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Proteins/UNIPROT:O15297
Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity)..
Function from UniProtKB (O15297), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
117 statements
117 statements · 5 reference databases · Subject: PPM1D · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways
2 reactions
7 names
Resolves to: PPM1D
O-phospho-L-threonyl-[protein]+waterL-threonyl-[protein]+hydrogenphosphate
Catalysed by PPP6C or CTDSP2 or PPEF1 or PPEF2 or CTDSPL or PPM1D or PPM1G or PHLPP1 or CDC14B or PPM1B or DUSP14 or EPM2A and 59 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47004CC BY 4.0Reference data