glycodeoxycholate

Two steps

• 5-aminolevulinic acidReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by ALAS1, ALAS2, CPNE7cytosol, mitochondrial matrix

• L-cysteineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of cysteine and glycine (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A5, SLC7A8cytosol, extracellular spaceOne of 4 routes

• urateReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)

  Catalysed by ABCC4, SLC22A13inner side of the membrane, outer side of the membrane

• methylarsonous acidReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by ABCC4, GSTO1, GSTO2inner side of the membrane, outer side of the membrane

• CHEBI:17895Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of glycine and tyrosine (cytosol to extracellular)

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 4 routes

• CHEBI:18019Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of glycine and lysine (cytosol to extracellular)

  Catalysed by SLC7A6cytosol, extracellular spaceOne of 2 routes

• L-glutamineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of glutamine and glycine (cytosol to extracellular)

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 4 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by GARTcytosol

• arsenic triglutathioneReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by ABCC4, AS3MTinner side of the membrane, outer side of the membraneOne of 3 routes

• ophthalmateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by GSScytosol

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by ABCC4, MGST3inner side of the membrane, outer side of the membrane

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by ABCC4, GPX1, GPX4inner side of the membrane, outer side of the membrane

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by ABCC4, GPX1, GPX4inner side of the membrane, outer side of the membrane

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by ABCC4, GPX1, GPX4inner side of the membrane, outer side of the membrane

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by ABCC4, GPX1, GPX4inner side of the membrane, outer side of the membrane

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by ABCC4, GPX4inner side of the membrane, outer side of the membrane

• deoxycholate 3-sulfateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. deoxycholate + 3'-phosphoadenylyl sulfate = deoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SULT2A1cytosol

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by AGXT2cytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by SHMT1cytosolOne of 2 routes

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by ABCC4, GSTP1inner side of the membrane, outer side of the membrane

• CHEBI:240943Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrix

• a quinolReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by ABCC4, SQORinner side of the membrane, outer side of the membrane

• phenylacetylglycineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by GLYATcytosolOne of 3 routes

• CHEBI:28666Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. LTD4 hydrolysis

  No catalyst recordedcytosol

• L-ascorbic acidReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by ABCC4, CLIC1, GSTO1, GSTO2inner side of the membrane, outer side of the membrane

• Gly-tRNA(Gly)Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by GARS1cytosol

• chlorine(.)Reach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of chloride and glycine (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14cytosol, extracellular spaceOne of 3 routes

• glycocholateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by BAATcytosol, peroxisomeOne of 4 routes

• cholateReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by ABCC4inner side of the membrane, outer side of the membrane

• hydrogen sulfideReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by ABCC4, TSTD1inner side of the membrane, outer side of the membrane

• an alcoholReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by ABCC4, CP, PRDX6inner side of the membrane, outer side of the membrane

• 5-aminolevulinateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by ALAS1, ALAS2cytosol

• glycochenodeoxycholateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by BAATcytosolOne of 2 routes

• taurocholateReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. taurocholate(in) + glutathione(in) + ATP + H2O = taurocholate(out) + glutathione(out) + ADP + phosphate + H(+)

  Catalysed by ABCC4inner side of the membrane, outer side of the membrane

• glycochenodeoxycholic acidReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by BAATcytosol, peroxisomeOne of 3 routes

• glyoxylateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by AADATcytosolOne of 11 routes

• glycolithocholic acidReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by BAATcytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by GCATcytosol, mitochondrial matrix

• tert-butanolReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by ABCC4, CLIC2, GPX1, GPX2 and 2 moreinner side of the membrane, outer side of the membrane

• L-ornithineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. L-Arginine:glycine amidinotransferase

  Catalysed by GATMcytosolOne of 5 routes

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by GLDC, GCSHcytosol, mitochondrial matrix

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by ABCC4, GPX1, GPX2, GPX4inner side of the membrane, outer side of the membrane

• sarcosineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by PIPOXcytosolOne of 2 routes

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by SHMT1, SHMT2cytosol

• (R)-S-lactoylglutathioneReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. (R)-S-lactoylglutathione = methylglyoxal + glutathione

  Catalysed by ABCC4, GLO1inner side of the membrane, outer side of the membrane

• an N-acylglycineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by GLYATL3, GLYAT, GLYATL2cytosol

• S-formylglutathioneReach from here →
  1. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  2. S-formylglutathione + H2O = formate + glutathione + H(+)

  Catalysed by ABCC4, ESDinner side of the membrane, outer side of the membrane

• guanidinoacetateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. L-Arginine:glycine amidinotransferase

  Catalysed by GATMcytosolOne of 2 routes

• L-methionineReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of glycine and methionine (cytosol to extracellular)

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 5 routes

• L-tryptophanReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. transport of glycine and tryptophan (cytosol to extracellular)

  Catalysed by SLC7A5cytosol, extracellular spaceOne of 5 routes