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Proteins/UNIPROT:Q8N7B1
Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity)..
Function from UniProtKB (Q8N7B1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
40 statements
40 statements · 2 reference databases · Subject: HORMAD2 · Sources: Hetionet, WikiPathways
1 name
Resolves to: HORMAD2