Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q08431

MFGE8

Protein·UNIPROT:Q08431

Open in the graph

Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction..

Continue reading

[Medin]: Main constituent of aortic medial amyloid..

Function from UniProtKB (Q08431), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

23 statements

23 statements · 3 reference databases · Subject: MFGE8 · Sources: Hetionet, Reactome, WikiPathways

Search this listOrder

MFGE8 interacts with PDGFRBProteinHetionet hetionet:interacts:4240-5159Inferred only
MFGE8 interacts with UBCProteinHetionet hetionet:interacts:4240-7316Inferred only
MFGE8 participates in Amyloid fiber formationPathwayReactome R-HSA-977225Inferred only
MFGE8 participates in Complement system in neuronal development and plasticityPathwayWikiPathways WP5090Inferred only
MFGE8 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
MFGE8 participates in Developmental Cell LineagesPathwayReactome R-HSA-9734767Inferred only
MFGE8 participates in Developmental Cell Lineages of the Integumentary SystemPathwayReactome R-HSA-9734779Inferred only
MFGE8 participates in Developmental Lineage of Mammary Gland Alveolar CellsPathwayReactome R-HSA-9927426Inferred only
MFGE8 participates in Developmental Lineages of the Mammary GlandPathwayReactome R-HSA-9924644Inferred only
MFGE8 participates in Ebola virus infection in hostPathwayWikiPathways WP4217Inferred only
MFGE8 participates in Extracellular vesicle mediated signaling in recipient cellsPathwayWikiPathways WP2870Inferred only
MFGE8 participates in Extrafollicular and follicular B cell activation by SARS CoV 2PathwayWikiPathways WP5218Inferred only

Show the remaining 11

MFGE8 participates in Glucocorticoid receptor pathwayPathwayWikiPathways WP2880Inferred only
MFGE8 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
MFGE8 participates in Nuclear receptors meta pathwayPathwayWikiPathways WP2882Inferred only
MFGE8 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
MFGE8 participates in Post-translational protein phosphorylationPathwayReactome R-HSA-8957275Inferred only
MFGE8 participates in Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)PathwayReactome R-HSA-381426Inferred only
AKT1 increases the expression of MFGE8ProteinHetionet hetionet:regulates:207-4240Inferred only
ATP6V0C increases the expression of MFGE8ProteinHetionet hetionet:regulates:527-4240Inferred only
DECR1 increases the expression of MFGE8ProteinHetionet hetionet:regulates:1666-4240Inferred only
HDGFL3 decreases the expression of MFGE8ProteinHetionet hetionet:regulates:50810-4240Inferred only
RAB4A increases the expression of MFGE8ProteinHetionet hetionet:regulates:5867-4240Inferred only

Other names

7 names

Resolves to: MFGE8

Also called: [Cleaved into: Lactadherin short form; Medin]Breast epithelial antigen BA46HMFGMFG-E8MFGMMilk fat globule-EGF factor 8SED1

← Every protein Find it in the graph →