CHEBI:1146900

Two steps

• S-methyl-5'-thioadenosineReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermidine)
  2. S-adenosylmethioninamine:spermidine 3-aminopropyltransferase

  Catalysed by SAT1, SAT2, SRM, SMScytosolOne of 2 routes

• 5-aminolevulinic acidReach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by GLYAT, GLYATL2, GLYATL1, ALAS1 and 2 moremitochondrial matrixOne of 2 routes

• all-trans-retinyl hexadecanoateReach from here →
  1. Palmitoyl-CoA:retinol O-acyltransferase
  2. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)

  Catalysed by DGAT1, LRAT, AWAT1, AWAT2 and 2 morecytosol

• Ala-tRNA(Ala)Reach from here →
  1. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  2. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by AARS1mitochondrial matrix, cytosol

• CHEBI:17769Reach from here →
  1. diamine N-acetyltransferase (N1-acetylspermidine)
  2. spermidine:(acceptor) oxidoreductase

  Catalysed by SAT1, SAT2cytosol

• a 1,2-diacyl-sn-glycerolReach from here →
  1. acyl-CoA:sphingosine N-acyltransferase
  2. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA

  Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 3 moreGolgi apparatus

• a triacylglycerolReach from here →
  1. acyl-CoA:sphingosine N-acyltransferase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

  Catalysed by ASAH1, ACER2, ACER1, ASAH2 and 5 moreGolgi apparatus, cytosol

• CHEBI:17895Reach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. transport of glycine and tyrosine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 19 routes

• butanoateReach from here →
  1. Butanoate:CoA ligase (AMP-forming)
  2. butanoyl-CoA + H2O = butanoate + CoA + H(+)

  Catalysed by ACSM4, ACSM1, ACSM2A, ACSM3 and 8 morecytosol

• CHEBI:18019Reach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. transport of glycine and lysine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 10 routes

• L-glutamineReach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 29 routes

• spermine monoaldehydeReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermine)
  2. primary-amine oxidase (spermine)

  Catalysed by SAT1, SAT2, AOC2, AOC1 and 1 morecytosolOne of 3 routes

• CHEBI:18095Reach from here →
  1. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  2. Transport of Hydroxy-Proline

  Catalysed by SLC1A4mitochondrial matrix, extracellular space, cytosol

• O-octanoyl-(R)-carnitineReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. solute carrier (L-carnitine)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC25A20cytosol, mitochondrial matrixOne of 11 routes

• CHEBI:18132Reach from here →
  1. Acetyl-CoA:choline O-acetyltransferase
  2. ATP:choline phosphotransferase

  Catalysed by CHAT, CHKA, CHKBnucleus, cytosol

• dodecanoateReach from here →
  1. long-chain-fatty-acid-CoA ligase (lauric acid)
  2. Lauroyl-CoA hydrolase

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 8 morecytosolOne of 2 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by GLYAT, GLYATL2, GLYATL1, GARTmitochondrial matrix, cytosol

• N-(4-aminobutyl)-3-aminopropanalReach from here →
  1. diamine N-acetyltransferase (N1-acetylspermidine)
  2. primary-amine oxidase (spermidine)

  Catalysed by SAT1, SAT2, AOC2, AOC1 and 1 morecytosolOne of 3 routes

• (2E,5Z,8Z,11Z,14Z,17Z)-eicosahexaenoyl-CoAReach from here →
  1. long-chain-fatty-acid-CoA ligase (EPA)
  2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z,17Z)-eicosahexaenoyl-CoA + H2O2

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 5 morecytosol

• 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. long-chain-fatty-acid-CoA ligase (stearate)
  2. a 2-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosol

• ophthalmateReach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSSmitochondrial matrix

• S-methylmercury-L-cysteineReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by NAGS, SLC7A8mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-aminoisobutanoateReach from here →
  1. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  2. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by SLC7A10mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 11-cis-retinyl esterReach from here →
  1. Palmitoyl-CoA:retinol O-acyltransferase
  2. 11-cis-retinol + a fatty acyl-CoA = 11-cis-retinyl ester + CoA

  Catalysed by DGAT1, LRAT, AWAT1, AWAT2 and 1 morecytosol

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. ATP citrate lyase (citrate)
  2. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by ACLY, AGXT2cytosol

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by GLYAT, GLYATL2, GLYATL1, AGXT2mitochondrial matrixOne of 2 routes

• 1-butanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. Butanoate:CoA ligase (AMP-forming)
  2. 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by ACSM4, ACSM1, ACSM2A, ACSM3 and 4 morecytosol

• 1-octanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. 2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by CROT, MOGAT2, MOGAT1mitochondrial matrix

• 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. long-chain-fatty-acid-CoA ligase (eicosanoate)
  2. eicosanoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 6 morecytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by GLYAT, GLYATL2, GLYATL1, SHMT1mitochondrial matrix, cytosolOne of 2 routes

• O-butanoyl-(R)-carnitineReach from here →
  1. Butanoate:CoA ligase (AMP-forming)
  2. butanoyl-CoA + (R)-carnitine = O-butanoyl-(R)-carnitine + CoA

  Catalysed by ACSM4, ACSM1, ACSM2A, ACSM3 and 3 morecytosol

• S-disulfanyl-L-cysteineReach from here →
  1. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  2. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by NAGS, CARS2mitochondrial matrix

• 3-oxo-(9Z)-eicosenoyl-CoAReach from here →
  1. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)
  2. very-long-chain 3-oxoacyl-CoA synthase ((7Z)-octadecenoyl-CoA)

  Catalysed by CPT1A, CPT1C, CPT1B, ELOVL7 and 6 morecytosol

• (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoAReach from here →
  1. long-chain-fatty-acid-CoA ligase (gamma-linolenate)
  2. (6Z,9Z,12Z)-octadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 7 morecytosolOne of 2 routes

• (2E,7Z,10Z)-hexadecatrienoyl-CoAReach from here →
  1. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial
  2. (7Z,10Z)-hexadecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z,10Z)-hexadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by HADHA, ACADVL, HADHB, ACADL and 1 moremitochondrial matrix

• (2E,4Z,7Z,10Z,13Z)-hexadecapentaenoyl-CoAReach from here →
  1. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial
  2. Fatty Acid Beta Oxidation (C16:4->C16:5), Mitochondrial

  Catalysed by HADHA, ACADVL, HADHBmitochondrial matrixOne of 4 routes

• (2E,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial
  2. (7Z,10Z,13Z)-hexadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z,10Z,13Z)-hexadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by HADHA, ACADVL, HADHB, ACADL and 1 moremitochondrial matrix

• (2E,4Z,7Z)-decatrienoyl-CoAReach from here →
  1. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial
  2. Fatty Acid Beta Oxidation (C10:2->C10:3), Mitochondrial

  Catalysed by ECHS1, ACAA2, HADH, ACADMmitochondrial matrixOne of 3 routes

• docosanoateReach from here →
  1. long-chain-fatty-acid-CoA ligase (behenic acid)
  2. Docosanoyl-CoA hydrolase

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 6 morecytosolOne of 4 routes

• CHEBI:240943Reach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by GLYAT, GLYATL2, GLYATL1mitochondrial matrixOne of 2 routes

• octadecanoateReach from here →
  1. long-chain-fatty-acid-CoA ligase (stearate)
  2. Stearoyl-CoA hydrolase

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 8 morecytosolOne of 4 routes

• octanoateReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. Octanoyl-CoA hydrolase

  Catalysed by CROT, ACOT7mitochondrial matrix, cytosolOne of 2 routes

• alpha-linolenic acidReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. Utilized Transport

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol, endoplasmic reticulumOne of 2 routes

• phenylacetylglycineReach from here →
  1. glycine N-acyltransferase (N-arachidonoylglycine)
  2. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by GLYAT, GLYATL2, GLYATL1mitochondrial matrix, cytosolOne of 6 routes

• decanoateReach from here →
  1. medium-chain acyl-CoA ligase (decanoic acid)
  2. Decanoyl-CoA hydrolase

  Catalysed by ACSM4, ACSM1, ACSM2A, ACSM3 and 3 morecytosolOne of 2 routes

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. long-chain-fatty-acid-CoA ligase (DHA)
  2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 6 morecytosolOne of 2 routes

• hexacosan-1-olReach from here →
  1. long-chain-fatty-acid-CoA ligase (cerotic acid)
  2. hexacosanoyl-CoA + 2 NADPH + 2 H(+) = hexacosan-1-ol + 2 NADP(+) + CoA

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 5 morecytosol

• CHEBI:28666Reach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. LTD4 hydrolysis

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 28 morecytosolOne of 2 routes

• O-decanoyl-(R)-carnitineReach from here →
  1. medium-chain acyl-CoA ligase (decanoic acid)
  2. decanoyl-CoA + (R)-carnitine = O-decanoyl-(R)-carnitine + CoA

  Catalysed by ACSM4, ACSM1, ACSM2A, ACSM3 and 4 morecytosol

• pyridoxine 5'-phosphateReach from here →
  1. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SCLYmitochondrial matrix, cytosol