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Proteins/UNIPROT:Q14392
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity)..
Function from UniProtKB (Q14392), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
92 statements
92 statements · 2 reference databases · Subject: LRRC32 · Sources: gene ontology, Hetionet
5 names
Resolves to: LRRC32