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Proteins/UNIPROT:Q9Y5B8
Possesses an intrinsic kinase activity. Phosphorylates GSK3B at 'Ser-9', leading to the activation of Wnt/beta-catenin signaling. Additionally, exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double-stranded DNA substrates, possibly participating in DNA nucleolytic processing. In vitro, does not seem to have nucleoside diphosphate kinase activity. Functional component of the gamma-tubulin ring complex, implicated in the regulation of its microtubule-nucleating activity in centrosomes, in a kinase activity-dependent manner. May maintain primary cilium assembly and ciliary microtubule stability. Part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, required for motile cilia beating..
Function from UniProtKB (Q9Y5B8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
88 statements
88 statements · 5 reference databases · Subject: NME7 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, WikiPathways
19 reactions
5 names
Resolves to: NME7
Reaction pageReversibleBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR04018CC BY 4.0Reference data
ADP+CHEBI:16284ATP+CHEBI:16174
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageLeft to rightBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR04420CC BY 4.0Reference data
ADP+CHEBI:16497ATP+CHEBI:28862
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04570CC BY 4.0Reference data
ADP+CHEBI:16497ATP+CHEBI:28862
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageLeft to rightBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR04572CC BY 4.0Reference data
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04635CC BY 4.0Reference data
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04670CC BY 4.0Reference data
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04673CC BY 4.0Reference data
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageLeft to rightBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR04675CC BY 4.0Reference data
Transported by NME3 or NME4 or NME7 or AK9 or NME6 or NME1 or NME2
Reaction pageLeft to rightBalancedendoplasmic reticulum, cytosol
Human-GEM MAR04906CC BY 4.0Reference data
Transported by NME3 or NME4 or NME7 or AK9 or NME6 or NME1 or NME2
Reaction pageLeft to rightBalancedlysosome, cytosol
Human-GEM MAR04907CC BY 4.0Reference data
Transported by NME3 or NME4 or NME7 or AK9 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedcytosol, peroxisome
Human-GEM MAR04908CC BY 4.0Reference data