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Proteins/UNIPROT:P34913
Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators..
Bifunctional enzyme. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid. Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates..
Function from UniProtKB (P34913), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
116 statements
116 statements · 9 reference databases · Subject: EPHX2 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
66 reactions
5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate+waterMAM01051c
Reaction pageLeft to rightBalancedEC 3.3.2.9, 3.3.2.10cytosol
Human-GEM MAR00945CC BY 4.0Reference data
8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate+waterMAM01208c
Reaction pageLeft to rightBalancedEC 3.3.2.9, 3.3.2.10cytosol
5 names
Resolves to: EPHX2
MAM00279c+waterMAM00277c
Reaction pageLeft to rightBalancedEC 3.3.2.9, 3.3.2.10cytosol
Human-GEM MAR00953CC BY 4.0Reference data
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate+waterMAM00364c
Reaction pageLeft to rightBalancedEC 3.3.2.9, 3.3.2.10cytosol
Human-GEM MAR00957CC BY 4.0Reference data
MAM00098c+waterMAM00386c
Reaction pageReversibleBalancedEC 3.3.2.9, 3.3.2.10cytosol
Human-GEM MAR01002CC BY 4.0Reference data
MAM00098x+waterMAM00386x
Reaction pageReversibleBalancedEC 3.3.2.9, 3.3.2.10peroxisome
Human-GEM MAR01003CC BY 4.0Reference data
MAM00098r+waterMAM00386r
Reaction pageReversibleBalancedEC 3.3.2.9, 3.3.2.10endoplasmic reticulum
Human-GEM MAR01004CC BY 4.0Reference data
MAM00098c+waterMAM00388c
Reaction pageReversibleBalancedEC 3.3.2.9, 3.3.2.10cytosol
Human-GEM MAR01006CC BY 4.0Reference data
MAM00098x+waterMAM00388x
Reaction pageReversibleBalancedEC 3.3.2.9, 3.3.2.10peroxisome
Human-GEM MAR01007CC BY 4.0Reference data
MAM00098r+waterMAM00388r
Reaction pageReversibleBalancedEC 3.3.2.9, 3.3.2.10endoplasmic reticulum
Human-GEM MAR01008CC BY 4.0Reference data
MAM01058c+waterMAM02396c
Reaction pageReversibleBalancedEC 3.3.2.9, 3.3.2.10cytosol
Human-GEM MAR01020CC BY 4.0Reference data
MAM01058n+waterMAM02396n
Reaction pageReversibleBalancedEC 3.3.2.9, 3.3.2.10nucleus
Human-GEM MAR01021CC BY 4.0Reference data