Proteins/UNIPROT:Q8WYA0

IFT81

ProteinUNIPROT:Q8WYA0

Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling. Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella (By similarity)..

Function from UniProtKB (Q8WYA0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

short-rib thoracic dysplasia 19 with or without polydactyly has a germline basis in IFT81DiseaseGenCC HGNC:14313|MONDO:0033485Inferred only

Statements

28 statements

28 statements · 4 reference databases · Subject: IFT81 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

IFT81 covaries with C12orf71ProteinHetionet hetionet:covaries:28981-728858Inferred only
APP interacts with IFT81ProteinHetionet hetionet:interacts:28981-351Inferred only
UBC interacts with IFT81ProteinHetionet hetionet:interacts:28981-7316Inferred only
IFT81 participates in Alstrom syndromePathwayWikiPathways WP5202Inferred only
IFT81 participates in Assembly of the 9+0 primary ciliumPathwayReactome R-HSA-9975921Inferred only
IFT81 participates in Bardet Biedl syndromePathwayWikiPathways WP5234Inferred only
IFT81 participates in Ciliary landscapePathwayWikiPathways WP4352Inferred only
IFT81 participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
IFT81 participates in Cilium AssemblyPathwayReactome R-HSA-5617833Inferred only
IFT81 participates in Genes related to primary cilium development based on CRISPR PathwayWikiPathways WP4536Inferred only
IFT81 participates in Intraflagellar transportPathwayReactome R-HSA-5620924Inferred only
IFT81 participates in Intraflagellar transport proteins binding to dyneinPathwayWikiPathways WP4532Inferred only

Show the remaining 16

IFT81 participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only
IFT81 participates in Smith Magenis and Potocki Lupski syndrome copy number variationPathwayWikiPathways WP5381Inferred only
IFT81 regulates regulation of smoothened signaling pathwayBiological processgene ontology Q8WYA0|GO:0008589Inferred only
AP2A2 increases the expression of IFT81ProteinHetionet hetionet:regulates:161-28981Inferred only
DECR1 decreases the expression of IFT81ProteinHetionet hetionet:regulates:1666-28981Inferred only
DHCR7 increases the expression of IFT81ProteinHetionet hetionet:regulates:1717-28981Inferred only
FOXJ1 increases the expression of IFT81ProteinHetionet hetionet:regulates:2302-28981Inferred only
FZD5 increases the expression of IFT81ProteinHetionet hetionet:regulates:7855-28981Inferred only
GNAS increases the expression of IFT81ProteinHetionet hetionet:regulates:2778-28981Inferred only
GSTM2 decreases the expression of IFT81ProteinHetionet hetionet:regulates:2946-28981Inferred only
GTF2E2 decreases the expression of IFT81ProteinHetionet hetionet:regulates:2961-28981Inferred only
HRH1 increases the expression of IFT81ProteinHetionet hetionet:regulates:3269-28981Inferred only
HSF1 increases the expression of IFT81ProteinHetionet hetionet:regulates:3297-28981Inferred only
LGR6 increases the expression of IFT81ProteinHetionet hetionet:regulates:59352-28981Inferred only
SMAD4 increases the expression of IFT81ProteinHetionet hetionet:regulates:4089-28981Inferred only
SMARCB1 decreases the expression of IFT81ProteinHetionet hetionet:regulates:6598-28981Inferred only

Other names

3 names

Resolves to: IFT81

Also called: Carnitine deficiency-associated protein expressed in ventricle 1CDV-1CDV1

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