Proteins/UNIPROT:P50539

MXI1

ProteinUNIPROT:P50539

Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.

Function from UniProtKB (P50539), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

76 statements

76 statements · 3 reference databases · Subject: MXI1 · Sources: gene ontology, Hetionet, WikiPathways

Order

LRRC10B covaries with MXI1ProteinHetionet hetionet:covaries:390205-4601Inferred only
APP interacts with MXI1ProteinHetionet hetionet:interacts:351-4601Inferred only
MAX interacts with MXI1ProteinHetionet hetionet:interacts:4149-4601Inferred only
MXI1 interacts with MYCProteinHetionet hetionet:interacts:4601-4609Inferred only
MXI1 interacts with SIN3AProteinHetionet hetionet:interacts:25942-4601Inferred only
MXI1 interacts with SIN3BProteinHetionet hetionet:interacts:23309-4601Inferred only
MXI1 interacts with SMC3ProteinHetionet hetionet:interacts:4601-9126Inferred only
MXI1 interacts with UBCProteinHetionet hetionet:interacts:4601-7316Inferred only
MXI1 participates in Hematopoietic stem cell differentiationPathwayWikiPathways WP2849Inferred only
MXI1 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology P50539|GO:0000122Inferred only
MXI1 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology P50539|GO:0006357Inferred only
AK3 increases the expression of MXI1ProteinHetionet hetionet:regulates:50808-4601Inferred only

Show the remaining 64

AKR1B1 increases the expression of MXI1ProteinHetionet hetionet:regulates:231-4601Inferred only
MXI1 decreases the expression of ANO10ProteinHetionet hetionet:regulates:4601-55129Inferred only
ATP6V1D increases the expression of MXI1ProteinHetionet hetionet:regulates:51382-4601Inferred only
ATR increases the expression of MXI1ProteinHetionet hetionet:regulates:545-4601Inferred only
MXI1 decreases the expression of CANT1ProteinHetionet hetionet:regulates:4601-124583Inferred only
MXI1 decreases the expression of CCNB2ProteinHetionet hetionet:regulates:4601-9133Inferred only
MXI1 decreases the expression of CDC20ProteinHetionet hetionet:regulates:4601-991Inferred only
MXI1 decreases the expression of CHMP6ProteinHetionet hetionet:regulates:4601-79643Inferred only
MXI1 decreases the expression of CNDP2ProteinHetionet hetionet:regulates:4601-55748Inferred only
MXI1 increases the expression of COQ8AProteinHetionet hetionet:regulates:4601-56997Inferred only
MXI1 decreases the expression of COTL1ProteinHetionet hetionet:regulates:4601-23406Inferred only
MXI1 increases the expression of CRIP1ProteinHetionet hetionet:regulates:4601-1396Inferred only
MXI1 decreases the expression of CSKProteinHetionet hetionet:regulates:4601-1445Inferred only
DDB2 increases the expression of MXI1ProteinHetionet hetionet:regulates:1643-4601Inferred only
MXI1 decreases the expression of DECR1ProteinHetionet hetionet:regulates:4601-1666Inferred only
MXI1 decreases the expression of DNAJA3ProteinHetionet hetionet:regulates:4601-9093Inferred only
MXI1 decreases the expression of DRAP1ProteinHetionet hetionet:regulates:4601-10589Inferred only
DYNLL1 increases the expression of MXI1ProteinHetionet hetionet:regulates:8655-4601Inferred only
MXI1 decreases the expression of EBNA1BP2ProteinHetionet hetionet:regulates:4601-10969Inferred only
MXI1 decreases the expression of EEF1A2ProteinHetionet hetionet:regulates:4601-1917Inferred only
MXI1 decreases the expression of ETFBProteinHetionet hetionet:regulates:4601-2109Inferred only
MXI1 decreases the expression of FBXO7ProteinHetionet hetionet:regulates:4601-25793Inferred only
FGG increases the expression of MXI1ProteinHetionet hetionet:regulates:2266-4601Inferred only
GATAD1 increases the expression of MXI1ProteinHetionet hetionet:regulates:57798-4601Inferred only
MXI1 decreases the expression of GJA1ProteinHetionet hetionet:regulates:4601-2697Inferred only
GMPS increases the expression of MXI1ProteinHetionet hetionet:regulates:8833-4601Inferred only
MXI1 increases the expression of GRNProteinHetionet hetionet:regulates:4601-2896Inferred only
MXI1 decreases the expression of GSTZ1ProteinHetionet hetionet:regulates:4601-2954Inferred only
MXI1 increases the expression of HPProteinHetionet hetionet:regulates:4601-3240Inferred only
HPD increases the expression of MXI1ProteinHetionet hetionet:regulates:3242-4601Inferred only
JAZF1 increases the expression of MXI1ProteinHetionet hetionet:regulates:221895-4601Inferred only
KNDC1 increases the expression of MXI1ProteinHetionet hetionet:regulates:85442-4601Inferred only
MXI1 decreases the expression of LBRProteinHetionet hetionet:regulates:4601-3930Inferred only
MXI1 increases the expression of NDUFAF4ProteinHetionet hetionet:regulates:4601-29078Inferred only
NME9 increases the expression of MXI1ProteinHetionet hetionet:regulates:347736-4601Inferred only
OTUD7A increases the expression of MXI1ProteinHetionet hetionet:regulates:161725-4601Inferred only
OVOL2 increases the expression of MXI1ProteinHetionet hetionet:regulates:58495-4601Inferred only
PAPOLA increases the expression of MXI1ProteinHetionet hetionet:regulates:10914-4601Inferred only
PPAT increases the expression of MXI1ProteinHetionet hetionet:regulates:5471-4601Inferred only
PPIA increases the expression of MXI1ProteinHetionet hetionet:regulates:5478-4601Inferred only
PROCR increases the expression of MXI1ProteinHetionet hetionet:regulates:10544-4601Inferred only
MXI1 decreases the expression of PRPF4ProteinHetionet hetionet:regulates:4601-9128Inferred only
PSMD3 increases the expression of MXI1ProteinHetionet hetionet:regulates:5709-4601Inferred only
MXI1 decreases the expression of PTPROProteinHetionet hetionet:regulates:4601-5800Inferred only
MXI1 decreases the expression of PXMP2ProteinHetionet hetionet:regulates:4601-5827Inferred only
RAB11A increases the expression of MXI1ProteinHetionet hetionet:regulates:8766-4601Inferred only
RORC increases the expression of MXI1ProteinHetionet hetionet:regulates:6097-4601Inferred only
MXI1 decreases the expression of RPA2ProteinHetionet hetionet:regulates:4601-6118Inferred only
MXI1 decreases the expression of RPIAProteinHetionet hetionet:regulates:4601-22934Inferred only
RUVBL2 increases the expression of MXI1ProteinHetionet hetionet:regulates:10856-4601Inferred only
MXI1 increases the expression of SGCBProteinHetionet hetionet:regulates:4601-6443Inferred only
SLC25A13 decreases the expression of MXI1ProteinHetionet hetionet:regulates:10165-4601Inferred only
MXI1 decreases the expression of SLC7A5ProteinHetionet hetionet:regulates:4601-8140Inferred only
SLC7A9 increases the expression of MXI1ProteinHetionet hetionet:regulates:11136-4601Inferred only
MXI1 increases the expression of SPP1ProteinHetionet hetionet:regulates:4601-6696Inferred only
MXI1 decreases the expression of STUB1ProteinHetionet hetionet:regulates:4601-10273Inferred only
MXI1 decreases the expression of TIMM17BProteinHetionet hetionet:regulates:4601-10245Inferred only
TLR7 increases the expression of MXI1ProteinHetionet hetionet:regulates:51284-4601Inferred only
MXI1 decreases the expression of TOMM34ProteinHetionet hetionet:regulates:4601-10953Inferred only
MXI1 decreases the expression of TYMSProteinHetionet hetionet:regulates:4601-7298Inferred only
MXI1 decreases the expression of USP22ProteinHetionet hetionet:regulates:4601-23326Inferred only
WARS2 increases the expression of MXI1ProteinHetionet hetionet:regulates:10352-4601Inferred only
ZIM3 increases the expression of MXI1ProteinHetionet hetionet:regulates:114026-4601Inferred only
ZNF517 increases the expression of MXI1ProteinHetionet hetionet:regulates:340385-4601Inferred only

Other names

3 names

Resolves to: MXI1

Also called: BHLHC11Class C basic helix-loop-helix protein 11Max interactor 1

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