Proteins/UNIPROT:P20592

MX2

ProteinUNIPROT:P20592

Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression..

Function from UniProtKB (P20592), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

26 statements

26 statements · 4 reference databases · Subject: MX2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

MX2 covaries with HACL2ProteinHetionet hetionet:covaries:10994-4600Inferred only
MX2 covaries with STAP2ProteinHetionet hetionet:covaries:4600-55620Inferred only
MX2 interacts with UBCProteinHetionet hetionet:interacts:4600-7316Inferred only
MX2 participates in Antimicrobial mechanism of IFN-stimulated genesPathwayReactome R-HSA-1169410Inferred only
MX2 participates in CAMKK2 pathwayPathwayWikiPathways WP4874Inferred only
MX2 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
MX2 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
MX2 participates in Interferon alpha/beta signalingPathwayReactome R-HSA-909733Inferred only
MX2 participates in Interferon SignalingPathwayReactome R-HSA-913531Inferred only
MX2 participates in ISG15 antiviral mechanismPathwayReactome R-HSA-1169408Inferred only
MX2 participates in Vitamin D receptor pathwayPathwayWikiPathways WP2877Inferred only
MX2 regulates regulation of cell cycleBiological processgene ontology P20592|GO:0051726Inferred only

Show the remaining 14

MX2 regulates regulation of nucleocytoplasmic transportBiological processgene ontology P20592|GO:0046822Inferred only
AFF1 increases the expression of MX2ProteinHetionet hetionet:regulates:4299-4600Inferred only
BCL2L2 increases the expression of MX2ProteinHetionet hetionet:regulates:599-4600Inferred only
BTG1 increases the expression of MX2ProteinHetionet hetionet:regulates:694-4600Inferred only
CBR1 increases the expression of MX2ProteinHetionet hetionet:regulates:873-4600Inferred only
DECR1 increases the expression of MX2ProteinHetionet hetionet:regulates:1666-4600Inferred only
DUSP28 increases the expression of MX2ProteinHetionet hetionet:regulates:285193-4600Inferred only
ELP1 increases the expression of MX2ProteinHetionet hetionet:regulates:8518-4600Inferred only
IFNA10 increases the expression of MX2ProteinHetionet hetionet:regulates:3446-4600Inferred only
IFNB1 increases the expression of MX2ProteinHetionet hetionet:regulates:3456-4600Inferred only
PUF60 increases the expression of MX2ProteinHetionet hetionet:regulates:22827-4600Inferred only
SIRT1 increases the expression of MX2ProteinHetionet hetionet:regulates:23411-4600Inferred only
TNFRSF1A increases the expression of MX2ProteinHetionet hetionet:regulates:7132-4600Inferred only
TXLNA increases the expression of MX2ProteinHetionet hetionet:regulates:200081-4600Inferred only

Other names

3 names

Resolves to: MX2

Also called: Interferon-regulated resistance GTP-binding protein MxBMyxovirus resistance protein 2p78-related protein

← Every protein Find it in the graph →