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Proteins/UNIPROT:Q9UNA3
Catalyzes the transfer of N-acetylglucosamine (GlcNAc) residues from UDP-N-acetyl-alpha-D-glucosamine donnors to beta (1->4)-linked or beta-(1->3)-linked galactose residues on O-glycans like core 2 branched O-glycans. Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct. May protect against inflammation-associated gastric adenocarcinomas (By similarity)..
Function from UniProtKB (Q9UNA3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
24 statements
24 statements · 5 reference databases · Subject: A4GNT · Sources: Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea
11 reactions
D-glucosyl-N-acylsphingosine+CHEBI:67119proton+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP
Catalysed by GLT8D1 or B4GALT7 or PIGV or B4GALT1 or GALNT7 or B4GALT2 or A4GNT or B4GALT6 or PIGZ or GLT8D2 or B4GALT4 or GCNT7 and 23 more alternatives
1 name
Resolves to: A4GNT
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-endoplasmic reticulum
Human-GEM MAR00765CC BY 4.0Reference data
CHEBI:12947+CHEBI:67119MAM01694c+proton+UDP
Catalysed by GLT8D1 or B4GALT7 or B4GALT1 or B4GALT2 or A4GNT or B4GALT6 or GLT8D2 or B4GALT4 or GCNT7 or GBGT1 or B4GALT5 or B4GALT3 and 10 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-cytosol
Human-GEM MAR00924CC BY 4.0Reference data
CHEBI:12947+CHEBI:67119MAM01694g+proton+UDP
Catalysed by GLT8D1 or B4GALT7 or POMGNT1 or B4GALT1 or GALNT7 or B4GALT2 or A4GNT or B4GALT6 or PIGZ or GLT8D2 or B4GALT4 or GCNT7 and 16 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR00925CC BY 4.0Reference data
D-glucosyl-N-acylsphingosine+CHEBI:67119proton+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP
Catalysed by GLT8D1 or B4GALT7 or B4GALT1 or B4GALT2 or A4GNT or B4GALT6 or GLT8D2 or B4GALT4 or GCNT7 or GBGT1 or B4GALT5 or B4GALT3 and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-cytosol
Human-GEM MAR00926CC BY 4.0Reference data
MAM02960g+CHEBI:16264MAM01954g+proton+UDP
Catalysed by A4GNT
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR08254CC BY 4.0Reference data
MAM01607g+CHEBI:16264MAM01955g+proton+UDP
Catalysed by A4GNT
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-Golgi apparatus
Human-GEM MAR08255CC BY 4.0Reference data
a beta-D-galactoside+UDP-N-acetyl-alpha-D-glucosaminean N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-galactosyl derivative+UDP+hydron
Catalysed by A4GNT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:85983CC BY 4.0Reference data
a 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein]+UDP-N-acetyl-alpha-D-glucosaminea 3-O-{alpha-D-GlcNAc-(1->4)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein]+UDP+hydron
Catalysed by A4GNT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:86035CC BY 4.0Reference data
a 3-O-{beta-D-Gal-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein]+2UDP-N-acetyl-alpha-D-glucosaminea 3-O-{alpha-D-GlcNAc-(1->4)-beta-D-Gal-(1->3)-[alpha-D-GlcNAc-(1->4)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-threonyl-[protein]+2UDP+2hydron
Catalysed by A4GNT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:86039CC BY 4.0Reference data
a 3-O-{beta-D-Gal-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein]+2UDP-N-acetyl-alpha-D-glucosaminea 3-O-{alpha-D-GlcNAc-(1->4)-beta-D-Gal-(1->3)-[alpha-D-GlcNAc-(1->4)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein]+2UDP+2hydron
Catalysed by A4GNT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:86043CC BY 4.0Reference data
3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein]+UDP-N-acetyl-alpha-D-glucosaminea 3-O-{alpha-D-GlcNAc-(1->4)-beta-D-Gal-(1->3)-[beta-D-GlcNAc-(1->6)]-alpha-D-GalNAc}-L-seryl-[protein]+UDP+hydron
Catalysed by A4GNT
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:86059CC BY 4.0Reference data