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Proteins/UNIPROT:O14494
Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes. It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P. Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes. May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (By similarity)..
Function from UniProtKB (O14494), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
354 statements
354 statements · 8 reference databases · Subject: PLPP1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
26 reactions
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
8 names
Resolves to: PLPP1
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00597CC BY 4.0Reference data
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00598CC BY 4.0Reference data
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00599CC BY 4.0Reference data
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00600CC BY 4.0Reference data
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00601CC BY 4.0Reference data
water+phosphatidic acida 1,2-diacyl-sn-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00602CC BY 4.0Reference data
water+sphinganine 1-phosphatephosphate(3-)+CHEBI:16566
Catalysed by PLPP1 or PLPP2 or PLPP3
Reaction pageLeft to rightBalancedEC 3.1.3.4cytosol
Human-GEM MAR00746CC BY 4.0Reference data
MAM01431c+wateran N-acylsphing-4-enine+phosphate(3-)
Catalysed by PLPP1 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.4cytosol
Human-GEM MAR00767CC BY 4.0Reference data
water+sphingosine 1-phosphatephosphate(3-)+sphing-4-enine
Catalysed by PLPP1 or LPIN2 or LPIN3 or PLPP2 or PLPP3 or SGPP2
Reaction pageLeft to rightBalancedEC 3.1.3.4cytosol
Human-GEM MAR00775CC BY 4.0Reference data
water+sphingosine 1-phosphatephosphate(3-)+sphing-4-enine
Catalysed by PLPP1 or PLPP2 or PLPP3
Reaction pageLeft to rightBalancedEC 3.1.3.4extracellular space
Human-GEM MAR00783CC BY 4.0Reference data
2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate+water2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol+phosphate(3-)
Catalysed by PLPP1 or LPIN2 or PLPPR2 or PLPPR4 or PLPPR3 or LPIN3 or LPIN1 or PLPP2 or PLPP5 or PLPP3 or PLPP4
Reaction pageReversibleBalancedEC 3.1.3.4cytosol
Human-GEM MAR01352CC BY 4.0Reference data