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Proteins/UNIPROT:O75190
Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Also reduces cellular toxicity and caspase-3 activity..
[Isoform B]: Isoform B but not isoform A inhibits huntingtin aggregation..
Function from UniProtKB (O75190), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
126 statements
126 statements · 3 reference databases · Subject: DNAJB6 · Sources: gene ontology, Hetionet, Reactome
7 names
Resolves to: DNAJB6