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Proteins/UNIPROT:O14732
Phosphatase that can use myo-inositol monophosphates, myo-inositol 1,4-diphosphate, scyllo-inositol-1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate and 2'-AMP as substrates in vitro. It is likely that IMPA2 has an as yet unidentified in vivo substrate(s). Has been implicated as the pharmacological target for lithium (Li(+)) action in brain..
Function from UniProtKB (O14732), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
123 statements
123 statements · 6 reference databases · Subject: IMPA2 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt
13 reactions
water+1D-myo-inositol 1-phosphatemyo-inositol+phosphate(3-)
Reaction pageLeft to rightBalancedEC 3.1.3.25cytosol
Human-GEM MAR06540CC BY 4.0Reference data
MAM00530c+watermyo-inositol+phosphate(3-)
5 names
Resolves to: IMPA2
Human-GEM MAR06562CC BY 4.0Reference data
1D-myo-inositol 3-phosphate+watermyo-inositol+phosphate(3-)
Reaction pageLeft to rightBalancedEC 3.1.3.25cytosol
Human-GEM MAR06571CC BY 4.0Reference data
glycerol 2-phosphate+waterglycerol+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:13105CC BY 4.0Reference data
alpha-D-glucose 1-phosphate+waterD-glucose+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:19933CC BY 4.0Reference data
CHEBI:84139+watermyo-inositol+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:24056CC BY 4.0Reference data
1D-myo-inositol 1-phosphate+watermyo-inositol+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:27670CC BY 4.0Reference data
CHEBI:58469+watermyo-inositol+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:30735CC BY 4.0Reference data
1D-myo-inositol 3-phosphate+watermyo-inositol+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:30739CC BY 4.0Reference data
CHEBI:77740+wateradenosine+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:37343CC BY 4.0Reference data
CHEBI:84142+watermyo-inositol+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:44152CC BY 4.0Reference data
CHEBI:84141+watermyo-inositol+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:44156CC BY 4.0Reference data