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Proteins/UNIPROT:Q9H0J9
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Acts as an antiviral factor by cooperating with PARP11 to suppress Zika virus replication. Displays anti-alphavirus activity during IFN-gamma immune activation by directly ADP-ribosylating the alphaviral non-structural proteins nsP3 and nsP4. Acts as a component of the PRKD1-driven regulatory cascade that selectively controls a major branch of the basolateral transport pathway by catalyzing the MARylation of GOLGA1. Acts also as a key regulator of mitochondrial function, protein translation, and inflammation. Inhibits PINK1/Parkin-dependent mitophagy and promotes cartilage degeneration by inhibiting the ubiquitination and SUMOylation of MFN1/2 by up-regulating ISG15 and ISGylation..
Function from UniProtKB (Q9H0J9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
46 statements
46 statements · 4 reference databases · Subject: PARP12 · Sources: Bgee, Hetionet, Human-GEM, WikiPathways
3 reactions
6 names
Resolves to: PARP12
Human-GEM MAR09487CC BY 4.0Reference data
L-aspartyl-[protein]+NAD(1-)4-O-(ADP-D-ribosyl)-L-aspartyl-[protein]+nicotinamide
Catalysed by TNKS or PARP1 or PARP6 or PARP15 or PARP10 or TIPARP or PARP16 or PARP12 or TNKS2 or PARP11 or PARP2 or PARP4 and 1 more alternative
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54424CC BY 4.0Reference data
L-cysteinyl-[protein]+NAD(1-)S-(ADP-D-ribosyl)-L-cysteinyl-[protein]+nicotinamide+hydron
Catalysed by PARP6 or TIPARP or PARP8 or PARP12 or PARP11 or SIRT4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:56612CC BY 4.0Reference data