a long chain fatty acyl group. They abnormally accumulate in fabry disease.

Definition from MeSH (D002518), National Library of Medicine, read 2026-09-23. NLM revises MeSH; this copy may not reflect its current record.

CHEBI:83273ChEBI

Open in the graph

Structure

2D depiction

Class: Structural class, not a single molecule
Formula: C4H7NO3R2
Mass: 117.103 g/mol
Charge: 0
SMILES: [1*][C@@H](O)[C@H](CO)NC([2*])=O
Look it up: ChEBI

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

4 entities

4 entities reached.

0 reported hops4 assembled from the scaffold

What the reference databases state

Statements

4 statements

4 statements · 1 reference database · Subject: an N-acyl-sphingoid base · Sources: Rhea

Order

an N-acyl-sphingoid base is metabolised by UGT8ProteinRhea RHEA:48344Inferred only
an N-acyl-sphingoid base is a substrate of GALCProteinRhea RHEA:43412Inferred only
an N-acyl-sphingoid base is a substrate of SMPD2ProteinRhea RHEA:45300Inferred only
an N-acyl-sphingoid base is a substrate of SMPD3ProteinRhea RHEA:45300Inferred only

Reactions

21 reactions

CHEBI:136875+waterCHEBI:156536+an N-acyl-sphingoid base
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:22288CC BY 4.0Reference data
a D-galactosylceramide+wateran N-acyl-sphingoid base+D-galactose
Catalysed by GALC
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:43412CC BY 4.0Reference data
an N-(acyl)-sphingosylphosphocholine+wateran N-acyl-sphingoid base+phosphocholine+hydron
Catalysed by SMPD2 or SMPD3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:45300CC BY 4.0Reference data
CDP-ethanolamine+an N-acyl-sphingoid baseCHEBI:73202+CMP+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:45896CC BY 4.0Reference data
an N-acyl-sphingoid base+UDP-alpha-D-galactosea beta-D-Gal-(1<->1')-ceramide+UDP+hydron
Catalysed by UGT8
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:48344CC BY 4.0Reference data
CHEBI:84404+wateran N-acyl-sphingoid base+hydrogenphosphate
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:50888CC BY 4.0Reference data
a sphingoid base+a fatty acyl-CoAan N-acyl-sphingoid base+coenzyme A(4-)+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:53424CC BY 4.0Reference data
an N-acyl-sphingoid base+a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)CHEBI:64916+a 1,2-diacyl-sn-glycerol
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:55588CC BY 4.0Reference data
CHEBI:64916+water1D-myo-inositol 1-phosphate+an N-acyl-sphingoid base+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:55692CC BY 4.0Reference data
CHEBI:64997+waterCHEBI:139147+an N-acyl-sphingoid base+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:55696CC BY 4.0Reference data
a ganglioside GM3+waterN-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-D-glucose+an N-acyl-sphingoid base
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:65540CC BY 4.0Reference data
a ganglioside GM1+waterCHEBI:156537+an N-acyl-sphingoid base
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:65544CC BY 4.0Reference data

Show the remaining 9

Other names

3 names

Resolves to: an N-acyl-sphingoid base

Also called: CerCeramideN-acylsphingoids