Proteins/UNIPROT:Q13936

CACNA1C

ProteinUNIPROT:Q139361 compound

Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable)..

[Isoform 12]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents..

[Isoform 13]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents..

[Isoform 14]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents..

[Isoform 15]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents..

[Isoform 16]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents..

[Isoform 17]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents..

[Isoform 18]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents..

[Isoform 19]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents..

[Isoform 20]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents..

[Isoform 21]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents..

[Isoform 22]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents..

[Isoform 23]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents..

[Isoform 24]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents..

[Isoform 25]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents..

[Isoform 26]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents..

[Isoform 27]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents..

[Isoform 34]: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents..

(Microbial infection) Acts as a receptor for Influenzavirus. May play a critical role in allowing virus entry when sialylated and expressed on lung tissues..

Function from UniProtKB (Q13936), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · transported by

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

Ca(2+)ElementCHEBI:29108Inferred only18 paths16 endpoints

What the reference databases state

GenCC submitters' classifications

5 rows

Brugada syndrome has a germline basis in CACNA1CDiseaseGenCC HGNC:1390|MONDO:0015263Inferred only
long QT syndrome has a germline basis in CACNA1CDiseaseGenCC HGNC:1390|MONDO:0002442Inferred only
long QT syndrome 8 has a germline basis in CACNA1CDiseaseGenCC HGNC:1390|MONDO:0032756Inferred only
neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures has a germline basis in CACNA1CDiseaseGenCC HGNC:1390|MONDO:0859286Inferred only
Timothy syndrome has a germline basis in CACNA1CDiseaseGenCC HGNC:1390|MONDO:0010979Inferred only

Statements

79 statements

79 statements · 5 reference databases · Subject: CACNA1C · Sources: gene ontology, Hetionet, Reactome, Rhea, WikiPathways

Order

DCUN1D2 covaries with CACNA1CProteinHetionet hetionet:covaries:55208-775Inferred only
GIMAP1-GIMAP5 covaries with CACNA1CProteinHetionet hetionet:covaries:100527949-775Inferred only
SLC6A18 covaries with CACNA1CProteinHetionet hetionet:covaries:348932-775Inferred only
BIN1 interacts with CACNA1CProteinHetionet hetionet:interacts:274-775Inferred only
CACNA1C interacts with CABP1ProteinHetionet hetionet:interacts:775-9478Inferred only
CACNA1C interacts with CACNB1ProteinHetionet hetionet:interacts:775-782Inferred only
CACNA1C interacts with CACNB2ProteinHetionet hetionet:interacts:775-783Inferred only
CACNA1C interacts with CACNB3ProteinHetionet hetionet:interacts:775-784Inferred only
CACNA1C interacts with CALM1ProteinHetionet hetionet:interacts:775-801Inferred only
CACNA1C interacts with CALM1ProteinHetionet hetionet:interacts:775-805Inferred only
CACNA1C interacts with CALM1ProteinHetionet hetionet:interacts:775-808Inferred only
CACNA1C interacts with CAND1ProteinHetionet hetionet:interacts:55832-775Inferred only

Show the remaining 67

CACNA1C interacts with COPS5ProteinHetionet hetionet:interacts:10987-775Inferred only
CACNA1C interacts with CUL1ProteinHetionet hetionet:interacts:775-8454Inferred only
CACNA1C interacts with GNB1ProteinHetionet hetionet:interacts:2782-775Inferred only
CACNA1C interacts with HDAC4ProteinHetionet hetionet:interacts:775-9759Inferred only
CACNA1C interacts with PCBD1ProteinHetionet hetionet:interacts:5092-775Inferred only
CACNA1C interacts with PPM1AProteinHetionet hetionet:interacts:5494-775Inferred only
CACNA1C interacts with PRKACAProteinHetionet hetionet:interacts:5566-775Inferred only
CACNA1C interacts with RIMS1ProteinHetionet hetionet:interacts:22999-775Inferred only
CACNA1C interacts with RYR2ProteinHetionet hetionet:interacts:6262-775Inferred only
CACNA1C interacts with SRIProteinHetionet hetionet:interacts:6717-775Inferred only
CACNA1C participates in Adrenaline,noradrenaline inhibits insulin secretionPathwayReactome R-HSA-400042Inferred only
CACNA1C participates in Alzheimer 39 s diseasePathwayWikiPathways WP5124Inferred only
CACNA1C participates in Alzheimer 39 s disease and miRNA effectsPathwayWikiPathways WP2059Inferred only
CACNA1C participates in Arrhythmogenic right ventricular cardiomyopathyPathwayWikiPathways WP2118Inferred only
CACNA1C participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
CACNA1C participates in Calcium regulation in cardiac cellsPathwayWikiPathways WP536Inferred only
CACNA1C participates in Cardiac conductionPathwayReactome R-HSA-5576891Inferred only
CACNA1C participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
CACNA1C participates in Integration of energy metabolismPathwayReactome R-HSA-163685Inferred only
CACNA1C participates in MAPK signalingPathwayWikiPathways WP382Inferred only
CACNA1C participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
CACNA1C participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only
CACNA1C participates in NCAM signaling for neurite out-growthPathwayReactome R-HSA-375165Inferred only
CACNA1C participates in NCAM1 interactionsPathwayReactome R-HSA-419037Inferred only
CACNA1C participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
CACNA1C participates in Nicotine effect on chromaffin cellsPathwayWikiPathways WP1603Inferred only
CACNA1C participates in Phase 0 - rapid depolarisationPathwayReactome R-HSA-5576892Inferred only
CACNA1C participates in Phase 2 - plateau phasePathwayReactome R-HSA-5576893Inferred only
CACNA1C participates in Regulation of insulin secretionPathwayReactome R-HSA-422356Inferred only
CACNA1C participates in Synaptic signaling associated with autism spectrum disorderPathwayWikiPathways WP4539Inferred only
CACNA1C participates in Vitamin D sensitive calcium signaling in depressionPathwayWikiPathways WP4698Inferred only
CACNA1C regulates positive regulation of adenylate cyclase activityBiological processgene ontology Q13936|GO:0045762Inferred only
CACNA1C regulates positive regulation of cytosolic calcium ion concentrationBiological processgene ontology Q13936|GO:0007204Inferred only
CACNA1C regulates positive regulation of muscle contractionBiological processgene ontology Q13936|GO:0045933Inferred only
CACNA1C regulates regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionBiological processgene ontology Q13936|GO:0010881Inferred only
CACNA1C regulates regulation of heart rate by cardiac conductionBiological processgene ontology Q13936|GO:0086091Inferred only
CACNA1C regulates regulation of ventricular cardiac muscle cell action potentialBiological processgene ontology Q13936|GO:0098911Inferred only
CACNA1C decreases the expression of ACO2ProteinHetionet hetionet:regulates:775-50Inferred only
CACNA1C decreases the expression of ARFIP2ProteinHetionet hetionet:regulates:775-23647Inferred only
CACNA1C increases the expression of BZW2ProteinHetionet hetionet:regulates:775-28969Inferred only
CACNA1C increases the expression of C2CD2ProteinHetionet hetionet:regulates:775-25966Inferred only
CACNA1C decreases the expression of DECR1ProteinHetionet hetionet:regulates:775-1666Inferred only
CACNA1C decreases the expression of DNAJA3ProteinHetionet hetionet:regulates:775-9093Inferred only
CACNA1C decreases the expression of ENOPH1ProteinHetionet hetionet:regulates:775-58478Inferred only
CACNA1C increases the expression of FASProteinHetionet hetionet:regulates:775-355Inferred only
CACNA1C decreases the expression of GDF15ProteinHetionet hetionet:regulates:775-9518Inferred only
CACNA1C decreases the expression of GJA1ProteinHetionet hetionet:regulates:775-2697Inferred only
CACNA1C decreases the expression of GTF2A2ProteinHetionet hetionet:regulates:775-2958Inferred only
CACNA1C increases the expression of HMGA2ProteinHetionet hetionet:regulates:775-8091Inferred only
CACNA1C decreases the expression of HTATSF1ProteinHetionet hetionet:regulates:775-27336Inferred only
CACNA1C decreases the expression of IARS2ProteinHetionet hetionet:regulates:775-55699Inferred only
CACNA1C increases the expression of JADE2ProteinHetionet hetionet:regulates:775-23338Inferred only
CACNA1C decreases the expression of JPT2ProteinHetionet hetionet:regulates:775-90861Inferred only
CACNA1C decreases the expression of MAPK8IP3ProteinHetionet hetionet:regulates:775-23162Inferred only
CACNA1C decreases the expression of MBOAT7ProteinHetionet hetionet:regulates:775-79143Inferred only
CACNA1C decreases the expression of PMM1ProteinHetionet hetionet:regulates:775-5372Inferred only
CACNA1C decreases the expression of PPP2R5AProteinHetionet hetionet:regulates:775-5525Inferred only
CACNA1C decreases the expression of RNF167ProteinHetionet hetionet:regulates:775-26001Inferred only
CACNA1C increases the expression of SATB1ProteinHetionet hetionet:regulates:775-6304Inferred only
CACNA1C increases the expression of SERPINA3ProteinHetionet hetionet:regulates:775-12Inferred only
CACNA1C decreases the expression of SLC25A4ProteinHetionet hetionet:regulates:775-291Inferred only
CACNA1C decreases the expression of SLC7A5ProteinHetionet hetionet:regulates:775-8140Inferred only
CACNA1C decreases the expression of SPON2ProteinHetionet hetionet:regulates:775-10417Inferred only
CACNA1C increases the expression of TGFBR2ProteinHetionet hetionet:regulates:775-7048Inferred only
CACNA1C increases the expression of TRAM2ProteinHetionet hetionet:regulates:775-9697Inferred only
CACNA1C decreases the expression of TXNDC9ProteinHetionet hetionet:regulates:775-10190Inferred only
Ca(2+) is transported by CACNA1CCompoundRhea RHEA:29671Inferred only

Reactions

1 reaction

Ca(2+)Ca(2+)
Transported by ANO9 or HTR3E or TMEM150C or CACNA1A or GRIN2D or P2RX6 or GRID2 or CACNA1G or GRIN3B or CACNA1F or TRPA1 or TRPM2 and 106 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29671CC BY 4.0Reference data

Other names

6 names

Resolves to: CACNA1C

Also called: CACH2CACN2CACNL1A1Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscleCCHL1A1Voltage-gated calcium channel subunit alpha Cav1.2

← Every protein Find it in the graph →