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Proteins/UNIPROT:P42126
Auxiliary enzyme in the beta-oxidation of mono- and polyunsaturated fatty acids. Together with the 2,4-dienoyl-CoA reductase (DECR) and the Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase (ECH1), they allow the reentrance of the enoyl-CoA into the beta-oxidation cycle. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of fatty enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length, and based on its established catalytic mechanism, it is predicted to act also on other fatty acids besides those tested experimentally (By similarity)..
Function from UniProtKB (P42126), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
93 statements
93 statements · 5 reference databases · Subject: ECI1 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
88 reactions
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA+CHEBI:1146900+water+NAD(+)(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA+CHEBI:15351+proton+NADH(2-)
Catalysed by ACADL & HADHA & ECI1 & HADHB & ECH1 & DECR1 or ECI2 & ACADL & HADHA & HADHB &
5 names
Resolves to: ECI1
Reaction pageLeft to rightBalancedEC 4.2.1.74mitochondrial matrix
Human-GEM MAR00970CC BY 4.0Reference data
MAM01119x+waterMAM00689x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR01164CC BY 4.0Reference data
MAM01121x+waterMAM00690x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR01207CC BY 4.0Reference data
MAM00026x+waterMAM00581x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR01256CC BY 4.0Reference data
MAM01037x+waterMAM00691x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR01273CC BY 4.0Reference data
MAM00027x+waterMAM00419x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR01292CC BY 4.0Reference data
MAM00401xMAM00422x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageReversibleBalancedEC 5.3.3.8peroxisome
Human-GEM MAR01298CC BY 4.0Reference data
MAM00401x+waterMAM00397x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR01299CC BY 4.0Reference data
water+MAM03028xMAM00717x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR02409CC BY 4.0Reference data
MAM01664x+waterMAM00801x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR02511CC BY 4.0Reference data
(2E)-hexacosenoyl-CoA+waterMAM00783x
Catalysed by HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR03058CC BY 4.0Reference data
(2E)-tetracosenoyl-CoA+waterMAM00800x
Catalysed by ECI2 & HADHA & ECI1 & EHHADH
Reaction pageLeft to rightBalancedEC 4.2.1.17peroxisome
Human-GEM MAR03063CC BY 4.0Reference data