Calnexin/calreticulin cycle

The unfolded protein is recognized by a chaperon protein (calnexin or calreticulin) and the folding process starts. The binding of these protein requires a mono-glucosylated glycan (Caramelo JJ and Parodi AJ, 2008) and lectin-based interaction with client proteins is the predominant contributor to chaperone activity of calreticulin (inferred from the mouse homolog in Lum et al. 2016).

Summary from Reactome (R-HSA-901042), read 2026-09-23.